Development of Pseudomembranous Colitis Four Months after Initiation of Rifampicin
Pseudomembranous colitis (PMC) may develop with long-term antibiotic administration, but is rarely reported to be caused by antitubercular agents. We present a case of PMC that occurred 120 days after starting rifampicin. A 74-year-old man was diagnosed with pulmonary tuberculosis and started on a s...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2011-01-01
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| Series: | Case Reports in Gastroenterology |
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| Online Access: | http://www.karger.com/Article/FullText/323753 |
| _version_ | 1811307413268070400 |
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| author | Jeong Moon Choi Hyung Hun Kim Seun Ja Park Moo In Park Won Moon |
| author_facet | Jeong Moon Choi Hyung Hun Kim Seun Ja Park Moo In Park Won Moon |
| author_sort | Jeong Moon Choi |
| collection | DOAJ |
| description | Pseudomembranous colitis (PMC) may develop with long-term antibiotic administration, but is rarely reported to be caused by antitubercular agents. We present a case of PMC that occurred 120 days after starting rifampicin. A 74-year-old man was diagnosed with pulmonary tuberculosis and started on a standard HERZ regimen (isoniazid, ethambutol, rifampicin, pyrazinamide). After 4 months of HERZ, he presented with frequent bloody, mucoid, jelly-like diarrhea and lower abdominal pain. Sigmoidoscopy revealed multiple whitish plaques with edematous mucosa that were compatible with PMC. Biopsies from these lesions showed ulcer-related necrotic and granulation tissue. We stopped antitubercular treatment and started the patient on oral metronidazole. His symptoms completely resolved within 2 weeks. Antitubercular treatment was restarted by replacing rifampicin with levofloxacin. The patient did not present with diarrhea or bloody stool throughout the rest of treatment. |
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| format | Article |
| id | doaj.art-fc1b0f1cfe584d57a27e19e10be8d898 |
| institution | Directory Open Access Journal |
| issn | 1662-0631 |
| language | English |
| last_indexed | 2024-04-13T09:03:55Z |
| publishDate | 2011-01-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Gastroenterology |
| spelling | doaj.art-fc1b0f1cfe584d57a27e19e10be8d8982022-12-22T02:53:03ZengKarger PublishersCase Reports in Gastroenterology1662-06312011-01-0151455110.1159/000323753323753Development of Pseudomembranous Colitis Four Months after Initiation of RifampicinJeong Moon ChoiHyung Hun KimSeun Ja ParkMoo In ParkWon MoonPseudomembranous colitis (PMC) may develop with long-term antibiotic administration, but is rarely reported to be caused by antitubercular agents. We present a case of PMC that occurred 120 days after starting rifampicin. A 74-year-old man was diagnosed with pulmonary tuberculosis and started on a standard HERZ regimen (isoniazid, ethambutol, rifampicin, pyrazinamide). After 4 months of HERZ, he presented with frequent bloody, mucoid, jelly-like diarrhea and lower abdominal pain. Sigmoidoscopy revealed multiple whitish plaques with edematous mucosa that were compatible with PMC. Biopsies from these lesions showed ulcer-related necrotic and granulation tissue. We stopped antitubercular treatment and started the patient on oral metronidazole. His symptoms completely resolved within 2 weeks. Antitubercular treatment was restarted by replacing rifampicin with levofloxacin. The patient did not present with diarrhea or bloody stool throughout the rest of treatment.http://www.karger.com/Article/FullText/323753Pseudomembranous colitisRifampicinTuberculosis |
| spellingShingle | Jeong Moon Choi Hyung Hun Kim Seun Ja Park Moo In Park Won Moon Development of Pseudomembranous Colitis Four Months after Initiation of Rifampicin Case Reports in Gastroenterology Pseudomembranous colitis Rifampicin Tuberculosis |
| title | Development of Pseudomembranous Colitis Four Months after Initiation of Rifampicin |
| title_full | Development of Pseudomembranous Colitis Four Months after Initiation of Rifampicin |
| title_fullStr | Development of Pseudomembranous Colitis Four Months after Initiation of Rifampicin |
| title_full_unstemmed | Development of Pseudomembranous Colitis Four Months after Initiation of Rifampicin |
| title_short | Development of Pseudomembranous Colitis Four Months after Initiation of Rifampicin |
| title_sort | development of pseudomembranous colitis four months after initiation of rifampicin |
| topic | Pseudomembranous colitis Rifampicin Tuberculosis |
| url | http://www.karger.com/Article/FullText/323753 |
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