Efferocytosis and Its Role in Inflammatory Disorders
Efferocytosis is the effective clearance of apoptotic cells by professional and non-professional phagocytes. The process is mechanically different from other forms of phagocytosis and involves the localization, binding, internalization, and degradation of apoptotic cells. Defective efferocytosis has...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.839248/full |
| _version_ | 1818323086559150080 |
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| author | Yun Ge Man Huang Yong-ming Yao Yong-ming Yao |
| author_facet | Yun Ge Man Huang Yong-ming Yao Yong-ming Yao |
| author_sort | Yun Ge |
| collection | DOAJ |
| description | Efferocytosis is the effective clearance of apoptotic cells by professional and non-professional phagocytes. The process is mechanically different from other forms of phagocytosis and involves the localization, binding, internalization, and degradation of apoptotic cells. Defective efferocytosis has been demonstrated to associate with the pathogenesis of various inflammatory disorders. In the current review, we summarize recent findings with regard to efferocytosis networks and discuss the relationship between efferocytosis and different immune cell populations, as well as describe how efferocytosis helps resolve inflammatory response and modulate immune balance. Our knowledge so far about efferocytosis suggests that it may be a useful target in the treatment of numerous inflammatory diseases. |
| first_indexed | 2024-12-13T11:07:06Z |
| format | Article |
| id | doaj.art-fc1b28942b1b43dd88ca1954911793e8 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-13T11:07:06Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-fc1b28942b1b43dd88ca1954911793e82022-12-21T23:48:57ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-02-011010.3389/fcell.2022.839248839248Efferocytosis and Its Role in Inflammatory DisordersYun Ge0Man Huang1Yong-ming Yao2Yong-ming Yao3Department of General Intensive Care Unit, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of General Intensive Care Unit, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of General Intensive Care Unit, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaTranslational Medicine Research Center, Medical Innovation Research Division and Fourth Medical Center of the Chinese PLA General Hospital, Beijing, ChinaEfferocytosis is the effective clearance of apoptotic cells by professional and non-professional phagocytes. The process is mechanically different from other forms of phagocytosis and involves the localization, binding, internalization, and degradation of apoptotic cells. Defective efferocytosis has been demonstrated to associate with the pathogenesis of various inflammatory disorders. In the current review, we summarize recent findings with regard to efferocytosis networks and discuss the relationship between efferocytosis and different immune cell populations, as well as describe how efferocytosis helps resolve inflammatory response and modulate immune balance. Our knowledge so far about efferocytosis suggests that it may be a useful target in the treatment of numerous inflammatory diseases.https://www.frontiersin.org/articles/10.3389/fcell.2022.839248/fullapoptosisefferocytosisinflammatory diseasesimmune responsephagocytosis |
| spellingShingle | Yun Ge Man Huang Yong-ming Yao Yong-ming Yao Efferocytosis and Its Role in Inflammatory Disorders Frontiers in Cell and Developmental Biology apoptosis efferocytosis inflammatory diseases immune response phagocytosis |
| title | Efferocytosis and Its Role in Inflammatory Disorders |
| title_full | Efferocytosis and Its Role in Inflammatory Disorders |
| title_fullStr | Efferocytosis and Its Role in Inflammatory Disorders |
| title_full_unstemmed | Efferocytosis and Its Role in Inflammatory Disorders |
| title_short | Efferocytosis and Its Role in Inflammatory Disorders |
| title_sort | efferocytosis and its role in inflammatory disorders |
| topic | apoptosis efferocytosis inflammatory diseases immune response phagocytosis |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.839248/full |
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