Ischemia Enhances the Acute Stretch-Induced Increase in Calcium Spark Rate in Ventricular Myocytes

Ischemia Enhances the Acute Stretch-Induced Increase in Calcium Spark Rate in Ventricular Myocytes

Introduction: In ventricular myocytes, spontaneous release of calcium (Ca2+) from the sarcoplasmic reticulum via ryanodine receptors (“Ca2+ sparks”) is acutely increased by stretch, due to a stretch-induced increase of reactive oxygen species (ROS). In acute regional ischemia there is stretch of isc...

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Bibliographic Details
Main Authors: Breanne A. Cameron, Hiroaki Kai, Keiko Kaihara, Gentaro Iribe, T. Alexander Quinn
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Physiology
Subjects:
calcium
ischemia
myocytes
reactive oxygen species
stretch
ventricle
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00289/full

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