Effects of trimethylamine N-oxide and urea on DNA duplex and G-quadruplex

Effects of trimethylamine N-oxide and urea on DNA duplex and G-quadruplex

We systematically investigated effects of molecular crowding with trimethylamine N-oxide (TMAO) as a zwitterionic and protective osmolyte and urea as a nonionic denaturing osmolyte on conformation and thermodynamics of the canonical DNA duplex and the non-canonical DNA G-quadruplex. It was found tha...

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Bibliographic Details
Main Authors: Yu-mi Ueda, Yu-ki Zouzumi, Atsushi Maruyama, Shu-ichi Nakano, Naoki Sugimoto, Daisuke Miyoshi
Format: Article
Language:English
Published: Taylor & Francis Group 2016-01-01
Series:Science and Technology of Advanced Materials
Subjects:
dna
g-quadruplex
duplex
molecular crowding
osomolyte
Online Access:http://dx.doi.org/10.1080/14686996.2016.1243000

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