The Impact of Endometrioma on Embryo Quality in In Vitro Fertilization: A Retrospective Cohort Study
The influence of endometrioma on oocyte and embryo competence is inconclusive. Furthermore, the benefits of surgical treatment remain uncertain. This study aimed to investigate the effect of endometrioma on oocyte and embryo quality from a morphological perspective and further explore whether surger...
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| Format: | Article |
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MDPI AG
2023-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/6/2416 |
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| author | Houjin Dongye Yizheng Tian Dan Qi Yanbo Du Lei Yan |
| author_facet | Houjin Dongye Yizheng Tian Dan Qi Yanbo Du Lei Yan |
| author_sort | Houjin Dongye |
| collection | DOAJ |
| description | The influence of endometrioma on oocyte and embryo competence is inconclusive. Furthermore, the benefits of surgical treatment remain uncertain. This study aimed to investigate the effect of endometrioma on oocyte and embryo quality from a morphological perspective and further explore whether surgery could contribute to improving oocyte and embryo competence. A total of 664 IVF cycles with endometrioma (538 cycles underwent surgeries) and 3133 IVF cycles from the control group were included. The propensity score matching was used to balance the baseline differences between groups. There was a lower MII oocyte rate (85.0% versus 87.8%, <i>p</i> < 0.001; 84.9% versus 87.6%, <i>p</i> = 0.001) and a similar good-quality embryos rate in women with endometrioma (and those who underwent surgeries) compared with control group. For women with endometrioma, the rates of blastocyst development (67.1% versus 60.2%; <i>p</i> = 0.013) and good blastocyst development (40.7% versus 35.2%; <i>p</i> = 0.049) were significantly higher in those who had undergone surgical treatment compared with those who had not, but the rates of MII oocytes (79.9% versus 87.7%; <i>p</i> < 0.001) and normal fertilization (55.2% versus 66.2%; <i>p</i> < 0.001) were lower. The study indicates that endometrioma, including its surgical treatment, compromises the oocyte maturity not the embryo quality at the cleavage stage; however, the surgery seems to contribute to improving blastocyst development. |
| first_indexed | 2024-03-11T06:22:40Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T06:22:40Z |
| publishDate | 2023-03-01 |
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| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-fc1f46cbd13944a5900d01a179fcade82023-11-17T11:52:34ZengMDPI AGJournal of Clinical Medicine2077-03832023-03-01126241610.3390/jcm12062416The Impact of Endometrioma on Embryo Quality in In Vitro Fertilization: A Retrospective Cohort StudyHoujin Dongye0Yizheng Tian1Dan Qi2Yanbo Du3Lei Yan4Center for Reproductive Medicine, Shandong University, Jinan 250012, ChinaCenter for Reproductive Medicine, Shandong University, Jinan 250012, ChinaCenter for Reproductive Medicine, Shandong University, Jinan 250012, ChinaCenter for Reproductive Medicine, Shandong University, Jinan 250012, ChinaCenter for Reproductive Medicine, Shandong University, Jinan 250012, ChinaThe influence of endometrioma on oocyte and embryo competence is inconclusive. Furthermore, the benefits of surgical treatment remain uncertain. This study aimed to investigate the effect of endometrioma on oocyte and embryo quality from a morphological perspective and further explore whether surgery could contribute to improving oocyte and embryo competence. A total of 664 IVF cycles with endometrioma (538 cycles underwent surgeries) and 3133 IVF cycles from the control group were included. The propensity score matching was used to balance the baseline differences between groups. There was a lower MII oocyte rate (85.0% versus 87.8%, <i>p</i> < 0.001; 84.9% versus 87.6%, <i>p</i> = 0.001) and a similar good-quality embryos rate in women with endometrioma (and those who underwent surgeries) compared with control group. For women with endometrioma, the rates of blastocyst development (67.1% versus 60.2%; <i>p</i> = 0.013) and good blastocyst development (40.7% versus 35.2%; <i>p</i> = 0.049) were significantly higher in those who had undergone surgical treatment compared with those who had not, but the rates of MII oocytes (79.9% versus 87.7%; <i>p</i> < 0.001) and normal fertilization (55.2% versus 66.2%; <i>p</i> < 0.001) were lower. The study indicates that endometrioma, including its surgical treatment, compromises the oocyte maturity not the embryo quality at the cleavage stage; however, the surgery seems to contribute to improving blastocyst development.https://www.mdpi.com/2077-0383/12/6/2416endometriomaoocyte qualityembryo qualityIVF |
| spellingShingle | Houjin Dongye Yizheng Tian Dan Qi Yanbo Du Lei Yan The Impact of Endometrioma on Embryo Quality in In Vitro Fertilization: A Retrospective Cohort Study Journal of Clinical Medicine endometrioma oocyte quality embryo quality IVF |
| title | The Impact of Endometrioma on Embryo Quality in In Vitro Fertilization: A Retrospective Cohort Study |
| title_full | The Impact of Endometrioma on Embryo Quality in In Vitro Fertilization: A Retrospective Cohort Study |
| title_fullStr | The Impact of Endometrioma on Embryo Quality in In Vitro Fertilization: A Retrospective Cohort Study |
| title_full_unstemmed | The Impact of Endometrioma on Embryo Quality in In Vitro Fertilization: A Retrospective Cohort Study |
| title_short | The Impact of Endometrioma on Embryo Quality in In Vitro Fertilization: A Retrospective Cohort Study |
| title_sort | impact of endometrioma on embryo quality in in vitro fertilization a retrospective cohort study |
| topic | endometrioma oocyte quality embryo quality IVF |
| url | https://www.mdpi.com/2077-0383/12/6/2416 |
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