Serum chemerin levels are independently associated with quality of life in colorectal cancer survivors: A pilot study.
Colorectal cancer (CRC) survivors are known to experience various symptoms that significantly affect their quality of life (QOL); therefore, it is important to identify clinical markers related with CRC survivor QOL. Here we investigated the relationship between serum chemerin levels, a newly identi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5419570?pdf=render |
| _version_ | 1819113608180662272 |
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| author | Jee-Yon Lee Mi-Kyung Lee Nam-Kyu Kim Sang-Hui Chu Duk-Chul Lee Hye-Sun Lee Ji-Won Lee Justin Y Jeon |
| author_facet | Jee-Yon Lee Mi-Kyung Lee Nam-Kyu Kim Sang-Hui Chu Duk-Chul Lee Hye-Sun Lee Ji-Won Lee Justin Y Jeon |
| author_sort | Jee-Yon Lee |
| collection | DOAJ |
| description | Colorectal cancer (CRC) survivors are known to experience various symptoms that significantly affect their quality of life (QOL); therefore, it is important to identify clinical markers related with CRC survivor QOL. Here we investigated the relationship between serum chemerin levels, a newly identified proinflammatory adipokine, and QOL in CRC survivors.A data of total of 110 CRC survivors were analysed in the study. Serum chemerin levels were measured with an enzyme immunoassay analyser. Functional Assessment of Cancer Therapy (FACT) scores were used as an indicator of QOL in CRC survivors.Weak but not negligible relationships were observed between serum chemerin levels and FACT-General (G) (r = -0.22, p<0.02), FACT-Colorectal cancer (C) (r = -0.23, p<0.02) and FACT-Fatigue (F) scores (r = -0.27, p<0.01) after adjusting for confounding factors. Both stepwise and enter method multiple linear regression analyses confirmed that serum chemerin levels were independently associated with FACT-G (stepwise: β = -0.15, p<0.01; enter: β = -0.12, p = 0.02), FACT-C (stepwise: β = -0.19, p<0.01; enter; β = -0.14, p = 0.02) and FACT-F scores (stepwise: β = -0.23, p<0.01; enter: β = -0.20, p<0.01).Our results demonstrate a weak inverse relationship between serum chemerin and CRC survivor QOL. Although it is impossible to determine causality, our findings suggest that serum chemerin levels may have a significant association with CRC survivor QOL. Further prospective studies are required to confirm the clinical significance of our pilot study. |
| first_indexed | 2024-12-22T04:32:06Z |
| format | Article |
| id | doaj.art-fc1f8c2058524a5289981fd6f3d84b20 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T04:32:06Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-fc1f8c2058524a5289981fd6f3d84b202022-12-21T18:39:01ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01125e017692910.1371/journal.pone.0176929Serum chemerin levels are independently associated with quality of life in colorectal cancer survivors: A pilot study.Jee-Yon LeeMi-Kyung LeeNam-Kyu KimSang-Hui ChuDuk-Chul LeeHye-Sun LeeJi-Won LeeJustin Y JeonColorectal cancer (CRC) survivors are known to experience various symptoms that significantly affect their quality of life (QOL); therefore, it is important to identify clinical markers related with CRC survivor QOL. Here we investigated the relationship between serum chemerin levels, a newly identified proinflammatory adipokine, and QOL in CRC survivors.A data of total of 110 CRC survivors were analysed in the study. Serum chemerin levels were measured with an enzyme immunoassay analyser. Functional Assessment of Cancer Therapy (FACT) scores were used as an indicator of QOL in CRC survivors.Weak but not negligible relationships were observed between serum chemerin levels and FACT-General (G) (r = -0.22, p<0.02), FACT-Colorectal cancer (C) (r = -0.23, p<0.02) and FACT-Fatigue (F) scores (r = -0.27, p<0.01) after adjusting for confounding factors. Both stepwise and enter method multiple linear regression analyses confirmed that serum chemerin levels were independently associated with FACT-G (stepwise: β = -0.15, p<0.01; enter: β = -0.12, p = 0.02), FACT-C (stepwise: β = -0.19, p<0.01; enter; β = -0.14, p = 0.02) and FACT-F scores (stepwise: β = -0.23, p<0.01; enter: β = -0.20, p<0.01).Our results demonstrate a weak inverse relationship between serum chemerin and CRC survivor QOL. Although it is impossible to determine causality, our findings suggest that serum chemerin levels may have a significant association with CRC survivor QOL. Further prospective studies are required to confirm the clinical significance of our pilot study.http://europepmc.org/articles/PMC5419570?pdf=render |
| spellingShingle | Jee-Yon Lee Mi-Kyung Lee Nam-Kyu Kim Sang-Hui Chu Duk-Chul Lee Hye-Sun Lee Ji-Won Lee Justin Y Jeon Serum chemerin levels are independently associated with quality of life in colorectal cancer survivors: A pilot study. PLoS ONE |
| title | Serum chemerin levels are independently associated with quality of life in colorectal cancer survivors: A pilot study. |
| title_full | Serum chemerin levels are independently associated with quality of life in colorectal cancer survivors: A pilot study. |
| title_fullStr | Serum chemerin levels are independently associated with quality of life in colorectal cancer survivors: A pilot study. |
| title_full_unstemmed | Serum chemerin levels are independently associated with quality of life in colorectal cancer survivors: A pilot study. |
| title_short | Serum chemerin levels are independently associated with quality of life in colorectal cancer survivors: A pilot study. |
| title_sort | serum chemerin levels are independently associated with quality of life in colorectal cancer survivors a pilot study |
| url | http://europepmc.org/articles/PMC5419570?pdf=render |
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