Prognostic Value of Genes and Immune Infiltration in Prostate Tumor Microenvironment
BackgroundProstate cancer (PCa) is one of the most common cancers and the fifth leading cause of cancer-related death in men. Immune responses in the tumor microenvironment are hypothesized to be related to the prognosis of PCa patients; however, no studies are available to confirm the same. In this...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.584055/full |
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| author | Wenguo Sun Hailin Shi Zhen Yuan Li Xia Xuebao Xiang Xiangfeng Quan Wenjie Shi Leiming Jiang |
| author_facet | Wenguo Sun Hailin Shi Zhen Yuan Li Xia Xuebao Xiang Xiangfeng Quan Wenjie Shi Leiming Jiang |
| author_sort | Wenguo Sun |
| collection | DOAJ |
| description | BackgroundProstate cancer (PCa) is one of the most common cancers and the fifth leading cause of cancer-related death in men. Immune responses in the tumor microenvironment are hypothesized to be related to the prognosis of PCa patients; however, no studies are available to confirm the same. In this study, we aimed to explore the potential link between these two factors and identify new biomarkers to estimate the survival rate of PCa patients.MethodsA total of 490 cases were obtained from The Cancer Genome Atlas (TCGA) database. The gene expression data were analyzed by the ESTIMATE algorithm to evaluate the immune and stromal scores. The survival rate was calculated according to the case-specific clinical data. Enrichment analysis was performed to discover the main biological processes and signaling pathways of immune responses. We further identified and analyzed hub genes in the protein-protein interaction (PPI) network and evaluated their prognostic values.ResultsImmune score significantly correlated with immune cell infiltration and overall survival of PCa patients. The genes CXCR4 and GPR183, identified as hub genes in the PPI network, correlated with immune cell infiltration and prognosis of PCa patients.ConclusionCXCR4 and GPR183 participate in immune cell infiltration and function in PCa patients. The immune score, as well as the expression of CXCR4 and GPR183 in prostate cancer tissues, could be potential indexes for the prognosis of prostate cancer. |
| first_indexed | 2024-12-21T11:23:28Z |
| format | Article |
| id | doaj.art-fc204f1be4b84a67a199d5f78d045282 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-21T11:23:28Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-fc204f1be4b84a67a199d5f78d0452822022-12-21T19:05:43ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-10-011010.3389/fonc.2020.584055584055Prognostic Value of Genes and Immune Infiltration in Prostate Tumor MicroenvironmentWenguo Sun0Hailin Shi1Zhen Yuan2Li Xia3Xuebao Xiang4Xiangfeng Quan5Wenjie Shi6Leiming Jiang7Department of Urology, Affiliated Hospital of Guilin Medical University, Guilin, ChinaDepartment of Urology, Affiliated Hospital of Guilin Medical University, Guilin, ChinaDepartment of Urology, Fuyang People’s Hospital, Fuyang, ChinaDepartment of Dermatology, Guilin People’s Hospital, Guilin, ChinaDepartment of Urology, Affiliated Hospital of Guilin Medical University, Guilin, ChinaDepartment of Urology, Affiliated Hospital of Guilin Medical University, Guilin, ChinaDepartment of Gynecology, Pius Hospital of Oldenburg, Oldenburg, GermanyDepartment of Urology, Affiliated Hospital of Guilin Medical University, Guilin, ChinaBackgroundProstate cancer (PCa) is one of the most common cancers and the fifth leading cause of cancer-related death in men. Immune responses in the tumor microenvironment are hypothesized to be related to the prognosis of PCa patients; however, no studies are available to confirm the same. In this study, we aimed to explore the potential link between these two factors and identify new biomarkers to estimate the survival rate of PCa patients.MethodsA total of 490 cases were obtained from The Cancer Genome Atlas (TCGA) database. The gene expression data were analyzed by the ESTIMATE algorithm to evaluate the immune and stromal scores. The survival rate was calculated according to the case-specific clinical data. Enrichment analysis was performed to discover the main biological processes and signaling pathways of immune responses. We further identified and analyzed hub genes in the protein-protein interaction (PPI) network and evaluated their prognostic values.ResultsImmune score significantly correlated with immune cell infiltration and overall survival of PCa patients. The genes CXCR4 and GPR183, identified as hub genes in the PPI network, correlated with immune cell infiltration and prognosis of PCa patients.ConclusionCXCR4 and GPR183 participate in immune cell infiltration and function in PCa patients. The immune score, as well as the expression of CXCR4 and GPR183 in prostate cancer tissues, could be potential indexes for the prognosis of prostate cancer.https://www.frontiersin.org/articles/10.3389/fonc.2020.584055/fullprostate tumorprognostic genesimmune infiltratetumor microenvironmentCXCR4GPR183 |
| spellingShingle | Wenguo Sun Hailin Shi Zhen Yuan Li Xia Xuebao Xiang Xiangfeng Quan Wenjie Shi Leiming Jiang Prognostic Value of Genes and Immune Infiltration in Prostate Tumor Microenvironment Frontiers in Oncology prostate tumor prognostic genes immune infiltrate tumor microenvironment CXCR4 GPR183 |
| title | Prognostic Value of Genes and Immune Infiltration in Prostate Tumor Microenvironment |
| title_full | Prognostic Value of Genes and Immune Infiltration in Prostate Tumor Microenvironment |
| title_fullStr | Prognostic Value of Genes and Immune Infiltration in Prostate Tumor Microenvironment |
| title_full_unstemmed | Prognostic Value of Genes and Immune Infiltration in Prostate Tumor Microenvironment |
| title_short | Prognostic Value of Genes and Immune Infiltration in Prostate Tumor Microenvironment |
| title_sort | prognostic value of genes and immune infiltration in prostate tumor microenvironment |
| topic | prostate tumor prognostic genes immune infiltrate tumor microenvironment CXCR4 GPR183 |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2020.584055/full |
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