A New Photoactivatable Ruthenium(II) Complex with an Asymmetric Bis-Thiocarbohydrazone: Chemical and Biological Investigations
The synthesis, photoactivation and biological activity of a new piano-stool Ru(II) complex is herein reported. The peculiarity of this complex is that its monodentate ligand which undergoes the photodissociation is an asymmetric bis-thiocarbohydrazone ligand that possesses a pyridine moiety binding...
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| Format: | Article |
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MDPI AG
2021-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/4/939 |
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| author | Marianna Pioli Nicolò Orsoni Mirco Scaccaglia Rossella Alinovi Silvana Pinelli Giorgio Pelosi Franco Bisceglie |
| author_facet | Marianna Pioli Nicolò Orsoni Mirco Scaccaglia Rossella Alinovi Silvana Pinelli Giorgio Pelosi Franco Bisceglie |
| author_sort | Marianna Pioli |
| collection | DOAJ |
| description | The synthesis, photoactivation and biological activity of a new piano-stool Ru(II) complex is herein reported. The peculiarity of this complex is that its monodentate ligand which undergoes the photodissociation is an asymmetric bis-thiocarbohydrazone ligand that possesses a pyridine moiety binding to Ru(II) and the other moiety contains a quinoline that endows the ligand with the capacity of chelating other metal ions. In this way, upon dissociation, the ligand can be released in the form of a metal complex. In this article, the double ability of this new Ru(II) complex to photorelease the ligand and to chelate copper and nickel is explored and confirmed. The biological activity of this compound is studied in cell line A549 revealing that, after irradiation, proliferation inhibition is reached at very low half maximal inhibitory concentration (IC<sub>50</sub>) values. Further, biological assays reveal that the dinuclear complex containing Ni is internalized in cells. |
| first_indexed | 2024-03-09T04:49:25Z |
| format | Article |
| id | doaj.art-fc20d3c2e0ae41f1a8617e82e663d9e4 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T04:49:25Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-fc20d3c2e0ae41f1a8617e82e663d9e42023-12-03T13:12:11ZengMDPI AGMolecules1420-30492021-02-0126493910.3390/molecules26040939A New Photoactivatable Ruthenium(II) Complex with an Asymmetric Bis-Thiocarbohydrazone: Chemical and Biological InvestigationsMarianna Pioli0Nicolò Orsoni1Mirco Scaccaglia2Rossella Alinovi3Silvana Pinelli4Giorgio Pelosi5Franco Bisceglie6Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, ItalyDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, ItalyDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, ItalyDepartment of Medicine and Surgery, University of Parma, 43126 Parma, ItalyDepartment of Medicine and Surgery, University of Parma, 43126 Parma, ItalyDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, ItalyDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, ItalyThe synthesis, photoactivation and biological activity of a new piano-stool Ru(II) complex is herein reported. The peculiarity of this complex is that its monodentate ligand which undergoes the photodissociation is an asymmetric bis-thiocarbohydrazone ligand that possesses a pyridine moiety binding to Ru(II) and the other moiety contains a quinoline that endows the ligand with the capacity of chelating other metal ions. In this way, upon dissociation, the ligand can be released in the form of a metal complex. In this article, the double ability of this new Ru(II) complex to photorelease the ligand and to chelate copper and nickel is explored and confirmed. The biological activity of this compound is studied in cell line A549 revealing that, after irradiation, proliferation inhibition is reached at very low half maximal inhibitory concentration (IC<sub>50</sub>) values. Further, biological assays reveal that the dinuclear complex containing Ni is internalized in cells.https://www.mdpi.com/1420-3049/26/4/939thiocarbohydrazoneRu(II) complexphotoactivationanticancer activityasymmetric complexes |
| spellingShingle | Marianna Pioli Nicolò Orsoni Mirco Scaccaglia Rossella Alinovi Silvana Pinelli Giorgio Pelosi Franco Bisceglie A New Photoactivatable Ruthenium(II) Complex with an Asymmetric Bis-Thiocarbohydrazone: Chemical and Biological Investigations Molecules thiocarbohydrazone Ru(II) complex photoactivation anticancer activity asymmetric complexes |
| title | A New Photoactivatable Ruthenium(II) Complex with an Asymmetric Bis-Thiocarbohydrazone: Chemical and Biological Investigations |
| title_full | A New Photoactivatable Ruthenium(II) Complex with an Asymmetric Bis-Thiocarbohydrazone: Chemical and Biological Investigations |
| title_fullStr | A New Photoactivatable Ruthenium(II) Complex with an Asymmetric Bis-Thiocarbohydrazone: Chemical and Biological Investigations |
| title_full_unstemmed | A New Photoactivatable Ruthenium(II) Complex with an Asymmetric Bis-Thiocarbohydrazone: Chemical and Biological Investigations |
| title_short | A New Photoactivatable Ruthenium(II) Complex with an Asymmetric Bis-Thiocarbohydrazone: Chemical and Biological Investigations |
| title_sort | new photoactivatable ruthenium ii complex with an asymmetric bis thiocarbohydrazone chemical and biological investigations |
| topic | thiocarbohydrazone Ru(II) complex photoactivation anticancer activity asymmetric complexes |
| url | https://www.mdpi.com/1420-3049/26/4/939 |
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