MRI-guided intracerebral convection-enhanced injection of gliotoxins to induce focal demyelination in swine.

MRI-guided intracerebral convection-enhanced injection of gliotoxins to induce focal demyelination in swine.

Demyelinating disorders such as multiple sclerosis (MS) or transverse myelitis are devastating neurological conditions with no effective cure. Prevention of myelin loss or restoration of myelin are key for successful therapy. To investigate the disease and develop cures animal models with good clini...

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Main Authors: Lukasz Kalkowski, Izabela Malysz-Cymborska, Dominika Golubczyk, Miroslaw Janowski, Piotr Holak, Kamila Milewska, Dorota Kedziorek, Zbigniew Adamiak, Wojciech Maksymowicz, Piotr Walczak
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6166947?pdf=render

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