Enhancing Pullulan Soft Capsules with a Mixture of Glycerol and Sorbitol Plasticizers: A Multi-Dimensional Study
The plasticizer is crucial in the plant-based soft capsule. However, meeting the quality requirements of these capsules with a single plasticizer is challenging. To address this issue, this study first investigated the impact of a plasticizer mixture containing sorbitol and glycerol in varying mass...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/15/10/2247 |
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| author | Kecheng Zhou Yucheng Yang Bingde Zheng Qiqi Yu Yayan Huang Na Zhang Shriram Mourougane Rama Xueqin Zhang Jing Ye Meitian Xiao |
| author_facet | Kecheng Zhou Yucheng Yang Bingde Zheng Qiqi Yu Yayan Huang Na Zhang Shriram Mourougane Rama Xueqin Zhang Jing Ye Meitian Xiao |
| author_sort | Kecheng Zhou |
| collection | DOAJ |
| description | The plasticizer is crucial in the plant-based soft capsule. However, meeting the quality requirements of these capsules with a single plasticizer is challenging. To address this issue, this study first investigated the impact of a plasticizer mixture containing sorbitol and glycerol in varying mass ratios and the performance of the pullulan soft film and capsule. The multiscale analysis demonstrates that the plasticizer mixture exhibits superior effectiveness in enhancing the performance of the pullulan film/capsule compared to a single plasticizer. Furthermore, thermogravimetric analysis, Fourier transform infrared spectroscopy, X-ray diffraction, and scanning electron microscopy indicate that the plasticizer mixture enhances the compatibility and thermal stability of the pullulan films without altering their chemical composition. Among the different mass ratios examined, a 15:15 ratio of sorbitol to glycerol (S/G) is identified as the most optimal, leading to superior physicochemical properties and meeting the requirements for brittleness and disintegration time set by the Chinese Pharmacopoeia. This study provides significant insights into the effect of the plasticizer mixture on the performance of pullulan soft capsules and offers a promising application formula for future use. |
| first_indexed | 2024-03-11T03:23:58Z |
| format | Article |
| id | doaj.art-fc22759a4307423c99aab41ebfc94c5f |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-11T03:23:58Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-fc22759a4307423c99aab41ebfc94c5f2023-11-18T02:57:20ZengMDPI AGPolymers2073-43602023-05-011510224710.3390/polym15102247Enhancing Pullulan Soft Capsules with a Mixture of Glycerol and Sorbitol Plasticizers: A Multi-Dimensional StudyKecheng Zhou0Yucheng Yang1Bingde Zheng2Qiqi Yu3Yayan Huang4Na Zhang5Shriram Mourougane Rama6Xueqin Zhang7Jing Ye8Meitian Xiao9College of Chemical Engineering, Huaqiao University, Xiamen 361021, ChinaCollege of Chemical Engineering, Huaqiao University, Xiamen 361021, ChinaCollege of Chemical Engineering, Huaqiao University, Xiamen 361021, ChinaCollege of Chemical Engineering, Huaqiao University, Xiamen 361021, ChinaCollege of Chemical Engineering, Huaqiao University, Xiamen 361021, ChinaCollege of Chemical Engineering, Huaqiao University, Xiamen 361021, ChinaDepartment of Chemical Engineering and Chemistry, Eindhoven University of Technology, Het Kranenveld (Bldg 14-Helix), 5600 MB Eindhoven, The NetherlandsCollege of Chemical Engineering, Huaqiao University, Xiamen 361021, ChinaCollege of Chemical Engineering, Huaqiao University, Xiamen 361021, ChinaCollege of Chemical Engineering, Huaqiao University, Xiamen 361021, ChinaThe plasticizer is crucial in the plant-based soft capsule. However, meeting the quality requirements of these capsules with a single plasticizer is challenging. To address this issue, this study first investigated the impact of a plasticizer mixture containing sorbitol and glycerol in varying mass ratios and the performance of the pullulan soft film and capsule. The multiscale analysis demonstrates that the plasticizer mixture exhibits superior effectiveness in enhancing the performance of the pullulan film/capsule compared to a single plasticizer. Furthermore, thermogravimetric analysis, Fourier transform infrared spectroscopy, X-ray diffraction, and scanning electron microscopy indicate that the plasticizer mixture enhances the compatibility and thermal stability of the pullulan films without altering their chemical composition. Among the different mass ratios examined, a 15:15 ratio of sorbitol to glycerol (S/G) is identified as the most optimal, leading to superior physicochemical properties and meeting the requirements for brittleness and disintegration time set by the Chinese Pharmacopoeia. This study provides significant insights into the effect of the plasticizer mixture on the performance of pullulan soft capsules and offers a promising application formula for future use.https://www.mdpi.com/2073-4360/15/10/2247soft capsuleplant polysaccharideplasticizer mixtureglycerolsorbitol |
| spellingShingle | Kecheng Zhou Yucheng Yang Bingde Zheng Qiqi Yu Yayan Huang Na Zhang Shriram Mourougane Rama Xueqin Zhang Jing Ye Meitian Xiao Enhancing Pullulan Soft Capsules with a Mixture of Glycerol and Sorbitol Plasticizers: A Multi-Dimensional Study Polymers soft capsule plant polysaccharide plasticizer mixture glycerol sorbitol |
| title | Enhancing Pullulan Soft Capsules with a Mixture of Glycerol and Sorbitol Plasticizers: A Multi-Dimensional Study |
| title_full | Enhancing Pullulan Soft Capsules with a Mixture of Glycerol and Sorbitol Plasticizers: A Multi-Dimensional Study |
| title_fullStr | Enhancing Pullulan Soft Capsules with a Mixture of Glycerol and Sorbitol Plasticizers: A Multi-Dimensional Study |
| title_full_unstemmed | Enhancing Pullulan Soft Capsules with a Mixture of Glycerol and Sorbitol Plasticizers: A Multi-Dimensional Study |
| title_short | Enhancing Pullulan Soft Capsules with a Mixture of Glycerol and Sorbitol Plasticizers: A Multi-Dimensional Study |
| title_sort | enhancing pullulan soft capsules with a mixture of glycerol and sorbitol plasticizers a multi dimensional study |
| topic | soft capsule plant polysaccharide plasticizer mixture glycerol sorbitol |
| url | https://www.mdpi.com/2073-4360/15/10/2247 |
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