The aging of ER-mitochondria communication: A journey from undifferentiated to aged cells
The complex physiology of eukaryotic cells requires that a variety of subcellular organelles perform unique tasks, even though they form highly dynamic communication networks. In the case of the endoplasmic reticulum (ER) and mitochondria, their functional coupling relies on the physical interaction...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.946678/full |
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| author | Pablo Morgado-Cáceres Pablo Morgado-Cáceres Pablo Morgado-Cáceres Gianella Liabeuf Gianella Liabeuf Gianella Liabeuf Ximena Calle Ximena Calle Lautaro Briones Lautaro Briones Lautaro Briones Jaime A. Riquelme Jaime A. Riquelme Roberto Bravo-Sagua Roberto Bravo-Sagua Roberto Bravo-Sagua Valentina Parra Valentina Parra Valentina Parra |
| author_facet | Pablo Morgado-Cáceres Pablo Morgado-Cáceres Pablo Morgado-Cáceres Gianella Liabeuf Gianella Liabeuf Gianella Liabeuf Ximena Calle Ximena Calle Lautaro Briones Lautaro Briones Lautaro Briones Jaime A. Riquelme Jaime A. Riquelme Roberto Bravo-Sagua Roberto Bravo-Sagua Roberto Bravo-Sagua Valentina Parra Valentina Parra Valentina Parra |
| author_sort | Pablo Morgado-Cáceres |
| collection | DOAJ |
| description | The complex physiology of eukaryotic cells requires that a variety of subcellular organelles perform unique tasks, even though they form highly dynamic communication networks. In the case of the endoplasmic reticulum (ER) and mitochondria, their functional coupling relies on the physical interaction between their membranes, mediated by domains known as mitochondria-ER contacts (MERCs). MERCs act as shuttles for calcium and lipid transfer between organelles, and for the nucleation of other subcellular processes. Of note, mounting evidence shows that they are heterogeneous structures, which display divergent behaviors depending on the cell type. Furthermore, MERCs are plastic structures that remodel according to intra- and extracellular cues, thereby adjusting the function of both organelles to the cellular needs. In consonance with this notion, the malfunction of MERCs reportedly contributes to the development of several age-related disorders. Here, we integrate current literature to describe how MERCs change, starting from undifferentiated cells, and their transit through specialization, malignant transformation (i.e., dedifferentiation), and aging/senescence. Along this journey, we will review the function of MERCs and their relevance for pivotal cell types, such as stem and cancer cells, cardiac, skeletal, and smooth myocytes, neurons, leukocytes, and hepatocytes, which intervene in the progression of chronic diseases related to age. |
| first_indexed | 2024-04-11T22:34:26Z |
| format | Article |
| id | doaj.art-fc237bd88628485b9e00adb58a1f4c26 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-11T22:34:26Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-fc237bd88628485b9e00adb58a1f4c262022-12-22T03:59:16ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-08-011010.3389/fcell.2022.946678946678The aging of ER-mitochondria communication: A journey from undifferentiated to aged cellsPablo Morgado-Cáceres0Pablo Morgado-Cáceres1Pablo Morgado-Cáceres2Gianella Liabeuf3Gianella Liabeuf4Gianella Liabeuf5Ximena Calle6Ximena Calle7Lautaro Briones8Lautaro Briones9Lautaro Briones10Jaime A. Riquelme11Jaime A. Riquelme12Roberto Bravo-Sagua13Roberto Bravo-Sagua14Roberto Bravo-Sagua15Valentina Parra16Valentina Parra17Valentina Parra18Advanced Center of Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas e Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile, Santiago, ChileDepartamento de Bioquímica y Biología Molecular y Departamento de Química Farmacológica y Toxicológica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, ChileCenter for Integrative Biology, Faculty of Sciences, Universidad Mayor, Santiago, ChileAdvanced Center of Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas e Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile, Santiago, ChileLaboratorio de Obesidad y Metabolismo Energético (OMEGA), Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile, Santiago, ChileFacultad de Salud y Ciencias Sociales, Escuela de Nutrición y Dietética, Universidad de las Américas, Santiago, ChileAdvanced Center of Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas e Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile, Santiago, ChileDepartamento de Bioquímica y Biología Molecular y Departamento de Química Farmacológica y Toxicológica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, ChileAdvanced Center of Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas e Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile, Santiago, ChileLaboratorio de Obesidad y Metabolismo Energético (OMEGA), Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile, Santiago, ChileDepartamento de Nutrición y Salud Pública, Facultad de Ciencias de la Salud y de los Alimentos, Universidad del Bío-Bío, Chillán, ChileAdvanced Center of Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas e Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile, Santiago, ChileDepartamento de Bioquímica y Biología Molecular y Departamento de Química Farmacológica y Toxicológica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, ChileAdvanced Center of Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas e Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile, Santiago, ChileLaboratorio de Obesidad y Metabolismo Energético (OMEGA), Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile, Santiago, ChileRed de Investigación en Envejecimiento Saludable, Consorcio de Universidades del Estado de Chile, Santiago, ChileAdvanced Center of Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas e Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile, Santiago, ChileDepartamento de Bioquímica y Biología Molecular y Departamento de Química Farmacológica y Toxicológica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, ChileRed para el Estudio de Enfermedades Cardiopulmonares de alta letalidad (REECPAL), Universidad de Chile, Santiago, ChileThe complex physiology of eukaryotic cells requires that a variety of subcellular organelles perform unique tasks, even though they form highly dynamic communication networks. In the case of the endoplasmic reticulum (ER) and mitochondria, their functional coupling relies on the physical interaction between their membranes, mediated by domains known as mitochondria-ER contacts (MERCs). MERCs act as shuttles for calcium and lipid transfer between organelles, and for the nucleation of other subcellular processes. Of note, mounting evidence shows that they are heterogeneous structures, which display divergent behaviors depending on the cell type. Furthermore, MERCs are plastic structures that remodel according to intra- and extracellular cues, thereby adjusting the function of both organelles to the cellular needs. In consonance with this notion, the malfunction of MERCs reportedly contributes to the development of several age-related disorders. Here, we integrate current literature to describe how MERCs change, starting from undifferentiated cells, and their transit through specialization, malignant transformation (i.e., dedifferentiation), and aging/senescence. Along this journey, we will review the function of MERCs and their relevance for pivotal cell types, such as stem and cancer cells, cardiac, skeletal, and smooth myocytes, neurons, leukocytes, and hepatocytes, which intervene in the progression of chronic diseases related to age.https://www.frontiersin.org/articles/10.3389/fcell.2022.946678/fullendoplasmic reticulummitochondriaagingcellular diffentiationchronic diseases |
| spellingShingle | Pablo Morgado-Cáceres Pablo Morgado-Cáceres Pablo Morgado-Cáceres Gianella Liabeuf Gianella Liabeuf Gianella Liabeuf Ximena Calle Ximena Calle Lautaro Briones Lautaro Briones Lautaro Briones Jaime A. Riquelme Jaime A. Riquelme Roberto Bravo-Sagua Roberto Bravo-Sagua Roberto Bravo-Sagua Valentina Parra Valentina Parra Valentina Parra The aging of ER-mitochondria communication: A journey from undifferentiated to aged cells Frontiers in Cell and Developmental Biology endoplasmic reticulum mitochondria aging cellular diffentiation chronic diseases |
| title | The aging of ER-mitochondria communication: A journey from undifferentiated to aged cells |
| title_full | The aging of ER-mitochondria communication: A journey from undifferentiated to aged cells |
| title_fullStr | The aging of ER-mitochondria communication: A journey from undifferentiated to aged cells |
| title_full_unstemmed | The aging of ER-mitochondria communication: A journey from undifferentiated to aged cells |
| title_short | The aging of ER-mitochondria communication: A journey from undifferentiated to aged cells |
| title_sort | aging of er mitochondria communication a journey from undifferentiated to aged cells |
| topic | endoplasmic reticulum mitochondria aging cellular diffentiation chronic diseases |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.946678/full |
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