High Prevalence of Antibiotic-Resistant Otitis Media–Associated Bacterial Flora of Asymptomatic People Living with HIV at Morogoro Hospital, Tanzania
Objectives: The study aimed to determine the prevalence of otitis media (OM)-associated bacterial flora of asymptomatic people living with HIV (PLH) on antiretroviral therapy (ART) and assess antibiotic resistance profiles of the bacteria. Methodology: Ear secretion specimens were collected by syrin...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2018-03-01
|
| Series: | Journal of the International Association of Providers of AIDS Care |
| Online Access: | https://doi.org/10.1177/2325958218759761 |
| _version_ | 1818240159623151616 |
|---|---|
| author | Kennedy Daniel Mwambete MSc Pharm, PhD Mathias Eulambius BPharm, MPharm |
| author_facet | Kennedy Daniel Mwambete MSc Pharm, PhD Mathias Eulambius BPharm, MPharm |
| author_sort | Kennedy Daniel Mwambete MSc Pharm, PhD |
| collection | DOAJ |
| description | Objectives: The study aimed to determine the prevalence of otitis media (OM)-associated bacterial flora of asymptomatic people living with HIV (PLH) on antiretroviral therapy (ART) and assess antibiotic resistance profiles of the bacteria. Methodology: Ear secretion specimens were collected by syringe or cotton swabs. Isolated bacteria were subjected to antibiotic sensitivity tests. Results: Of 290 recruited PLH, 81.7% were females and 18.3% males; their CD4 + counts ranged from 0 to 1770. Staphylococcus aureus , Klebsiella pneumonia , and Escherichia coli were the predominant bacteria. High antibiotic resistance was detected on Streptococcus pyogenes and Streptococcus pneumoniae . The prevalence rate of OM-associated bacteria (OAB) was 93.4%, and majority of the bacteria were resistant to multiple antibiotics. Linear association between the prevalence of OAB with both duration of ART and CD4 + counts was observed. Conclusion: High prevalence rates of OAB and antibiotic resistance were observed. Negative correlation between CD4 + counts and prevalence of OAB was revealed. |
| first_indexed | 2024-12-12T13:09:01Z |
| format | Article |
| id | doaj.art-fc23ca2e12fe4f92b8f4845b19163e19 |
| institution | Directory Open Access Journal |
| issn | 2325-9582 |
| language | English |
| last_indexed | 2024-12-12T13:09:01Z |
| publishDate | 2018-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of the International Association of Providers of AIDS Care |
| spelling | doaj.art-fc23ca2e12fe4f92b8f4845b19163e192022-12-22T00:23:34ZengSAGE PublishingJournal of the International Association of Providers of AIDS Care2325-95822018-03-011710.1177/2325958218759761High Prevalence of Antibiotic-Resistant Otitis Media–Associated Bacterial Flora of Asymptomatic People Living with HIV at Morogoro Hospital, TanzaniaKennedy Daniel Mwambete MSc Pharm, PhD0Mathias Eulambius BPharm, MPharm1 Department of Pharmaceutical Microbiology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, United Republic of Tanzania Department of Pharmaceutics, Muhimbili University of Health and Allied Sciences, Dar es Salaam, United Republic of TanzaniaObjectives: The study aimed to determine the prevalence of otitis media (OM)-associated bacterial flora of asymptomatic people living with HIV (PLH) on antiretroviral therapy (ART) and assess antibiotic resistance profiles of the bacteria. Methodology: Ear secretion specimens were collected by syringe or cotton swabs. Isolated bacteria were subjected to antibiotic sensitivity tests. Results: Of 290 recruited PLH, 81.7% were females and 18.3% males; their CD4 + counts ranged from 0 to 1770. Staphylococcus aureus , Klebsiella pneumonia , and Escherichia coli were the predominant bacteria. High antibiotic resistance was detected on Streptococcus pyogenes and Streptococcus pneumoniae . The prevalence rate of OM-associated bacteria (OAB) was 93.4%, and majority of the bacteria were resistant to multiple antibiotics. Linear association between the prevalence of OAB with both duration of ART and CD4 + counts was observed. Conclusion: High prevalence rates of OAB and antibiotic resistance were observed. Negative correlation between CD4 + counts and prevalence of OAB was revealed.https://doi.org/10.1177/2325958218759761 |
| spellingShingle | Kennedy Daniel Mwambete MSc Pharm, PhD Mathias Eulambius BPharm, MPharm High Prevalence of Antibiotic-Resistant Otitis Media–Associated Bacterial Flora of Asymptomatic People Living with HIV at Morogoro Hospital, Tanzania Journal of the International Association of Providers of AIDS Care |
| title | High Prevalence of Antibiotic-Resistant Otitis Media–Associated Bacterial Flora of Asymptomatic People Living with HIV at Morogoro Hospital, Tanzania |
| title_full | High Prevalence of Antibiotic-Resistant Otitis Media–Associated Bacterial Flora of Asymptomatic People Living with HIV at Morogoro Hospital, Tanzania |
| title_fullStr | High Prevalence of Antibiotic-Resistant Otitis Media–Associated Bacterial Flora of Asymptomatic People Living with HIV at Morogoro Hospital, Tanzania |
| title_full_unstemmed | High Prevalence of Antibiotic-Resistant Otitis Media–Associated Bacterial Flora of Asymptomatic People Living with HIV at Morogoro Hospital, Tanzania |
| title_short | High Prevalence of Antibiotic-Resistant Otitis Media–Associated Bacterial Flora of Asymptomatic People Living with HIV at Morogoro Hospital, Tanzania |
| title_sort | high prevalence of antibiotic resistant otitis media associated bacterial flora of asymptomatic people living with hiv at morogoro hospital tanzania |
| url | https://doi.org/10.1177/2325958218759761 |
| work_keys_str_mv | AT kennedydanielmwambetemscpharmphd highprevalenceofantibioticresistantotitismediaassociatedbacterialfloraofasymptomaticpeoplelivingwithhivatmorogorohospitaltanzania AT mathiaseulambiusbpharmmpharm highprevalenceofantibioticresistantotitismediaassociatedbacterialfloraofasymptomaticpeoplelivingwithhivatmorogorohospitaltanzania |