DRESS syndrome induced by anticonvulsants and fulminant hepatic failure

The drug rash with eosinophilia and systemic symptoms syndrome (DRESS) is a severe hypersensitive reaction induced by the use of medications. More than 100 drugs associated with this syndrome have been reported and, although most patients have a favorable clinical course, about 10% develop multiple...

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Main Authors: Hector Fabio Londoño-Arcila, María Alejandra Guerra-Pabón, Cristhian David Hernández-Revelo, Diego Fernando Hoyos-Samboní, Katherine Vanessa Jiménez-Orrego
Format: Article
Language:English
Published: Universidad Nacional de Colombia 2017-01-01
Series:Revista de la Facultad de Medicina
Subjects:
Online Access:https://revistas.unal.edu.co/index.php/revfacmed/article/view/51919
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author Hector Fabio Londoño-Arcila
María Alejandra Guerra-Pabón
Cristhian David Hernández-Revelo
Diego Fernando Hoyos-Samboní
Katherine Vanessa Jiménez-Orrego
author_facet Hector Fabio Londoño-Arcila
María Alejandra Guerra-Pabón
Cristhian David Hernández-Revelo
Diego Fernando Hoyos-Samboní
Katherine Vanessa Jiménez-Orrego
author_sort Hector Fabio Londoño-Arcila
collection DOAJ
description The drug rash with eosinophilia and systemic symptoms syndrome (DRESS) is a severe hypersensitive reaction induced by the use of medications. More than 100 drugs associated with this syndrome have been reported and, although most patients have a favorable clinical course, about 10% develop multiple organ failure; some cases may result in the death of the patient. This paper presents a clinical case of DRESS syndrome associated with anticonvulsive therapy that evolved to fulminant hepatic failure. The etiology, pathogenesis, clinical manifestations, diagnostic process and possible treatment of this condition are addressed.
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spelling doaj.art-fc2515fc423b41ffb3e29c38ec25147a2022-12-22T03:19:06ZengUniversidad Nacional de ColombiaRevista de la Facultad de Medicina0120-00112357-38482017-01-0165116516810.15446/revfacmed.v65n1.5191945770DRESS syndrome induced by anticonvulsants and fulminant hepatic failureHector Fabio Londoño-Arcila0María Alejandra Guerra-Pabón1Cristhian David Hernández-Revelo2Diego Fernando Hoyos-Samboní3Katherine Vanessa Jiménez-Orrego4Hospital Universitario San José - Unidad de Cuidados Intensivos - Popayán - Colombia.Universidad del Cauca - Facultad de Ciencias de la Salud - Departamento Medicina Interna - Popayán - Colombia.Universidad del Cauca - Facultad de Ciencias de la Salud - Departamento Medicina Interna - Popayán - Colombia.Universidad del Cauca - Facultad de Ciencias de la Salud - Departamento Medicina Interna - Popayán - Colombia.Universidad del Cauca - Facultad de Ciencias de la Salud - Departamento Medicina Interna - Popayán - Colombia.The drug rash with eosinophilia and systemic symptoms syndrome (DRESS) is a severe hypersensitive reaction induced by the use of medications. More than 100 drugs associated with this syndrome have been reported and, although most patients have a favorable clinical course, about 10% develop multiple organ failure; some cases may result in the death of the patient. This paper presents a clinical case of DRESS syndrome associated with anticonvulsive therapy that evolved to fulminant hepatic failure. The etiology, pathogenesis, clinical manifestations, diagnostic process and possible treatment of this condition are addressed.https://revistas.unal.edu.co/index.php/revfacmed/article/view/51919AnticonvulsivantesSíndrome de hipersensibilidad a medicamentosÁcido valproicoFenitoínaFallo hepático
spellingShingle Hector Fabio Londoño-Arcila
María Alejandra Guerra-Pabón
Cristhian David Hernández-Revelo
Diego Fernando Hoyos-Samboní
Katherine Vanessa Jiménez-Orrego
DRESS syndrome induced by anticonvulsants and fulminant hepatic failure
Revista de la Facultad de Medicina
Anticonvulsivantes
Síndrome de hipersensibilidad a medicamentos
Ácido valproico
Fenitoína
Fallo hepático
title DRESS syndrome induced by anticonvulsants and fulminant hepatic failure
title_full DRESS syndrome induced by anticonvulsants and fulminant hepatic failure
title_fullStr DRESS syndrome induced by anticonvulsants and fulminant hepatic failure
title_full_unstemmed DRESS syndrome induced by anticonvulsants and fulminant hepatic failure
title_short DRESS syndrome induced by anticonvulsants and fulminant hepatic failure
title_sort dress syndrome induced by anticonvulsants and fulminant hepatic failure
topic Anticonvulsivantes
Síndrome de hipersensibilidad a medicamentos
Ácido valproico
Fenitoína
Fallo hepático
url https://revistas.unal.edu.co/index.php/revfacmed/article/view/51919
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