Human Mast Cells From Adipose Tissue Target and Induce Apoptosis of Breast Cancer Cells

Human Mast Cells From Adipose Tissue Target and Induce Apoptosis of Breast Cancer Cells

Mast cells (MC) are important immune sentinels found in most tissue and widely recognized for their role as mediators of Type I hypersensitivity. However, they also secrete anti-cancer mediators such as tumor necrosis factor alpha (TNF-α) and granulocyte-macrophage colony-stimulating factor (GM-CSF)...

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Bibliographic Details
Main Authors: Jesse D. Plotkin, Michael G. Elias, Mohammad Fereydouni, Tracy R. Daniels-Wells, Anthony L. Dellinger, Manuel L. Penichet, Christopher L. Kepley
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
mast cells
IgE
cancer
immunotherapy
breast cancer
HER2/neu
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00138/full

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