Mu-opioid receptor selective superagonists produce prolonged respiratory depression

Mu-opioid receptor selective superagonists produce prolonged respiratory depression

Summary: Synthetic opioids are increasingly challenging to combat the opioid epidemic and act primarily at opioid receptors, chiefly the G protein-coupled receptor (GPCR) μ-opioid receptor (MOR), which signals through G protein-dependent and β-arrestin pathways. Using a bioluminescence resonance ene...

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Bibliographic Details
Main Authors: Nicholas J. Malcolm, Barbara Palkovic, Daniel J. Sprague, Maggie M. Calkins, Janelle K. Lanham, Adam L. Halberstadt, Astrid G. Stucke, John D. McCorvy
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:iScience
Subjects:
Cellular neuroscience
Molecular neuroscience
Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223011987

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