Association of Exposure to Abuse, Nurture, and Household Organization in Childhood With 4 Cardiovascular Disease Risks Factors Among Participants in the CARDIA Study
Background We investigated associations of childhood abuse with 4 cardiovascular disease risk factors in adulthood, and whether exposure to nurturing and household organization in childhood mitigated these associations. Methods and Results The CARDIA (Coronary Artery Risk Development in Young Adults...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-05-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.121.023244 |
| _version_ | 1811267042093826048 |
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| author | Liliana Aguayo Diana A. Chirinos Nia Heard‐Garris Mandy Wong Matthew M. Davis Sharon Stein Merkin Teresa Seeman Kiarri N. Kershaw |
| author_facet | Liliana Aguayo Diana A. Chirinos Nia Heard‐Garris Mandy Wong Matthew M. Davis Sharon Stein Merkin Teresa Seeman Kiarri N. Kershaw |
| author_sort | Liliana Aguayo |
| collection | DOAJ |
| description | Background We investigated associations of childhood abuse with 4 cardiovascular disease risk factors in adulthood, and whether exposure to nurturing and household organization in childhood mitigated these associations. Methods and Results The CARDIA (Coronary Artery Risk Development in Young Adults) study (baseline examination, 1985–1986) was used to examine associations of childhood exposures (measured retrospectively at the year 15 examination) with incident obesity, type 2 diabetes, hypertension, and hyperlipidemia (assessed from baseline to year 30). Race‐ and sex‐stratified Cox proportional hazards models were used to examine associations of exposure to childhood abuse with incident cardiovascular disease risk factors. Interaction terms between exposure to abuse and exposure to nurturing relationship and household organization were included to test for effect modifications. Exposure to occasional/frequent abuse (versus no abuse) was associated with incident type 2 diabetes among White men (hazard ratio [HR], 1.81; 95% CI, 1.06–3.08). Exposure to low versus no abuse was associated with incident hyperlipidemia among White men (HR, 1.35; 95% CI, 1.09–1.67) and White women (HR, 1.26; 95% CI, 1.01–1.56). Risks of incident hyperlipidemia were higher for White women who experienced abuse and lived in dysfunctional households (HR, 3.61; 95% CI, 1.62–8.05) or households with low levels of organization (HR, 2.05; 95% CI, 1.25–3.36) compared with White women who experienced abuse but lived in well‐organized households (HR, 0.66; 95% CI, 0.41–1.06). Similar patterns were seen for Black men who lived in dysfunctional households (HR, 3.62; 95% CI, 1.29–10.12) or households with low organization (HR, 2.01; 95% CI, 1.08–3.72). Conclusions We identified race‐ and sex‐specific associations of childhood exposures with incident cardiovascular disease risk factors. The associations of household organization and dysfunction with cardiovascular disease risks merits further investigation. |
| first_indexed | 2024-04-12T20:54:14Z |
| format | Article |
| id | doaj.art-fc2d4039438449b1950d6acaa24489ae |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-12T20:54:14Z |
| publishDate | 2022-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-fc2d4039438449b1950d6acaa24489ae2022-12-22T03:17:02ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802022-05-0111910.1161/JAHA.121.023244Association of Exposure to Abuse, Nurture, and Household Organization in Childhood With 4 Cardiovascular Disease Risks Factors Among Participants in the CARDIA StudyLiliana Aguayo0Diana A. Chirinos1Nia Heard‐Garris2Mandy Wong3Matthew M. Davis4Sharon Stein Merkin5Teresa Seeman6Kiarri N. Kershaw7Department of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago ILDepartment of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago ILMary Ann & J. Milburn Smith Child Health Outreach, Research, and Evaluation CenterStanley Manne Children's Research InstituteAnn & Robert H. Lurie Children's Hospital Chicago ILDepartment of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago ILDepartment of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago ILDivision of Geriatrics Los Angeles Geffen School of MedicineUniversity of California Los Angeles CADivision of Geriatrics Los Angeles Geffen School of MedicineUniversity of California Los Angeles CADepartment of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago ILBackground We investigated associations of childhood abuse with 4 cardiovascular disease risk factors in adulthood, and whether exposure to nurturing and household organization in childhood mitigated these associations. Methods and Results The CARDIA (Coronary Artery Risk Development in Young Adults) study (baseline examination, 1985–1986) was used to examine associations of childhood exposures (measured retrospectively at the year 15 examination) with incident obesity, type 2 diabetes, hypertension, and hyperlipidemia (assessed from baseline to year 30). Race‐ and sex‐stratified Cox proportional hazards models were used to examine associations of exposure to childhood abuse with incident cardiovascular disease risk factors. Interaction terms between exposure to abuse and exposure to nurturing relationship and household organization were included to test for effect modifications. Exposure to occasional/frequent abuse (versus no abuse) was associated with incident type 2 diabetes among White men (hazard ratio [HR], 1.81; 95% CI, 1.06–3.08). Exposure to low versus no abuse was associated with incident hyperlipidemia among White men (HR, 1.35; 95% CI, 1.09–1.67) and White women (HR, 1.26; 95% CI, 1.01–1.56). Risks of incident hyperlipidemia were higher for White women who experienced abuse and lived in dysfunctional households (HR, 3.61; 95% CI, 1.62–8.05) or households with low levels of organization (HR, 2.05; 95% CI, 1.25–3.36) compared with White women who experienced abuse but lived in well‐organized households (HR, 0.66; 95% CI, 0.41–1.06). Similar patterns were seen for Black men who lived in dysfunctional households (HR, 3.62; 95% CI, 1.29–10.12) or households with low organization (HR, 2.01; 95% CI, 1.08–3.72). Conclusions We identified race‐ and sex‐specific associations of childhood exposures with incident cardiovascular disease risk factors. The associations of household organization and dysfunction with cardiovascular disease risks merits further investigation.https://www.ahajournals.org/doi/10.1161/JAHA.121.023244childhoodchildhood exposureshyperlipidemiahypertensionobesitytype 2 diabetes |
| spellingShingle | Liliana Aguayo Diana A. Chirinos Nia Heard‐Garris Mandy Wong Matthew M. Davis Sharon Stein Merkin Teresa Seeman Kiarri N. Kershaw Association of Exposure to Abuse, Nurture, and Household Organization in Childhood With 4 Cardiovascular Disease Risks Factors Among Participants in the CARDIA Study Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease childhood childhood exposures hyperlipidemia hypertension obesity type 2 diabetes |
| title | Association of Exposure to Abuse, Nurture, and Household Organization in Childhood With 4 Cardiovascular Disease Risks Factors Among Participants in the CARDIA Study |
| title_full | Association of Exposure to Abuse, Nurture, and Household Organization in Childhood With 4 Cardiovascular Disease Risks Factors Among Participants in the CARDIA Study |
| title_fullStr | Association of Exposure to Abuse, Nurture, and Household Organization in Childhood With 4 Cardiovascular Disease Risks Factors Among Participants in the CARDIA Study |
| title_full_unstemmed | Association of Exposure to Abuse, Nurture, and Household Organization in Childhood With 4 Cardiovascular Disease Risks Factors Among Participants in the CARDIA Study |
| title_short | Association of Exposure to Abuse, Nurture, and Household Organization in Childhood With 4 Cardiovascular Disease Risks Factors Among Participants in the CARDIA Study |
| title_sort | association of exposure to abuse nurture and household organization in childhood with 4 cardiovascular disease risks factors among participants in the cardia study |
| topic | childhood childhood exposures hyperlipidemia hypertension obesity type 2 diabetes |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.121.023244 |
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