Risk factors for the development of bronchiolitis obliterans in children after suffering from adenovirus pneumonia
IntroductionBronchiolitis obliterans (BO) is an irreversible chronic obstructive lung disease in small airways. The aim of this study was to identify the relevant risk factors for the development of BO in children after suffering from adenovirus (ADV) pneumonia.MethodsAn observational cohort study t...
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| Format: | Article |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1335543/full |
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| author | Jiahao Yuan Mengyue Wei Manke Chen Ruizhu Wang Jialing Diao Man Tian Deyu Zhao Meng Chen |
| author_facet | Jiahao Yuan Mengyue Wei Manke Chen Ruizhu Wang Jialing Diao Man Tian Deyu Zhao Meng Chen |
| author_sort | Jiahao Yuan |
| collection | DOAJ |
| description | IntroductionBronchiolitis obliterans (BO) is an irreversible chronic obstructive lung disease in small airways. The aim of this study was to identify the relevant risk factors for the development of BO in children after suffering from adenovirus (ADV) pneumonia.MethodsAn observational cohort study that included 112 children suffering from ADV pneumonia in our institution from March 2019 to March 2020 was performed. We divided the children into a BO group and a non-BO group based on whether they did develop BO or not. Univariate analysis and multivariate logistic regression analysis were applied to identify risk factors for the development of BO. The prediction probability model was evaluated by receiver operating characteristic (ROC) curve analysis.ResultsTwenty-eight children (25%) did develop BO after suffering from ADV pneumonia, while 84 children did not. Respiratory support (OR 6.772, 95% CI 2.060–22.260, P = 0.002), extended length of wheezing days (OR 1.112, 95% CI 1.040–1.189, P = 0.002) and higher lactic dehydrogenase (LDH) levels (OR 1.002, 95% CI 1.000–1.003, P = 0.012) were independently associated with the development of BO. The predictive value of this prediction probability model was validated by the ROC curve, with an area under the curve of 0.870 (95% CI 0.801–0.939, P < 0.001), a standard error of 0.035, a maximum Youden's index of 0.608, a sensitivity of 0.929, and a specificity of 0.679.ConclusionsAfter suffering an ADV pneumonia, children who have needed respiratory support, had a longer length of wheezing days or had higher LDH levels are more likely to develop BO. |
| first_indexed | 2024-03-08T15:32:12Z |
| format | Article |
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| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-03-08T15:32:12Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-fc2e728947fb4bed92ec14874ff318902024-01-10T04:27:32ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602024-01-011110.3389/fped.2023.13355431335543Risk factors for the development of bronchiolitis obliterans in children after suffering from adenovirus pneumoniaJiahao Yuan0Mengyue Wei1Manke Chen2Ruizhu Wang3Jialing Diao4Man Tian5Deyu Zhao6Meng Chen7Department of Respiratory Medicine, Children’s Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Respiratory Medicine, Children’s Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Respiratory Medicine, Children’s Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, Children’s Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Respiratory Medicine, Children’s Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Respiratory Medicine, Children’s Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Respiratory Medicine, Children’s Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Respiratory Medicine, Children’s Hospital of Nanjing Medical University, Nanjing, ChinaIntroductionBronchiolitis obliterans (BO) is an irreversible chronic obstructive lung disease in small airways. The aim of this study was to identify the relevant risk factors for the development of BO in children after suffering from adenovirus (ADV) pneumonia.MethodsAn observational cohort study that included 112 children suffering from ADV pneumonia in our institution from March 2019 to March 2020 was performed. We divided the children into a BO group and a non-BO group based on whether they did develop BO or not. Univariate analysis and multivariate logistic regression analysis were applied to identify risk factors for the development of BO. The prediction probability model was evaluated by receiver operating characteristic (ROC) curve analysis.ResultsTwenty-eight children (25%) did develop BO after suffering from ADV pneumonia, while 84 children did not. Respiratory support (OR 6.772, 95% CI 2.060–22.260, P = 0.002), extended length of wheezing days (OR 1.112, 95% CI 1.040–1.189, P = 0.002) and higher lactic dehydrogenase (LDH) levels (OR 1.002, 95% CI 1.000–1.003, P = 0.012) were independently associated with the development of BO. The predictive value of this prediction probability model was validated by the ROC curve, with an area under the curve of 0.870 (95% CI 0.801–0.939, P < 0.001), a standard error of 0.035, a maximum Youden's index of 0.608, a sensitivity of 0.929, and a specificity of 0.679.ConclusionsAfter suffering an ADV pneumonia, children who have needed respiratory support, had a longer length of wheezing days or had higher LDH levels are more likely to develop BO.https://www.frontiersin.org/articles/10.3389/fped.2023.1335543/fulladenovirus pneumoniabronchiolitis obliteranschildrenlogistic regression analysisrisk factors |
| spellingShingle | Jiahao Yuan Mengyue Wei Manke Chen Ruizhu Wang Jialing Diao Man Tian Deyu Zhao Meng Chen Risk factors for the development of bronchiolitis obliterans in children after suffering from adenovirus pneumonia Frontiers in Pediatrics adenovirus pneumonia bronchiolitis obliterans children logistic regression analysis risk factors |
| title | Risk factors for the development of bronchiolitis obliterans in children after suffering from adenovirus pneumonia |
| title_full | Risk factors for the development of bronchiolitis obliterans in children after suffering from adenovirus pneumonia |
| title_fullStr | Risk factors for the development of bronchiolitis obliterans in children after suffering from adenovirus pneumonia |
| title_full_unstemmed | Risk factors for the development of bronchiolitis obliterans in children after suffering from adenovirus pneumonia |
| title_short | Risk factors for the development of bronchiolitis obliterans in children after suffering from adenovirus pneumonia |
| title_sort | risk factors for the development of bronchiolitis obliterans in children after suffering from adenovirus pneumonia |
| topic | adenovirus pneumonia bronchiolitis obliterans children logistic regression analysis risk factors |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.1335543/full |
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