Mechanosignals in abdominal aortic aneurysms
Cumulative evidence has shown that mechanical and frictional forces exert distinct effects in the multi-cellular aortic layers and play a significant role in the development of abdominal aortic aneurysms (AAA). These mechanical cues collectively trigger signaling cascades relying on mechanosensory c...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1021934/full |
| _version_ | 1797957742331166720 |
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| author | Christiana Lowis Christiana Lowis Aurellia Ramara Winaya Aurellia Ramara Winaya Puja Kumari Puja Kumari Cristobal F. Rivera Cristobal F. Rivera John Vlahos John Vlahos Rio Hermantara Muhammad Yogi Pratama Muhammad Yogi Pratama Bhama Ramkhelawon Bhama Ramkhelawon |
| author_facet | Christiana Lowis Christiana Lowis Aurellia Ramara Winaya Aurellia Ramara Winaya Puja Kumari Puja Kumari Cristobal F. Rivera Cristobal F. Rivera John Vlahos John Vlahos Rio Hermantara Muhammad Yogi Pratama Muhammad Yogi Pratama Bhama Ramkhelawon Bhama Ramkhelawon |
| author_sort | Christiana Lowis |
| collection | DOAJ |
| description | Cumulative evidence has shown that mechanical and frictional forces exert distinct effects in the multi-cellular aortic layers and play a significant role in the development of abdominal aortic aneurysms (AAA). These mechanical cues collectively trigger signaling cascades relying on mechanosensory cellular hubs that regulate vascular remodeling programs leading to the exaggerated degradation of the extracellular matrix (ECM), culminating in lethal aortic rupture. In this review, we provide an update and summarize the current understanding of the mechanotransduction networks in different cell types during AAA development. We focus on different mechanosensors and stressors that accumulate in the AAA sac and the mechanotransduction cascades that contribute to inflammation, oxidative stress, remodeling, and ECM degradation. We provide perspectives on manipulating this mechano-machinery as a new direction for future research in AAA. |
| first_indexed | 2024-04-11T00:09:24Z |
| format | Article |
| id | doaj.art-fc2fa576a69e476ab3821dd76795b234 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-11T00:09:24Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-fc2fa576a69e476ab3821dd76795b2342023-01-09T08:26:30ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-01-01910.3389/fcvm.2022.10219341021934Mechanosignals in abdominal aortic aneurysmsChristiana Lowis0Christiana Lowis1Aurellia Ramara Winaya2Aurellia Ramara Winaya3Puja Kumari4Puja Kumari5Cristobal F. Rivera6Cristobal F. Rivera7John Vlahos8John Vlahos9Rio Hermantara10Muhammad Yogi Pratama11Muhammad Yogi Pratama12Bhama Ramkhelawon13Bhama Ramkhelawon14Division of Vascular and Endovascular Surgery, Department of Surgery, New York University Langone Medical Center, New York, NY, United StatesDepartment of Biomedicine, Indonesia International Institute for Life-Sciences, Jakarta, IndonesiaDivision of Vascular and Endovascular Surgery, Department of Surgery, New York University Langone Medical Center, New York, NY, United StatesDepartment of Biomedicine, Indonesia International Institute for Life-Sciences, Jakarta, IndonesiaDivision of Vascular and Endovascular Surgery, Department of Surgery, New York University Langone Medical Center, New York, NY, United StatesDepartment of Cell Biology, New York University Langone Medical Center, New York, NY, United StatesDivision of Vascular and Endovascular Surgery, Department of Surgery, New York University Langone Medical Center, New York, NY, United StatesDepartment of Cell Biology, New York University Langone Medical Center, New York, NY, United StatesDivision of Vascular and Endovascular Surgery, Department of Surgery, New York University Langone Medical Center, New York, NY, United StatesDepartment of Cell Biology, New York University Langone Medical Center, New York, NY, United StatesDepartment of Biomedicine, Indonesia International Institute for Life-Sciences, Jakarta, IndonesiaDivision of Vascular and Endovascular Surgery, Department of Surgery, New York University Langone Medical Center, New York, NY, United StatesDepartment of Cell Biology, New York University Langone Medical Center, New York, NY, United StatesDivision of Vascular and Endovascular Surgery, Department of Surgery, New York University Langone Medical Center, New York, NY, United StatesDepartment of Cell Biology, New York University Langone Medical Center, New York, NY, United StatesCumulative evidence has shown that mechanical and frictional forces exert distinct effects in the multi-cellular aortic layers and play a significant role in the development of abdominal aortic aneurysms (AAA). These mechanical cues collectively trigger signaling cascades relying on mechanosensory cellular hubs that regulate vascular remodeling programs leading to the exaggerated degradation of the extracellular matrix (ECM), culminating in lethal aortic rupture. In this review, we provide an update and summarize the current understanding of the mechanotransduction networks in different cell types during AAA development. We focus on different mechanosensors and stressors that accumulate in the AAA sac and the mechanotransduction cascades that contribute to inflammation, oxidative stress, remodeling, and ECM degradation. We provide perspectives on manipulating this mechano-machinery as a new direction for future research in AAA.https://www.frontiersin.org/articles/10.3389/fcvm.2022.1021934/fullabdominal aortic aneurysmmechanosignalsshear stressmechanotransductionmechanical stressvascular pathology |
| spellingShingle | Christiana Lowis Christiana Lowis Aurellia Ramara Winaya Aurellia Ramara Winaya Puja Kumari Puja Kumari Cristobal F. Rivera Cristobal F. Rivera John Vlahos John Vlahos Rio Hermantara Muhammad Yogi Pratama Muhammad Yogi Pratama Bhama Ramkhelawon Bhama Ramkhelawon Mechanosignals in abdominal aortic aneurysms Frontiers in Cardiovascular Medicine abdominal aortic aneurysm mechanosignals shear stress mechanotransduction mechanical stress vascular pathology |
| title | Mechanosignals in abdominal aortic aneurysms |
| title_full | Mechanosignals in abdominal aortic aneurysms |
| title_fullStr | Mechanosignals in abdominal aortic aneurysms |
| title_full_unstemmed | Mechanosignals in abdominal aortic aneurysms |
| title_short | Mechanosignals in abdominal aortic aneurysms |
| title_sort | mechanosignals in abdominal aortic aneurysms |
| topic | abdominal aortic aneurysm mechanosignals shear stress mechanotransduction mechanical stress vascular pathology |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1021934/full |
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