Discovery of Substituted Hydroxylphenyl Pyrimidine-2(1H) Thione as a New Series of Antioxidant using AAU and AAI Method
A series of substituted pyrimidine has been discovered as a new class of potent antioxidant. 6-(Substituted aldehyde)- 3,4-dihydro-1-(tetrahydro-3,4-dihydroxy-5-hydroxymethyl)furan-2-yl)-4-(4-hydroxyphenyl)pyrimidine-2(1H)-thione derivative (XVII-XXIV) was synthesized from the 6-(Substituted aldehyd...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Walailak University
2014-07-01
|
| Series: | Walailak Journal of Science and Technology |
| Subjects: | |
| Online Access: | http://wjst.wu.ac.th/index.php/wjst/article/view/471 |
| _version_ | 1818525068701990912 |
|---|---|
| author | Rupesh DUDHE Pramod Kumar SHARMA Prabhaker Kumar VERMA |
| author_facet | Rupesh DUDHE Pramod Kumar SHARMA Prabhaker Kumar VERMA |
| author_sort | Rupesh DUDHE |
| collection | DOAJ |
| description | A series of substituted pyrimidine has been discovered as a new class of potent antioxidant. 6-(Substituted aldehyde)- 3,4-dihydro-1-(tetrahydro-3,4-dihydroxy-5-hydroxymethyl)furan-2-yl)-4-(4-hydroxyphenyl)pyrimidine-2(1H)-thione derivative (XVII-XXIV) was synthesized from the 6-(Substituted aldehyde) -4-phenylpyrimidine-2(1H)-thione derivative (IX-XVI) through the reaction mechanisms of Claisen-Schmidt, Cyclization and Satos fusion. The structures of the synthesized compounds were elucidated by I.R., 1H-NMR, elemental analysis and mass spectroscopic techniques. The synthesized compounds were screened for in vitro antioxidant activity using the DPPH assay, based on the AAI and AAU, using a combination relation between DPPH concentration and absorbance. The antioxidant strength of compounds was compared against ascorbic acid. Among them, compounds XVII, XX, XIX and XXIV exhibited significant antioxidant activity, as seen by using the free radical scavenging (DPPH) method.
doi:10.14456/WJST.2015.83 |
| first_indexed | 2024-12-11T06:04:49Z |
| format | Article |
| id | doaj.art-fc302d0b3a794f6797bf6f3941539ea3 |
| institution | Directory Open Access Journal |
| issn | 1686-3933 2228-835X |
| language | English |
| last_indexed | 2024-12-11T06:04:49Z |
| publishDate | 2014-07-01 |
| publisher | Walailak University |
| record_format | Article |
| series | Walailak Journal of Science and Technology |
| spelling | doaj.art-fc302d0b3a794f6797bf6f3941539ea32022-12-22T01:18:20ZengWalailak UniversityWalailak Journal of Science and Technology1686-39332228-835X2014-07-0112510.14456/471473Discovery of Substituted Hydroxylphenyl Pyrimidine-2(1H) Thione as a New Series of Antioxidant using AAU and AAI MethodRupesh DUDHE0Pramod Kumar SHARMA1Prabhaker Kumar VERMA2Uttarakhand Technical University, Uttarakhand, Dehradun 284007Department of Pharmacy, Galgotias University, Uttar Pradesh 201306Maharshi Dayanand University, Haryana 124001A series of substituted pyrimidine has been discovered as a new class of potent antioxidant. 6-(Substituted aldehyde)- 3,4-dihydro-1-(tetrahydro-3,4-dihydroxy-5-hydroxymethyl)furan-2-yl)-4-(4-hydroxyphenyl)pyrimidine-2(1H)-thione derivative (XVII-XXIV) was synthesized from the 6-(Substituted aldehyde) -4-phenylpyrimidine-2(1H)-thione derivative (IX-XVI) through the reaction mechanisms of Claisen-Schmidt, Cyclization and Satos fusion. The structures of the synthesized compounds were elucidated by I.R., 1H-NMR, elemental analysis and mass spectroscopic techniques. The synthesized compounds were screened for in vitro antioxidant activity using the DPPH assay, based on the AAI and AAU, using a combination relation between DPPH concentration and absorbance. The antioxidant strength of compounds was compared against ascorbic acid. Among them, compounds XVII, XX, XIX and XXIV exhibited significant antioxidant activity, as seen by using the free radical scavenging (DPPH) method. doi:10.14456/WJST.2015.83http://wjst.wu.ac.th/index.php/wjst/article/view/471PyrimidineantioxidantDPPHAAU |
| spellingShingle | Rupesh DUDHE Pramod Kumar SHARMA Prabhaker Kumar VERMA Discovery of Substituted Hydroxylphenyl Pyrimidine-2(1H) Thione as a New Series of Antioxidant using AAU and AAI Method Walailak Journal of Science and Technology Pyrimidine antioxidant DPPH AAU |
| title | Discovery of Substituted Hydroxylphenyl Pyrimidine-2(1H) Thione as a New Series of Antioxidant using AAU and AAI Method |
| title_full | Discovery of Substituted Hydroxylphenyl Pyrimidine-2(1H) Thione as a New Series of Antioxidant using AAU and AAI Method |
| title_fullStr | Discovery of Substituted Hydroxylphenyl Pyrimidine-2(1H) Thione as a New Series of Antioxidant using AAU and AAI Method |
| title_full_unstemmed | Discovery of Substituted Hydroxylphenyl Pyrimidine-2(1H) Thione as a New Series of Antioxidant using AAU and AAI Method |
| title_short | Discovery of Substituted Hydroxylphenyl Pyrimidine-2(1H) Thione as a New Series of Antioxidant using AAU and AAI Method |
| title_sort | discovery of substituted hydroxylphenyl pyrimidine 2 1h thione as a new series of antioxidant using aau and aai method |
| topic | Pyrimidine antioxidant DPPH AAU |
| url | http://wjst.wu.ac.th/index.php/wjst/article/view/471 |
| work_keys_str_mv | AT rupeshdudhe discoveryofsubstitutedhydroxylphenylpyrimidine21hthioneasanewseriesofantioxidantusingaauandaaimethod AT pramodkumarsharma discoveryofsubstitutedhydroxylphenylpyrimidine21hthioneasanewseriesofantioxidantusingaauandaaimethod AT prabhakerkumarverma discoveryofsubstitutedhydroxylphenylpyrimidine21hthioneasanewseriesofantioxidantusingaauandaaimethod |