<sup>18</sup>F-FDG PET/CT-based gross tumor volume definition for radiotherapy in head and neck Cancer: a correlation study between suitable uptake value threshold and tumor parameters
<p>Abstract</p> <p>Background</p> <p>To define a suitable threshold setting for gross tumor volume (GTV) when using <sup>18</sup>Fluoro-deoxyglucose positron emission tomography and computed tomogram (PET/CT) for radiotherapy planning in head and neck cancer...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2010-09-01
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| Series: | Radiation Oncology |
| Online Access: | http://www.ro-journal.com/content/5/1/76 |
| _version_ | 1818063852788514816 |
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| author | Kao Chia-Hung Hsieh Te-Chun Yu Chun-Yen Yen Kuo-Yang Yang Shih-Neng Wang Yao-Ching Liang Ji-An Chien Chun-Ru Chen Shang-Wen |
| author_facet | Kao Chia-Hung Hsieh Te-Chun Yu Chun-Yen Yen Kuo-Yang Yang Shih-Neng Wang Yao-Ching Liang Ji-An Chien Chun-Ru Chen Shang-Wen |
| author_sort | Kao Chia-Hung |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>To define a suitable threshold setting for gross tumor volume (GTV) when using <sup>18</sup>Fluoro-deoxyglucose positron emission tomography and computed tomogram (PET/CT) for radiotherapy planning in head and neck cancer (HNC).</p> <p>Methods</p> <p>Fifteen HNC patients prospectively received PET/CT simulation for their radiation treatment planning. Biological target volume (BTV) was derived from PET/CT-based GTV of the primary tumor. The BTVs were defined as the isodensity volumes when adjusting different percentage of the maximal standardized uptake value (SUVmax), excluding any artifact from surrounding normal tissues. CT-based primary GTV (C-pGTV) that had been previously defined by radiation oncologists was compared with the BTV. Suitable threshold level (sTL) could be determined when BTV value and its morphology using a certain threshold level was observed to be the best fitness of the C-pGTV. Suitable standardized uptake value (sSUV) was calculated as the sTL multiplied by the SUVmax.</p> <p>Results</p> <p>Our result demonstrated no single sTL or sSUV method could achieve an optimized volumetric match with the C-pGTV. The sTL was 13% to 27% (mean, 19%), whereas the sSUV was 1.64 to 3.98 (mean, 2.46). The sTL was inversely correlated with the SUVmax [sTL = -0.1004 Ln (SUVmax) + 0.4464; R<sup>2 </sup>= 0.81]. The sSUV showed a linear correlation with the SUVmax (sSUV = 0.0842 SUVmax + 1.248; R<sup>2 </sup>= 0.89). The sTL was not associated with the value of C-pGTVs.</p> <p>Conclusion</p> <p>In PET/CT-based BTV for HNC, a suitable threshold or SUV level can be established by correlating with SUVmax rather than using a fixed threshold.</p> |
| first_indexed | 2024-12-10T14:26:41Z |
| format | Article |
| id | doaj.art-fc30565ccd8c4c7892e812067b28321a |
| institution | Directory Open Access Journal |
| issn | 1748-717X |
| language | English |
| last_indexed | 2024-12-10T14:26:41Z |
| publishDate | 2010-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj.art-fc30565ccd8c4c7892e812067b28321a2022-12-22T01:45:04ZengBMCRadiation Oncology1748-717X2010-09-01517610.1186/1748-717X-5-76<sup>18</sup>F-FDG PET/CT-based gross tumor volume definition for radiotherapy in head and neck Cancer: a correlation study between suitable uptake value threshold and tumor parametersKao Chia-HungHsieh Te-ChunYu Chun-YenYen Kuo-YangYang Shih-NengWang Yao-ChingLiang Ji-AnChien Chun-RuChen Shang-Wen<p>Abstract</p> <p>Background</p> <p>To define a suitable threshold setting for gross tumor volume (GTV) when using <sup>18</sup>Fluoro-deoxyglucose positron emission tomography and computed tomogram (PET/CT) for radiotherapy planning in head and neck cancer (HNC).</p> <p>Methods</p> <p>Fifteen HNC patients prospectively received PET/CT simulation for their radiation treatment planning. Biological target volume (BTV) was derived from PET/CT-based GTV of the primary tumor. The BTVs were defined as the isodensity volumes when adjusting different percentage of the maximal standardized uptake value (SUVmax), excluding any artifact from surrounding normal tissues. CT-based primary GTV (C-pGTV) that had been previously defined by radiation oncologists was compared with the BTV. Suitable threshold level (sTL) could be determined when BTV value and its morphology using a certain threshold level was observed to be the best fitness of the C-pGTV. Suitable standardized uptake value (sSUV) was calculated as the sTL multiplied by the SUVmax.</p> <p>Results</p> <p>Our result demonstrated no single sTL or sSUV method could achieve an optimized volumetric match with the C-pGTV. The sTL was 13% to 27% (mean, 19%), whereas the sSUV was 1.64 to 3.98 (mean, 2.46). The sTL was inversely correlated with the SUVmax [sTL = -0.1004 Ln (SUVmax) + 0.4464; R<sup>2 </sup>= 0.81]. The sSUV showed a linear correlation with the SUVmax (sSUV = 0.0842 SUVmax + 1.248; R<sup>2 </sup>= 0.89). The sTL was not associated with the value of C-pGTVs.</p> <p>Conclusion</p> <p>In PET/CT-based BTV for HNC, a suitable threshold or SUV level can be established by correlating with SUVmax rather than using a fixed threshold.</p>http://www.ro-journal.com/content/5/1/76 |
| spellingShingle | Kao Chia-Hung Hsieh Te-Chun Yu Chun-Yen Yen Kuo-Yang Yang Shih-Neng Wang Yao-Ching Liang Ji-An Chien Chun-Ru Chen Shang-Wen <sup>18</sup>F-FDG PET/CT-based gross tumor volume definition for radiotherapy in head and neck Cancer: a correlation study between suitable uptake value threshold and tumor parameters Radiation Oncology |
| title | <sup>18</sup>F-FDG PET/CT-based gross tumor volume definition for radiotherapy in head and neck Cancer: a correlation study between suitable uptake value threshold and tumor parameters |
| title_full | <sup>18</sup>F-FDG PET/CT-based gross tumor volume definition for radiotherapy in head and neck Cancer: a correlation study between suitable uptake value threshold and tumor parameters |
| title_fullStr | <sup>18</sup>F-FDG PET/CT-based gross tumor volume definition for radiotherapy in head and neck Cancer: a correlation study between suitable uptake value threshold and tumor parameters |
| title_full_unstemmed | <sup>18</sup>F-FDG PET/CT-based gross tumor volume definition for radiotherapy in head and neck Cancer: a correlation study between suitable uptake value threshold and tumor parameters |
| title_short | <sup>18</sup>F-FDG PET/CT-based gross tumor volume definition for radiotherapy in head and neck Cancer: a correlation study between suitable uptake value threshold and tumor parameters |
| title_sort | sup 18 sup f fdg pet ct based gross tumor volume definition for radiotherapy in head and neck cancer a correlation study between suitable uptake value threshold and tumor parameters |
| url | http://www.ro-journal.com/content/5/1/76 |
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