Neurotrophins and Spinal Circuit Function
Abstract: Work early in the last century emphasized the stereotyped activity of spinal circuits based on studies of reflexes. However, the last several decades have focused on the plasticity of these spinal circuits. These considerations began with studies of the effects of monoamines on descending...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2014-06-01
|
| Series: | Frontiers in Neural Circuits |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncir.2014.00059/full |
| _version_ | 1818615741864214528 |
|---|---|
| author | Vanessa S. Boyce Lorne M. Mendell |
| author_facet | Vanessa S. Boyce Lorne M. Mendell |
| author_sort | Vanessa S. Boyce |
| collection | DOAJ |
| description | Abstract: Work early in the last century emphasized the stereotyped activity of spinal circuits based on studies of reflexes. However, the last several decades have focused on the plasticity of these spinal circuits. These considerations began with studies of the effects of monoamines on descending and reflex circuits. In recent years new classes of compounds called growth factors that are found in peripheral nerves and the spinal cord have been shown to affect circuit behavior in the spinal cord. In this review we will focus on the effects of neurotrophins, particularly NGF, BDNF and NT-3, on spinal circuits. We also discuss evidence that these molecules can modify functions including nociceptive behavior, motor reflexes and stepping behavior. Since these substances and their receptors are normally present in the spinal cord, they could potentially be useful in improving function in disease states and after injury. Here we review recent findings relevant to these translational issues. |
| first_indexed | 2024-12-16T16:38:44Z |
| format | Article |
| id | doaj.art-fc315dc846914aef821a5a8760cd8e58 |
| institution | Directory Open Access Journal |
| issn | 1662-5110 |
| language | English |
| last_indexed | 2024-12-16T16:38:44Z |
| publishDate | 2014-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neural Circuits |
| spelling | doaj.art-fc315dc846914aef821a5a8760cd8e582022-12-21T22:24:23ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102014-06-01810.3389/fncir.2014.0005989411Neurotrophins and Spinal Circuit FunctionVanessa S. Boyce0Lorne M. Mendell1Stony Brook UniversityStony Brook UniversityAbstract: Work early in the last century emphasized the stereotyped activity of spinal circuits based on studies of reflexes. However, the last several decades have focused on the plasticity of these spinal circuits. These considerations began with studies of the effects of monoamines on descending and reflex circuits. In recent years new classes of compounds called growth factors that are found in peripheral nerves and the spinal cord have been shown to affect circuit behavior in the spinal cord. In this review we will focus on the effects of neurotrophins, particularly NGF, BDNF and NT-3, on spinal circuits. We also discuss evidence that these molecules can modify functions including nociceptive behavior, motor reflexes and stepping behavior. Since these substances and their receptors are normally present in the spinal cord, they could potentially be useful in improving function in disease states and after injury. Here we review recent findings relevant to these translational issues.http://journal.frontiersin.org/Journal/10.3389/fncir.2014.00059/fullLocomotionPainBDNFcentral pattern generatormotoneuronNGF |
| spellingShingle | Vanessa S. Boyce Lorne M. Mendell Neurotrophins and Spinal Circuit Function Frontiers in Neural Circuits Locomotion Pain BDNF central pattern generator motoneuron NGF |
| title | Neurotrophins and Spinal Circuit Function |
| title_full | Neurotrophins and Spinal Circuit Function |
| title_fullStr | Neurotrophins and Spinal Circuit Function |
| title_full_unstemmed | Neurotrophins and Spinal Circuit Function |
| title_short | Neurotrophins and Spinal Circuit Function |
| title_sort | neurotrophins and spinal circuit function |
| topic | Locomotion Pain BDNF central pattern generator motoneuron NGF |
| url | http://journal.frontiersin.org/Journal/10.3389/fncir.2014.00059/full |
| work_keys_str_mv | AT vanessasboyce neurotrophinsandspinalcircuitfunction AT lornemmendell neurotrophinsandspinalcircuitfunction |