Threat experiences moderate the link between hippocampus volume and depression symptoms prospectively in adolescence
Identifying neuroimaging risk markers for depression has been an elusive goal in psychopathology research. Despite this, smaller hippocampal volume has emerged as a potential risk marker for depression, with recent research suggesting this association is moderated by family income. The current pre-r...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Developmental Cognitive Neuroscience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929324000203 |
| _version_ | 1797198826075848704 |
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| author | Max P. Herzberg Meriah L. DeJoseph Joan Luby Deanna M. Barch |
| author_facet | Max P. Herzberg Meriah L. DeJoseph Joan Luby Deanna M. Barch |
| author_sort | Max P. Herzberg |
| collection | DOAJ |
| description | Identifying neuroimaging risk markers for depression has been an elusive goal in psychopathology research. Despite this, smaller hippocampal volume has emerged as a potential risk marker for depression, with recent research suggesting this association is moderated by family income. The current pre-registered study aimed to replicate and extend these findings by examining the moderating role of family income and three dimensions of environmental experience on the link between hippocampus volume and later depression. Data were drawn from the Adolescent Brain Cognitive Development (ABCD) study and were comprised of 6693 youth aged 9–10 years at baseline. Results indicated that psychosocial threat moderated the association between right hippocampus volume and depression symptoms two years later, such that a negative association was evident in low-threat environments (std. beta=0.15, 95% CI [0.05, 0.24]). This interaction remained significant when baseline depression symptoms were included as a covariate, though only in youth endorsing 1 or more depression symptoms at baseline (β = 0.13, 95% CI = [0.03, 0.22]). These results suggest that hippocampus volume may not be a consistent correlate of depression symptoms in high risk environments and emphasize the importance of including measures of environmental heterogeneity when seeking risk markers for depression. |
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| format | Article |
| id | doaj.art-fc32bf85c838454db63263a3d8424a7d |
| institution | Directory Open Access Journal |
| issn | 1878-9293 |
| language | English |
| last_indexed | 2024-04-24T07:06:01Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj.art-fc32bf85c838454db63263a3d8424a7d2024-04-22T04:11:35ZengElsevierDevelopmental Cognitive Neuroscience1878-92932024-04-0166101359Threat experiences moderate the link between hippocampus volume and depression symptoms prospectively in adolescenceMax P. Herzberg0Meriah L. DeJoseph1Joan Luby2Deanna M. Barch3Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA; Corresponding author.Graduate School of Education, Stanford University, Stanford, CA, USADepartment of Psychiatry, Washington University in St. Louis, St. Louis, MO, USADepartment of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA; Department of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, MO, USA; Department of Radiology, Washington University in St. Louis, St. Louis, MO, USAIdentifying neuroimaging risk markers for depression has been an elusive goal in psychopathology research. Despite this, smaller hippocampal volume has emerged as a potential risk marker for depression, with recent research suggesting this association is moderated by family income. The current pre-registered study aimed to replicate and extend these findings by examining the moderating role of family income and three dimensions of environmental experience on the link between hippocampus volume and later depression. Data were drawn from the Adolescent Brain Cognitive Development (ABCD) study and were comprised of 6693 youth aged 9–10 years at baseline. Results indicated that psychosocial threat moderated the association between right hippocampus volume and depression symptoms two years later, such that a negative association was evident in low-threat environments (std. beta=0.15, 95% CI [0.05, 0.24]). This interaction remained significant when baseline depression symptoms were included as a covariate, though only in youth endorsing 1 or more depression symptoms at baseline (β = 0.13, 95% CI = [0.03, 0.22]). These results suggest that hippocampus volume may not be a consistent correlate of depression symptoms in high risk environments and emphasize the importance of including measures of environmental heterogeneity when seeking risk markers for depression.http://www.sciencedirect.com/science/article/pii/S1878929324000203HippocampusDepressionFamily incomeThreatLongitudinal |
| spellingShingle | Max P. Herzberg Meriah L. DeJoseph Joan Luby Deanna M. Barch Threat experiences moderate the link between hippocampus volume and depression symptoms prospectively in adolescence Developmental Cognitive Neuroscience Hippocampus Depression Family income Threat Longitudinal |
| title | Threat experiences moderate the link between hippocampus volume and depression symptoms prospectively in adolescence |
| title_full | Threat experiences moderate the link between hippocampus volume and depression symptoms prospectively in adolescence |
| title_fullStr | Threat experiences moderate the link between hippocampus volume and depression symptoms prospectively in adolescence |
| title_full_unstemmed | Threat experiences moderate the link between hippocampus volume and depression symptoms prospectively in adolescence |
| title_short | Threat experiences moderate the link between hippocampus volume and depression symptoms prospectively in adolescence |
| title_sort | threat experiences moderate the link between hippocampus volume and depression symptoms prospectively in adolescence |
| topic | Hippocampus Depression Family income Threat Longitudinal |
| url | http://www.sciencedirect.com/science/article/pii/S1878929324000203 |
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