Contrast-Enhanced Cone-Beam Breast CT: An Analysis of Diagnostic Value in Predicting Breast Lesion With Rim Enhancement Malignancy
BackgroundThe objective of the current study was to investigate the diagnostic value of contrast-enhanced cone-beam breast computed tomography (CE-CBBCT) for breast lesion with rim enhancement (RE).MethodsAll 36 patients were examined by non-contrast (NC-CBBCT) and contrast-enhanced CBBCT (CE-CBBCT)...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-05-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.868975/full |
| _version_ | 1811247405964722176 |
|---|---|
| author | Xin Zhao Jun Yang Yang Zuo Wei Kang Hai Liao Zhong-Tao Zheng Dan-Ke Su |
| author_facet | Xin Zhao Jun Yang Yang Zuo Wei Kang Hai Liao Zhong-Tao Zheng Dan-Ke Su |
| author_sort | Xin Zhao |
| collection | DOAJ |
| description | BackgroundThe objective of the current study was to investigate the diagnostic value of contrast-enhanced cone-beam breast computed tomography (CE-CBBCT) for breast lesion with rim enhancement (RE).MethodsAll 36 patients were examined by non-contrast (NC-CBBCT) and contrast-enhanced CBBCT (CE-CBBCT) after contrast media (CM) injection. Qualitative morphological enhancement parameters and quantitative enhancement parameters were compared between malignant and benign groups. Multivariable logistic regression analysis was performed to identify independent factors that could predict breast lesion with RE malignancy. Receiver operating curve (ROC) was used to evaluate prediction performance.ResultsA total of 36 patients with 40 lesions underwent breast CE-CBBCT were enrolled. There were significant differences in most qualitative morphological enhancement parameters between the two groups. A multivariate logistic regression model showed that △standardized HU (INRphase 2−INRpreCM) [odds ratio (OR) = 1.148, 95% CI = 1.034–1.276, p = 0.01] and △standardized HU (RPphase 2 − RPphase 1) (OR = 0.891, 95% CI = 0.814–0.976, p = 0.013) were independent indicators in predicting breast lesion with RE malignancy. △standardized HU (INRphase 2 − INRpreCM) combined with △standardized HU (RPphase 2 − RPphase 1) showed significant larger area under the receiver operating curve (AUC) and higher sensitivity than each alone (p < 0.001, AUC = 0.932, sensitivity = 92.59%, specificity = 92.31%). The regression equation of the prediction model was as follows: Logit (p) = 0.351 + 0.138X × △standardized HU (INRphase 2 − INRpreCM) − 0.115 × △standardized HU (RPphase 2 − RPphase 1).ConclusionWith the observation of qualitative morphological enhancement parameters and the comparison of quantitative enhancement parameters of CBBCT, a reliable basis for the diagnostic accuracy in predicting breast lesion with RE could be provided. These conclusions should be verified in large, well-designed studies. |
| first_indexed | 2024-04-12T15:08:16Z |
| format | Article |
| id | doaj.art-fc32f5fc321b4fda90529ce7fe9a40c5 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T15:08:16Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-fc32f5fc321b4fda90529ce7fe9a40c52022-12-22T03:27:51ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-05-011210.3389/fonc.2022.868975868975Contrast-Enhanced Cone-Beam Breast CT: An Analysis of Diagnostic Value in Predicting Breast Lesion With Rim Enhancement MalignancyXin ZhaoJun YangYang ZuoWei KangHai LiaoZhong-Tao ZhengDan-Ke SuBackgroundThe objective of the current study was to investigate the diagnostic value of contrast-enhanced cone-beam breast computed tomography (CE-CBBCT) for breast lesion with rim enhancement (RE).MethodsAll 36 patients were examined by non-contrast (NC-CBBCT) and contrast-enhanced CBBCT (CE-CBBCT) after contrast media (CM) injection. Qualitative morphological enhancement parameters and quantitative enhancement parameters were compared between malignant and benign groups. Multivariable logistic regression analysis was performed to identify independent factors that could predict breast lesion with RE malignancy. Receiver operating curve (ROC) was used to evaluate prediction performance.ResultsA total of 36 patients with 40 lesions underwent breast CE-CBBCT were enrolled. There were significant differences in most qualitative morphological enhancement parameters between the two groups. A multivariate logistic regression model showed that △standardized HU (INRphase 2−INRpreCM) [odds ratio (OR) = 1.148, 95% CI = 1.034–1.276, p = 0.01] and △standardized HU (RPphase 2 − RPphase 1) (OR = 0.891, 95% CI = 0.814–0.976, p = 0.013) were independent indicators in predicting breast lesion with RE malignancy. △standardized HU (INRphase 2 − INRpreCM) combined with △standardized HU (RPphase 2 − RPphase 1) showed significant larger area under the receiver operating curve (AUC) and higher sensitivity than each alone (p < 0.001, AUC = 0.932, sensitivity = 92.59%, specificity = 92.31%). The regression equation of the prediction model was as follows: Logit (p) = 0.351 + 0.138X × △standardized HU (INRphase 2 − INRpreCM) − 0.115 × △standardized HU (RPphase 2 − RPphase 1).ConclusionWith the observation of qualitative morphological enhancement parameters and the comparison of quantitative enhancement parameters of CBBCT, a reliable basis for the diagnostic accuracy in predicting breast lesion with RE could be provided. These conclusions should be verified in large, well-designed studies.https://www.frontiersin.org/articles/10.3389/fonc.2022.868975/fullcontrast-enhanced cone-beam breast computed tomographyclustered rim enhancementqualitative morphological enhancement parametersquantitative enhancement parametersdiagnostic accuracy |
| spellingShingle | Xin Zhao Jun Yang Yang Zuo Wei Kang Hai Liao Zhong-Tao Zheng Dan-Ke Su Contrast-Enhanced Cone-Beam Breast CT: An Analysis of Diagnostic Value in Predicting Breast Lesion With Rim Enhancement Malignancy Frontiers in Oncology contrast-enhanced cone-beam breast computed tomography clustered rim enhancement qualitative morphological enhancement parameters quantitative enhancement parameters diagnostic accuracy |
| title | Contrast-Enhanced Cone-Beam Breast CT: An Analysis of Diagnostic Value in Predicting Breast Lesion With Rim Enhancement Malignancy |
| title_full | Contrast-Enhanced Cone-Beam Breast CT: An Analysis of Diagnostic Value in Predicting Breast Lesion With Rim Enhancement Malignancy |
| title_fullStr | Contrast-Enhanced Cone-Beam Breast CT: An Analysis of Diagnostic Value in Predicting Breast Lesion With Rim Enhancement Malignancy |
| title_full_unstemmed | Contrast-Enhanced Cone-Beam Breast CT: An Analysis of Diagnostic Value in Predicting Breast Lesion With Rim Enhancement Malignancy |
| title_short | Contrast-Enhanced Cone-Beam Breast CT: An Analysis of Diagnostic Value in Predicting Breast Lesion With Rim Enhancement Malignancy |
| title_sort | contrast enhanced cone beam breast ct an analysis of diagnostic value in predicting breast lesion with rim enhancement malignancy |
| topic | contrast-enhanced cone-beam breast computed tomography clustered rim enhancement qualitative morphological enhancement parameters quantitative enhancement parameters diagnostic accuracy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.868975/full |
| work_keys_str_mv | AT xinzhao contrastenhancedconebeambreastctananalysisofdiagnosticvalueinpredictingbreastlesionwithrimenhancementmalignancy AT junyang contrastenhancedconebeambreastctananalysisofdiagnosticvalueinpredictingbreastlesionwithrimenhancementmalignancy AT yangzuo contrastenhancedconebeambreastctananalysisofdiagnosticvalueinpredictingbreastlesionwithrimenhancementmalignancy AT weikang contrastenhancedconebeambreastctananalysisofdiagnosticvalueinpredictingbreastlesionwithrimenhancementmalignancy AT hailiao contrastenhancedconebeambreastctananalysisofdiagnosticvalueinpredictingbreastlesionwithrimenhancementmalignancy AT zhongtaozheng contrastenhancedconebeambreastctananalysisofdiagnosticvalueinpredictingbreastlesionwithrimenhancementmalignancy AT dankesu contrastenhancedconebeambreastctananalysisofdiagnosticvalueinpredictingbreastlesionwithrimenhancementmalignancy |