A comparison of the acute phase proteins in chronic aortic occlusion versus diffuse aortoiliac occlusive disease
Background The purpose of the present study is to evaluate if there is a specific relationship of the acute-phase proteins between patients with the chronic aortic occlusion (COA) and patients with diffuse aortoiliac occlusive disease (AIOD), and to investigate if there is a correlation between the...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Srpsko lekarsko drustvo
2014-01-01
|
| Series: | Hospital Pharmacology |
| Subjects: | |
| Online Access: | http://scindeks-clanci.ceon.rs/data/pdf/2334-9492/2014/2334-94921401009I.pdf |
| _version_ | 1811192564523466752 |
|---|---|
| author | Ilić Nikola S. Končar Igor B. Dragaš Marko V. Golubović Milka T. Marković Miroslav D. Sladojević Miloš M. Cvetković Slobodan D. Davidović Lazar B. |
| author_facet | Ilić Nikola S. Končar Igor B. Dragaš Marko V. Golubović Milka T. Marković Miroslav D. Sladojević Miloš M. Cvetković Slobodan D. Davidović Lazar B. |
| author_sort | Ilić Nikola S. |
| collection | DOAJ |
| description | Background The purpose of the present study is to evaluate if there is a specific relationship of the acute-phase proteins between patients with the chronic aortic occlusion (COA) and patients with diffuse aortoiliac occlusive disease (AIOD), and to investigate if there is a correlation between the acute phase proteins and the extent of disease. Methods Sixty patients with the aortoiliac occlusive disease were divided in two groups. First group consisted of thirty patients with the angiographic signs of diffuse aortoiliac occlusive disease, Leriche type III (AIOD group). Second (COA) group consisted of 30 patients characterized by either bifurcated aortic occlusion or juxtarenal aortic occlusion. Those two groups were compared according to symptomatology, ankle-brachial index (ABI) values, traditional risk factors and some acute phase proteins (high-sensitivity C-reactive protein - hs-CRP; homocysteine) taken at inclusion. Results The median serum hs-CRP was 4.85 mg/L and 15.7 mg/L in AIOD group and COA group, respectively. The difference was statistically significant (p=0.016). The mean plasma homocysteine was 21.44±11.25 mmol/L and 14.76±7.85 mmol/L in the AIOD group and COA group, respectively. Mean plasma homocysteine was significantly higher in patients with AIOD (p=0.005). Conclusions Our data demonstrate significant difference in hs-CRP and homocysteine concentrations among two variants of aortoiliac occlusive disease. In this particular pathology as COA, high hs-CRP concentration does not associate, at least with the angiographic extent of disease. |
| first_indexed | 2024-04-11T23:55:47Z |
| format | Article |
| id | doaj.art-fc33db688f144b5b84bed42430d00bee |
| institution | Directory Open Access Journal |
| issn | 2334-9492 2334-9492 |
| language | English |
| last_indexed | 2024-04-11T23:55:47Z |
| publishDate | 2014-01-01 |
| publisher | Srpsko lekarsko drustvo |
| record_format | Article |
| series | Hospital Pharmacology |
| spelling | doaj.art-fc33db688f144b5b84bed42430d00bee2022-12-22T03:56:23ZengSrpsko lekarsko drustvoHospital Pharmacology2334-94922334-94922014-01-011191410.5937/hpimj1401009I2334-94921401009IA comparison of the acute phase proteins in chronic aortic occlusion versus diffuse aortoiliac occlusive diseaseIlić Nikola S.0Končar Igor B.1Dragaš Marko V.2Golubović Milka T.3Marković Miroslav D.4Sladojević Miloš M.5Cvetković Slobodan D.6Davidović Lazar B.7Klinika za vaskularnu I endovaskularnu hirurgiju, Klinički centar Srbije, Beograd + Medicinski fakultet, BeogradKlinika za vaskularnu i endovaskularnu hirurgiju, Klinički centar Srbije, Beograd + Medicinski fakultet, BeogradKlinika za vaskularnu i endovaskularnu hirurgiju, Klinički centar Srbije, Beograd + Medicinski fakultet, BeogradCentar za biohemiju, Klinički centar Srbije, BeogradKlinika za vaskularnu i endovaskularnu hirurgiju, Klinički centar Srbije, Beograd + Medicinski fakultet, BeogradKlinika za vaskularnu i endovaskularnu hirurgiju, Klinički centar Srbije, BeogradKlinika za vaskularnu i endovaskularnu hirurgiju, Klinički centar Srbije, Beograd + Medicinski fakultet, BeogradKlinika za vaskularnu i endovaskularnu hirurgiju, Klinički centar Srbije, Beograd + Medicinski fakultet, BeogradBackground The purpose of the present study is to evaluate if there is a specific relationship of the acute-phase proteins between patients with the chronic aortic occlusion (COA) and patients with diffuse aortoiliac occlusive disease (AIOD), and to investigate if there is a correlation between the acute phase proteins and the extent of disease. Methods Sixty patients with the aortoiliac occlusive disease were divided in two groups. First group consisted of thirty patients with the angiographic signs of diffuse aortoiliac occlusive disease, Leriche type III (AIOD group). Second (COA) group consisted of 30 patients characterized by either bifurcated aortic occlusion or juxtarenal aortic occlusion. Those two groups were compared according to symptomatology, ankle-brachial index (ABI) values, traditional risk factors and some acute phase proteins (high-sensitivity C-reactive protein - hs-CRP; homocysteine) taken at inclusion. Results The median serum hs-CRP was 4.85 mg/L and 15.7 mg/L in AIOD group and COA group, respectively. The difference was statistically significant (p=0.016). The mean plasma homocysteine was 21.44±11.25 mmol/L and 14.76±7.85 mmol/L in the AIOD group and COA group, respectively. Mean plasma homocysteine was significantly higher in patients with AIOD (p=0.005). Conclusions Our data demonstrate significant difference in hs-CRP and homocysteine concentrations among two variants of aortoiliac occlusive disease. In this particular pathology as COA, high hs-CRP concentration does not associate, at least with the angiographic extent of disease.http://scindeks-clanci.ceon.rs/data/pdf/2334-9492/2014/2334-94921401009I.pdfchronic aortic occlusionacute phase proteins |
| spellingShingle | Ilić Nikola S. Končar Igor B. Dragaš Marko V. Golubović Milka T. Marković Miroslav D. Sladojević Miloš M. Cvetković Slobodan D. Davidović Lazar B. A comparison of the acute phase proteins in chronic aortic occlusion versus diffuse aortoiliac occlusive disease Hospital Pharmacology chronic aortic occlusion acute phase proteins |
| title | A comparison of the acute phase proteins in chronic aortic occlusion versus diffuse aortoiliac occlusive disease |
| title_full | A comparison of the acute phase proteins in chronic aortic occlusion versus diffuse aortoiliac occlusive disease |
| title_fullStr | A comparison of the acute phase proteins in chronic aortic occlusion versus diffuse aortoiliac occlusive disease |
| title_full_unstemmed | A comparison of the acute phase proteins in chronic aortic occlusion versus diffuse aortoiliac occlusive disease |
| title_short | A comparison of the acute phase proteins in chronic aortic occlusion versus diffuse aortoiliac occlusive disease |
| title_sort | comparison of the acute phase proteins in chronic aortic occlusion versus diffuse aortoiliac occlusive disease |
| topic | chronic aortic occlusion acute phase proteins |
| url | http://scindeks-clanci.ceon.rs/data/pdf/2334-9492/2014/2334-94921401009I.pdf |
| work_keys_str_mv | AT ilicnikolas acomparisonoftheacutephaseproteinsinchronicaorticocclusionversusdiffuseaortoiliacocclusivedisease AT koncarigorb acomparisonoftheacutephaseproteinsinchronicaorticocclusionversusdiffuseaortoiliacocclusivedisease AT dragasmarkov acomparisonoftheacutephaseproteinsinchronicaorticocclusionversusdiffuseaortoiliacocclusivedisease AT golubovicmilkat acomparisonoftheacutephaseproteinsinchronicaorticocclusionversusdiffuseaortoiliacocclusivedisease AT markovicmiroslavd acomparisonoftheacutephaseproteinsinchronicaorticocclusionversusdiffuseaortoiliacocclusivedisease AT sladojevicmilosm acomparisonoftheacutephaseproteinsinchronicaorticocclusionversusdiffuseaortoiliacocclusivedisease AT cvetkovicslobodand acomparisonoftheacutephaseproteinsinchronicaorticocclusionversusdiffuseaortoiliacocclusivedisease AT davidoviclazarb acomparisonoftheacutephaseproteinsinchronicaorticocclusionversusdiffuseaortoiliacocclusivedisease AT ilicnikolas comparisonoftheacutephaseproteinsinchronicaorticocclusionversusdiffuseaortoiliacocclusivedisease AT koncarigorb comparisonoftheacutephaseproteinsinchronicaorticocclusionversusdiffuseaortoiliacocclusivedisease AT dragasmarkov comparisonoftheacutephaseproteinsinchronicaorticocclusionversusdiffuseaortoiliacocclusivedisease AT golubovicmilkat comparisonoftheacutephaseproteinsinchronicaorticocclusionversusdiffuseaortoiliacocclusivedisease AT markovicmiroslavd comparisonoftheacutephaseproteinsinchronicaorticocclusionversusdiffuseaortoiliacocclusivedisease AT sladojevicmilosm comparisonoftheacutephaseproteinsinchronicaorticocclusionversusdiffuseaortoiliacocclusivedisease AT cvetkovicslobodand comparisonoftheacutephaseproteinsinchronicaorticocclusionversusdiffuseaortoiliacocclusivedisease AT davidoviclazarb comparisonoftheacutephaseproteinsinchronicaorticocclusionversusdiffuseaortoiliacocclusivedisease |