Helicobacter pylori Infection in Multiple Sclerosis Patients
Background and Objective: Multiple sclerosis (MS) is an autoimmune disease that targets the central nervous system. Various studies have shown that several factors influence this disease’s occurrence and prevent its progress. Multiple studies have shown that several factors affect this disease’s occ...
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| Format: | Article |
| Language: | fas |
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Golestan University of Medical Sciences
2023-07-01
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| Series: | مجله دانشگاه علوم پزشکی گرگان |
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| Online Access: | http://goums.ac.ir/journal/article-1-4253-en.pdf |
| _version_ | 1827856883676872704 |
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| author | Negar Asgari Mohamad Hasan Naeimi Alireza Tahamtan Samin Zamani |
| author_facet | Negar Asgari Mohamad Hasan Naeimi Alireza Tahamtan Samin Zamani |
| author_sort | Negar Asgari |
| collection | DOAJ |
| description | Background and Objective: Multiple sclerosis (MS) is an autoimmune disease that targets the central nervous system. Various studies have shown that several factors influence this disease’s occurrence and prevent its progress. Multiple studies have shown that several factors affect this disease’s occurrence and prevent its progress. Helicobacter pylori can be mentioned among these factors. This study was conducted to determine Helicobacter pylori infection in MS patients and healthy individuals.
Methods: This case-control study was conducted on 100 patients with MS (mean age: 36.99±9.87 years) and 100 healthy subjects (mean age: 38.05±11.38 years) in Golestan province, north of Iran during 2021. The case group included eighty relapsing-remitting cases and twenty secondary progressive cases. Blood samples were taken from both groups, and after separating the serum using the ELISA test, anti-Helicobacter pylori antibody (IgG) was detected by determining the antibody titer.
Results: Helicobacter pylori IgG in the MS and control groups was 21% and 44%, respectively (P<0.05). The mean concentration of IgG in the case group was significantly lower than the control group (13.48±10.83 versus 19.78±16.14 AU/ml). The percentage of positive cases of IgG antibody against Helicobacter pylori in the relapsing-remitting and secondary progressive group of patients with MS was determined as 21.2% and 20%, respectively, and the difference between these two groups was not statistically significant.
Conclusion: The history of Helicobacter pylori infection is less than two times in patients with MS compared to healthy people probably indicate the protective role of this bacterium against this disease. |
| first_indexed | 2024-03-12T12:32:25Z |
| format | Article |
| id | doaj.art-fc3743c48c474b8785d08e4ff822e93c |
| institution | Directory Open Access Journal |
| issn | 1562-4765 2008-4080 |
| language | fas |
| last_indexed | 2024-03-12T12:32:25Z |
| publishDate | 2023-07-01 |
| publisher | Golestan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشگاه علوم پزشکی گرگان |
| spelling | doaj.art-fc3743c48c474b8785d08e4ff822e93c2023-08-29T08:21:54ZfasGolestan University of Medical Sciencesمجله دانشگاه علوم پزشکی گرگان1562-47652008-40802023-07-012523844Helicobacter pylori Infection in Multiple Sclerosis PatientsNegar Asgari0Mohamad Hasan Naeimi1Alireza Tahamtan2Samin Zamani3 M.Sc student of Medical Microbiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran. Assistant Professor, Department of Neurology, Sayyad Shirazi Hospital, Golestan University of Medical Sciences, Gorgan, Iran. Assistant Professor, Department of Microbiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran. Assistant Professor, Department of Microbiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran and Assistant Professor, Infectious Disease Research Center, Golestan University of Medical Sciences, Gorgan, Iran. Background and Objective: Multiple sclerosis (MS) is an autoimmune disease that targets the central nervous system. Various studies have shown that several factors influence this disease’s occurrence and prevent its progress. Multiple studies have shown that several factors affect this disease’s occurrence and prevent its progress. Helicobacter pylori can be mentioned among these factors. This study was conducted to determine Helicobacter pylori infection in MS patients and healthy individuals. Methods: This case-control study was conducted on 100 patients with MS (mean age: 36.99±9.87 years) and 100 healthy subjects (mean age: 38.05±11.38 years) in Golestan province, north of Iran during 2021. The case group included eighty relapsing-remitting cases and twenty secondary progressive cases. Blood samples were taken from both groups, and after separating the serum using the ELISA test, anti-Helicobacter pylori antibody (IgG) was detected by determining the antibody titer. Results: Helicobacter pylori IgG in the MS and control groups was 21% and 44%, respectively (P<0.05). The mean concentration of IgG in the case group was significantly lower than the control group (13.48±10.83 versus 19.78±16.14 AU/ml). The percentage of positive cases of IgG antibody against Helicobacter pylori in the relapsing-remitting and secondary progressive group of patients with MS was determined as 21.2% and 20%, respectively, and the difference between these two groups was not statistically significant. Conclusion: The history of Helicobacter pylori infection is less than two times in patients with MS compared to healthy people probably indicate the protective role of this bacterium against this disease.http://goums.ac.ir/journal/article-1-4253-en.pdfmultiple sclerosishelicobacter pyloriimmunoglobulin g |
| spellingShingle | Negar Asgari Mohamad Hasan Naeimi Alireza Tahamtan Samin Zamani Helicobacter pylori Infection in Multiple Sclerosis Patients مجله دانشگاه علوم پزشکی گرگان multiple sclerosis helicobacter pylori immunoglobulin g |
| title | Helicobacter pylori Infection in Multiple Sclerosis Patients |
| title_full | Helicobacter pylori Infection in Multiple Sclerosis Patients |
| title_fullStr | Helicobacter pylori Infection in Multiple Sclerosis Patients |
| title_full_unstemmed | Helicobacter pylori Infection in Multiple Sclerosis Patients |
| title_short | Helicobacter pylori Infection in Multiple Sclerosis Patients |
| title_sort | helicobacter pylori infection in multiple sclerosis patients |
| topic | multiple sclerosis helicobacter pylori immunoglobulin g |
| url | http://goums.ac.ir/journal/article-1-4253-en.pdf |
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