Functional Analysis of Two Divergent C4 Isotypes in the Classical and Lectin Pathways of Complement Activation in the Common Carp (<i>Cyprinus carpio</i>)

Functional Analysis of Two Divergent C4 Isotypes in the Classical and Lectin Pathways of Complement Activation in the Common Carp (<i>Cyprinus carpio</i>)

In the evolution of the complement system, a major humoral innate immune factor, the existence of multiple isotypes of the complement components is considered as a key strategy to enhance innate immune defense. Complement C4 is also diversified in a wide range of vertebrate species including teleost...

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Bibliographic Details
Main Authors: Rosli Nehlah, Akira Yamamoto, Takahiro Nagasawa, Tomonori Somamoto, Miki Nakao
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Journal of Marine Science and Engineering
Subjects:
complement system
classical pathway
lectin pathway
C4
teleost
carp
Online Access:https://www.mdpi.com/2077-1312/11/4/707

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