Lipofuscin: formation, effects and role of macroautophagy
Oxidative stress plays a crucial role in the development of the aging process and age dependent diseases. Both are closely connected to disturbances of proteostasis by protein oxidation and an impairment of the proteasomal system. The final consequence is the accumulation of highly cross-linked unde...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2013-01-01
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| Series: | Redox Biology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221323171300027X |
| _version_ | 1819034572146343936 |
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| author | Annika Höhn Tilman Grune |
| author_facet | Annika Höhn Tilman Grune |
| author_sort | Annika Höhn |
| collection | DOAJ |
| description | Oxidative stress plays a crucial role in the development of the aging process and age dependent diseases. Both are closely connected to disturbances of proteostasis by protein oxidation and an impairment of the proteasomal system. The final consequence is the accumulation of highly cross-linked undegradable aggregates such as lipofuscin. These aggregates of damaged proteins are detrimental to normal cell functions. Here we provide an overview about effect of these aggregates on the proteasomal system, followed by transcription factor activation and loss of cell viability. Furthermore, findings on the mechanism of radical genesis, proteasomal inhibition and the required components of lipofuscin formation were resumed. |
| first_indexed | 2024-12-21T07:35:52Z |
| format | Article |
| id | doaj.art-fc383f0d4e304868912000871879b83a |
| institution | Directory Open Access Journal |
| issn | 2213-2317 |
| language | English |
| last_indexed | 2024-12-21T07:35:52Z |
| publishDate | 2013-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Redox Biology |
| spelling | doaj.art-fc383f0d4e304868912000871879b83a2022-12-21T19:11:27ZengElsevierRedox Biology2213-23172013-01-011114014410.1016/j.redox.2013.01.006Lipofuscin: formation, effects and role of macroautophagyAnnika HöhnTilman GruneOxidative stress plays a crucial role in the development of the aging process and age dependent diseases. Both are closely connected to disturbances of proteostasis by protein oxidation and an impairment of the proteasomal system. The final consequence is the accumulation of highly cross-linked undegradable aggregates such as lipofuscin. These aggregates of damaged proteins are detrimental to normal cell functions. Here we provide an overview about effect of these aggregates on the proteasomal system, followed by transcription factor activation and loss of cell viability. Furthermore, findings on the mechanism of radical genesis, proteasomal inhibition and the required components of lipofuscin formation were resumed.http://www.sciencedirect.com/science/article/pii/S221323171300027XAgingOxidative stressProteasomeLipofuscinAutophagy |
| spellingShingle | Annika Höhn Tilman Grune Lipofuscin: formation, effects and role of macroautophagy Redox Biology Aging Oxidative stress Proteasome Lipofuscin Autophagy |
| title | Lipofuscin: formation, effects and role of macroautophagy |
| title_full | Lipofuscin: formation, effects and role of macroautophagy |
| title_fullStr | Lipofuscin: formation, effects and role of macroautophagy |
| title_full_unstemmed | Lipofuscin: formation, effects and role of macroautophagy |
| title_short | Lipofuscin: formation, effects and role of macroautophagy |
| title_sort | lipofuscin formation effects and role of macroautophagy |
| topic | Aging Oxidative stress Proteasome Lipofuscin Autophagy |
| url | http://www.sciencedirect.com/science/article/pii/S221323171300027X |
| work_keys_str_mv | AT annikahohn lipofuscinformationeffectsandroleofmacroautophagy AT tilmangrune lipofuscinformationeffectsandroleofmacroautophagy |