Visceral Adiposity and Risk of Stroke: A Mendelian Randomization Study
PurposeIn recent years, metabolic syndrome has risen in prevalence and brought a heavy disease burden to modern society. As the representative aspect of metabolic syndrome, obesity has been shown to be related to an increased risk of stroke. Given that visceral adipose tissue (VAT) forms the fundame...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.804851/full |
| _version_ | 1811271759061581824 |
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| author | Ran Xu Ran Xu Xinzhi Hu Tao Wang Tao Wang Yutong Yang Nan Jiang Nan Jiang Jichang Luo Jichang Luo Xiao Zhang Xiao Zhang Aman B. Patel Adam A. Dmytriw Adam A. Dmytriw Liqun Jiao Liqun Jiao Liqun Jiao |
| author_facet | Ran Xu Ran Xu Xinzhi Hu Tao Wang Tao Wang Yutong Yang Nan Jiang Nan Jiang Jichang Luo Jichang Luo Xiao Zhang Xiao Zhang Aman B. Patel Adam A. Dmytriw Adam A. Dmytriw Liqun Jiao Liqun Jiao Liqun Jiao |
| author_sort | Ran Xu |
| collection | DOAJ |
| description | PurposeIn recent years, metabolic syndrome has risen in prevalence and brought a heavy disease burden to modern society. As the representative aspect of metabolic syndrome, obesity has been shown to be related to an increased risk of stroke. Given that visceral adipose tissue (VAT) forms the fundamental basis of central obesity, we sought to explore a causal relationship between VAT and stroke by using mendelian randomization (MR) methods.MethodsBased on two large genome-wide association studies (GWAS) including 325,153 and 35,762 cases of VAT and stroke, respectively, we conducted a MR study which has the inherent advantage of reducing the noise of confounding and reverse causation.ResultsVAT had a significant causal association with ischemic stroke (OR, per 1kg increase in VAT mass, 1.30; 95% CI, 1.18 ~ 1.45; P = 5.87E-07) as opposed to intracranial hemorrhage (ICH) (OR, 1.15; 95% CI, 0.70 ~ 1.88, P = 5.81E-01) as evaluated with inverse-variance weighting (IVW). Regarding subtypes of ischemic stroke, there was a significant causal effect for cardioembolic stroke (OR, 1.34; 95% CI, 1.13 ~ 1.58, P = 8.07E-04), and potential causal effect for small-vessel stroke (OR, 1.32; 95% CI, 1.06 ~ 1.65, P = 1.39E-02) and large-artery atherosclerotic stroke (OR, 1.33; 95% CI, 1.03 ~ 1.70, P = 2.59E-02).ConclusionsThis study provides potential evidence for a causal role of VAT in ischemic stroke and could suggest novel genetical therapeutic strategies for distinct subtypes of ischemic stroke. |
| first_indexed | 2024-04-12T22:26:49Z |
| format | Article |
| id | doaj.art-fc3b92e2afc24d52b0b3a69462d81eb1 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-12T22:26:49Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj.art-fc3b92e2afc24d52b0b3a69462d81eb12022-12-22T03:14:08ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-04-011310.3389/fneur.2022.804851804851Visceral Adiposity and Risk of Stroke: A Mendelian Randomization StudyRan Xu0Ran Xu1Xinzhi Hu2Tao Wang3Tao Wang4Yutong Yang5Nan Jiang6Nan Jiang7Jichang Luo8Jichang Luo9Xiao Zhang10Xiao Zhang11Aman B. Patel12Adam A. Dmytriw13Adam A. Dmytriw14Liqun Jiao15Liqun Jiao16Liqun Jiao17Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, ChinaChina International Neuroscience Institute (China-INI), Beijing, ChinaDepartment of Human Anatomy, Histology and Embryology, Peking Union Medical College Hospital, Peking Union Medical College, Institute of Basic Medical Sciences, Chinese Academy of Medical Science, Beijing, ChinaDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, ChinaChina International Neuroscience Institute (China-INI), Beijing, ChinaFaculty of Medicine, Imperial College London, National Heart and Lung Institute, London, United KingdomDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, ChinaChina International Neuroscience Institute (China-INI), Beijing, ChinaDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, ChinaChina International Neuroscience Institute (China-INI), Beijing, ChinaDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, ChinaChina International Neuroscience Institute (China-INI), Beijing, ChinaNeuroendovascular Program, Massachusetts General Hospital, Boston, MA, United StatesNeuroendovascular Program, Massachusetts General Hospital, Boston, MA, United StatesNeuroradiology and Neurointervention Service, Brigham and Women's Hospital Harvard Medical School, Boston, MA, United StatesDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, ChinaChina International Neuroscience Institute (China-INI), Beijing, ChinaDepartment of Interventional Neuroradiology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaPurposeIn recent years, metabolic syndrome has risen in prevalence and brought a heavy disease burden to modern society. As the representative aspect of metabolic syndrome, obesity has been shown to be related to an increased risk of stroke. Given that visceral adipose tissue (VAT) forms the fundamental basis of central obesity, we sought to explore a causal relationship between VAT and stroke by using mendelian randomization (MR) methods.MethodsBased on two large genome-wide association studies (GWAS) including 325,153 and 35,762 cases of VAT and stroke, respectively, we conducted a MR study which has the inherent advantage of reducing the noise of confounding and reverse causation.ResultsVAT had a significant causal association with ischemic stroke (OR, per 1kg increase in VAT mass, 1.30; 95% CI, 1.18 ~ 1.45; P = 5.87E-07) as opposed to intracranial hemorrhage (ICH) (OR, 1.15; 95% CI, 0.70 ~ 1.88, P = 5.81E-01) as evaluated with inverse-variance weighting (IVW). Regarding subtypes of ischemic stroke, there was a significant causal effect for cardioembolic stroke (OR, 1.34; 95% CI, 1.13 ~ 1.58, P = 8.07E-04), and potential causal effect for small-vessel stroke (OR, 1.32; 95% CI, 1.06 ~ 1.65, P = 1.39E-02) and large-artery atherosclerotic stroke (OR, 1.33; 95% CI, 1.03 ~ 1.70, P = 2.59E-02).ConclusionsThis study provides potential evidence for a causal role of VAT in ischemic stroke and could suggest novel genetical therapeutic strategies for distinct subtypes of ischemic stroke.https://www.frontiersin.org/articles/10.3389/fneur.2022.804851/fullvisceral adipose tissue (VAT)ischemic strokeintracranial hemorrhage (ICH)mendelian randomization (MR)single nucleotide polymorphism (SNP) |
| spellingShingle | Ran Xu Ran Xu Xinzhi Hu Tao Wang Tao Wang Yutong Yang Nan Jiang Nan Jiang Jichang Luo Jichang Luo Xiao Zhang Xiao Zhang Aman B. Patel Adam A. Dmytriw Adam A. Dmytriw Liqun Jiao Liqun Jiao Liqun Jiao Visceral Adiposity and Risk of Stroke: A Mendelian Randomization Study Frontiers in Neurology visceral adipose tissue (VAT) ischemic stroke intracranial hemorrhage (ICH) mendelian randomization (MR) single nucleotide polymorphism (SNP) |
| title | Visceral Adiposity and Risk of Stroke: A Mendelian Randomization Study |
| title_full | Visceral Adiposity and Risk of Stroke: A Mendelian Randomization Study |
| title_fullStr | Visceral Adiposity and Risk of Stroke: A Mendelian Randomization Study |
| title_full_unstemmed | Visceral Adiposity and Risk of Stroke: A Mendelian Randomization Study |
| title_short | Visceral Adiposity and Risk of Stroke: A Mendelian Randomization Study |
| title_sort | visceral adiposity and risk of stroke a mendelian randomization study |
| topic | visceral adipose tissue (VAT) ischemic stroke intracranial hemorrhage (ICH) mendelian randomization (MR) single nucleotide polymorphism (SNP) |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.804851/full |
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