Effect of Maternal Docosahexaenoic Acid (DHA) Supplementation on Offspring Neurodevelopment at 12 Months in India: A Randomized Controlled Trial
Intake of dietary docosahexaenoic acid (DHA 22:6n-3) is very low among Indian pregnant women. Maternal supplementation during pregnancy and lactation may benefit offspring neurodevelopment. We conducted a double-blind, randomized, placebo-controlled trial to test the effectiveness of supplementing p...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-10-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/12/10/3041 |
| _version_ | 1797551877232001024 |
|---|---|
| author | Shweta Khandelwal Dimple Kondal Monica Chaudhry Kamal Patil Mallaiah Kenchaveeraiah Swamy Deepa Metgud Sandesh Jogalekar Mahesh Kamate Gauri Divan Ruby Gupta Dorairaj Prabhakaran Nikhil Tandon Usha Ramakrishnan Aryeh D. Stein |
| author_facet | Shweta Khandelwal Dimple Kondal Monica Chaudhry Kamal Patil Mallaiah Kenchaveeraiah Swamy Deepa Metgud Sandesh Jogalekar Mahesh Kamate Gauri Divan Ruby Gupta Dorairaj Prabhakaran Nikhil Tandon Usha Ramakrishnan Aryeh D. Stein |
| author_sort | Shweta Khandelwal |
| collection | DOAJ |
| description | Intake of dietary docosahexaenoic acid (DHA 22:6n-3) is very low among Indian pregnant women. Maternal supplementation during pregnancy and lactation may benefit offspring neurodevelopment. We conducted a double-blind, randomized, placebo-controlled trial to test the effectiveness of supplementing pregnant Indian women (singleton gestation) from ≤20 weeks through 6 months postpartum with 400 mg/d algal DHA compared to placebo on neurodevelopment of their offspring at 12 months. Of 3379 women screened, 1131 were found eligible; 957 were randomized. The primary outcome was infant neurodevelopment at 12 months, assessed using the Development Assessment Scale for Indian Infants (DASII). Both groups were well balanced on sociodemographic variables at baseline. More than 72% of women took >90% of their assigned treatment. Twenty-five serious adverse events (SAEs), none related to the intervention, (DHA group = 16; placebo = 9) were noted. Of 902 live births, 878 were followed up to 12 months; the DASII was administered to 863 infants. At 12 months, the mean development quotient (DQ) scores in the DHA and placebo groups were not statistically significant (96.6 ± 12.2 vs. 97.1 ± 13.0, <i>p</i> = 0.60). Supplementing mothers through pregnancy and lactation with 400 mg/d DHA did not impact offspring neurodevelopment at 12 months of age in this setting. |
| first_indexed | 2024-03-10T15:51:21Z |
| format | Article |
| id | doaj.art-fc3ccf0b634d401296b17440f132fa70 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T15:51:21Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-fc3ccf0b634d401296b17440f132fa702023-11-20T16:02:02ZengMDPI AGNutrients2072-66432020-10-011210304110.3390/nu12103041Effect of Maternal Docosahexaenoic Acid (DHA) Supplementation on Offspring Neurodevelopment at 12 Months in India: A Randomized Controlled TrialShweta Khandelwal0Dimple Kondal1Monica Chaudhry2Kamal Patil3Mallaiah Kenchaveeraiah Swamy4Deepa Metgud5Sandesh Jogalekar6Mahesh Kamate7Gauri Divan8Ruby Gupta9Dorairaj Prabhakaran10Nikhil Tandon11Usha Ramakrishnan12Aryeh D. Stein13Public Health Foundation of India, 47, Sector 44, Institutional area, Gurugram, Haryana 122003, IndiaPublic Health Foundation of India, 47, Sector 44, Institutional area, Gurugram, Haryana 122003, IndiaPublic Health Foundation of India, 47, Sector 44, Institutional area, Gurugram, Haryana 122003, IndiaKAHER’s JN Medical College, JNMC KLE University Campus, Nehru Nagar, Belgaum, Karnataka 590010, IndiaKAHER’s JN Medical College, JNMC KLE University Campus, Nehru Nagar, Belgaum, Karnataka 590010, IndiaKAHER’s Institute of Physiotherapy, JNMC KLE University Campus, Nehru Nagar, Belgaum, Karnataka 590010, IndiaKAHER’s JN Medical College, JNMC KLE University Campus, Nehru Nagar, Belgaum, Karnataka 590010, IndiaKAHER’s JN Medical College, JNMC KLE University Campus, Nehru Nagar, Belgaum, Karnataka 590010, IndiaSangath, C-1/52, Block C 1, Bhim Nagri, Hauz Khas, New Delhi 110016, IndiaPublic Health Foundation of India, 47, Sector 44, Institutional area, Gurugram, Haryana 122003, IndiaPublic Health Foundation of India, 47, Sector 44, Institutional area, Gurugram, Haryana 122003, IndiaAll India Institute of Medical Sciences, Sri Aurobindo Marg, New Delhi 110029, IndiaHubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USAHubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USAIntake of dietary docosahexaenoic acid (DHA 22:6n-3) is very low among Indian pregnant women. Maternal supplementation during pregnancy and lactation may benefit offspring neurodevelopment. We conducted a double-blind, randomized, placebo-controlled trial to test the effectiveness of supplementing pregnant Indian women (singleton gestation) from ≤20 weeks through 6 months postpartum with 400 mg/d algal DHA compared to placebo on neurodevelopment of their offspring at 12 months. Of 3379 women screened, 1131 were found eligible; 957 were randomized. The primary outcome was infant neurodevelopment at 12 months, assessed using the Development Assessment Scale for Indian Infants (DASII). Both groups were well balanced on sociodemographic variables at baseline. More than 72% of women took >90% of their assigned treatment. Twenty-five serious adverse events (SAEs), none related to the intervention, (DHA group = 16; placebo = 9) were noted. Of 902 live births, 878 were followed up to 12 months; the DASII was administered to 863 infants. At 12 months, the mean development quotient (DQ) scores in the DHA and placebo groups were not statistically significant (96.6 ± 12.2 vs. 97.1 ± 13.0, <i>p</i> = 0.60). Supplementing mothers through pregnancy and lactation with 400 mg/d DHA did not impact offspring neurodevelopment at 12 months of age in this setting.https://www.mdpi.com/2072-6643/12/10/3041maternal supplementationpregnancylactationdocosahexaenoic acid (DHA)neurodevelopmentrandomized controlled trial (RCT) |
| spellingShingle | Shweta Khandelwal Dimple Kondal Monica Chaudhry Kamal Patil Mallaiah Kenchaveeraiah Swamy Deepa Metgud Sandesh Jogalekar Mahesh Kamate Gauri Divan Ruby Gupta Dorairaj Prabhakaran Nikhil Tandon Usha Ramakrishnan Aryeh D. Stein Effect of Maternal Docosahexaenoic Acid (DHA) Supplementation on Offspring Neurodevelopment at 12 Months in India: A Randomized Controlled Trial Nutrients maternal supplementation pregnancy lactation docosahexaenoic acid (DHA) neurodevelopment randomized controlled trial (RCT) |
| title | Effect of Maternal Docosahexaenoic Acid (DHA) Supplementation on Offspring Neurodevelopment at 12 Months in India: A Randomized Controlled Trial |
| title_full | Effect of Maternal Docosahexaenoic Acid (DHA) Supplementation on Offspring Neurodevelopment at 12 Months in India: A Randomized Controlled Trial |
| title_fullStr | Effect of Maternal Docosahexaenoic Acid (DHA) Supplementation on Offspring Neurodevelopment at 12 Months in India: A Randomized Controlled Trial |
| title_full_unstemmed | Effect of Maternal Docosahexaenoic Acid (DHA) Supplementation on Offspring Neurodevelopment at 12 Months in India: A Randomized Controlled Trial |
| title_short | Effect of Maternal Docosahexaenoic Acid (DHA) Supplementation on Offspring Neurodevelopment at 12 Months in India: A Randomized Controlled Trial |
| title_sort | effect of maternal docosahexaenoic acid dha supplementation on offspring neurodevelopment at 12 months in india a randomized controlled trial |
| topic | maternal supplementation pregnancy lactation docosahexaenoic acid (DHA) neurodevelopment randomized controlled trial (RCT) |
| url | https://www.mdpi.com/2072-6643/12/10/3041 |
| work_keys_str_mv | AT shwetakhandelwal effectofmaternaldocosahexaenoicaciddhasupplementationonoffspringneurodevelopmentat12monthsinindiaarandomizedcontrolledtrial AT dimplekondal effectofmaternaldocosahexaenoicaciddhasupplementationonoffspringneurodevelopmentat12monthsinindiaarandomizedcontrolledtrial AT monicachaudhry effectofmaternaldocosahexaenoicaciddhasupplementationonoffspringneurodevelopmentat12monthsinindiaarandomizedcontrolledtrial AT kamalpatil effectofmaternaldocosahexaenoicaciddhasupplementationonoffspringneurodevelopmentat12monthsinindiaarandomizedcontrolledtrial AT mallaiahkenchaveeraiahswamy effectofmaternaldocosahexaenoicaciddhasupplementationonoffspringneurodevelopmentat12monthsinindiaarandomizedcontrolledtrial AT deepametgud effectofmaternaldocosahexaenoicaciddhasupplementationonoffspringneurodevelopmentat12monthsinindiaarandomizedcontrolledtrial AT sandeshjogalekar effectofmaternaldocosahexaenoicaciddhasupplementationonoffspringneurodevelopmentat12monthsinindiaarandomizedcontrolledtrial AT maheshkamate effectofmaternaldocosahexaenoicaciddhasupplementationonoffspringneurodevelopmentat12monthsinindiaarandomizedcontrolledtrial AT gauridivan effectofmaternaldocosahexaenoicaciddhasupplementationonoffspringneurodevelopmentat12monthsinindiaarandomizedcontrolledtrial AT rubygupta effectofmaternaldocosahexaenoicaciddhasupplementationonoffspringneurodevelopmentat12monthsinindiaarandomizedcontrolledtrial AT dorairajprabhakaran effectofmaternaldocosahexaenoicaciddhasupplementationonoffspringneurodevelopmentat12monthsinindiaarandomizedcontrolledtrial AT nikhiltandon effectofmaternaldocosahexaenoicaciddhasupplementationonoffspringneurodevelopmentat12monthsinindiaarandomizedcontrolledtrial AT usharamakrishnan effectofmaternaldocosahexaenoicaciddhasupplementationonoffspringneurodevelopmentat12monthsinindiaarandomizedcontrolledtrial AT aryehdstein effectofmaternaldocosahexaenoicaciddhasupplementationonoffspringneurodevelopmentat12monthsinindiaarandomizedcontrolledtrial |