Recombinant HIV envelope proteins fail to engage germline versions of anti-CD4bs bNAbs.

Recombinant HIV envelope proteins fail to engage germline versions of anti-CD4bs bNAbs.

Vaccine candidates for HIV-1 so far have not been able to elicit broadly neutralizing antibodies (bNAbs) although they express the epitopes recognized by bNAbs to the HIV envelope glycoprotein (Env). To understand whether and how Env immunogens interact with the predicted germline versions of known...

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Bibliographic Details
Main Authors: Sam Hoot, Andrew T McGuire, Kristen W Cohen, Roland K Strong, Lars Hangartner, Florian Klein, Ron Diskin, Johannes F Scheid, D Noah Sather, Dennis R Burton, Leonidas Stamatatos
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3536657?pdf=render

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