Spatial transcriptomic brain imaging reveals the effects of immunomodulation therapy on specific regional brain cells in a mouse dementia model

Abstract Increasing evidence of brain-immune crosstalk raises expectations for the efficacy of novel immunotherapies in Alzheimer’s disease (AD), but the lack of methods to examine brain tissues makes it difficult to evaluate therapeutics. Here, we investigated the changes in spatial transcriptomic...

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Autors principals: Eun Ji Lee, Minseok Suh, Hongyoon Choi, Yoori Choi, Do Won Hwang, Sungwoo Bae, Dong Soo Lee
Format: Article
Idioma:English
Publicat: BMC 2024-05-01
Col·lecció:BMC Genomics
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Accés en línia:https://doi.org/10.1186/s12864-024-10434-8