Spatial transcriptomic brain imaging reveals the effects of immunomodulation therapy on specific regional brain cells in a mouse dementia model

Spatial transcriptomic brain imaging reveals the effects of immunomodulation therapy on specific regional brain cells in a mouse dementia model

Abstract Increasing evidence of brain-immune crosstalk raises expectations for the efficacy of novel immunotherapies in Alzheimer’s disease (AD), but the lack of methods to examine brain tissues makes it difficult to evaluate therapeutics. Here, we investigated the changes in spatial transcriptomic...

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Bibliografiske detaljer
Main Authors: Eun Ji Lee, Minseok Suh, Hongyoon Choi, Yoori Choi, Do Won Hwang, Sungwoo Bae, Dong Soo Lee
Format: Article
Sprog:English
Udgivet: BMC 2024-05-01
Serier:BMC Genomics
Fag:
Spatial transcriptomics
Brain imaging
Cell type decomposition
Cell state annotation
Major brain cells
Rare immune cells
Online adgang:https://doi.org/10.1186/s12864-024-10434-8

Internet

https://doi.org/10.1186/s12864-024-10434-8

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