ATF4 Contributes to Ovulation via Regulating COX2/PGE2 Expression: A Potential Role of ATF4 in PCOS

ATF4 Contributes to Ovulation via Regulating COX2/PGE2 Expression: A Potential Role of ATF4 in PCOS

Ovulatory disorder is common in patients with hyperprolactinemia or polycystic ovary syndrome (PCOS). Previous studies have shown that ATF4 plays critical role in apoptosis and glucose homeostasis, but its role in regulating reproductive function was not explored. The present study investigated the...

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Bibliographic Details
Main Authors: Fangfang Di, Jiansheng Liu, Shang Li, Guangxin Yao, Yan Hong, Zi-Jiang Chen, Weiping Li, Yanzhi Du
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Endocrinology
Subjects:
ATF4
ovulation
human granulosa cells
COX2
polycystic ovary syndrome
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00669/full

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