Treatment with IL-7 prevents the decline of circulating CD4+ T cells during the acute phase of SIV infection in rhesus macaques.

Treatment with IL-7 prevents the decline of circulating CD4+ T cells during the acute phase of SIV infection in rhesus macaques.

Although treatment with interleukin-7 (IL-7) was shown to transiently expand the naïve and memory T-cell pools in patients with chronic HIV-1 infection receiving antiretroviral therapy (ART), it is uncertain whether a full immunologic reconstitution can be achieved. Moreover, the effects of IL-7 hav...

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Main Authors: Lia Vassena, Huiyi Miao, Raffaello Cimbro, Mauro S Malnati, Giulia Cassina, Michael A Proschan, Vanessa M Hirsch, Bernard A Lafont, Michel Morre, Anthony S Fauci, Paolo Lusso
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3325214?pdf=render

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