Clinicopathological features and prognosis of TFE3-positive renal cell carcinoma
BackgroundThis study aimed to investigate the expression profile of TFE3 in renal cell carcinoma (RCC) and the clinicopathological features as well as prognosis of TFE3-positive RCC.MethodsTissue sections from 796 patients with RCC were collected for immunohistochemical staining of TFE3. Molecular T...
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| Format: | Article |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1017425/full |
| _version_ | 1811229331753533440 |
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| author | Xiang Dong Yuxin Chen Jun Pan Wenliang Ma Peng Zhou Ming Chen Hongqian Guo Weidong Gan |
| author_facet | Xiang Dong Yuxin Chen Jun Pan Wenliang Ma Peng Zhou Ming Chen Hongqian Guo Weidong Gan |
| author_sort | Xiang Dong |
| collection | DOAJ |
| description | BackgroundThis study aimed to investigate the expression profile of TFE3 in renal cell carcinoma (RCC) and the clinicopathological features as well as prognosis of TFE3-positive RCC.MethodsTissue sections from 796 patients with RCC were collected for immunohistochemical staining of TFE3. Molecular TFE3 rearrangement tests were also carried out on the TFE3-positive RCCs using fluorescence in situ hybridization and RNA-sequencing assays. Both clinicopathological features and follow-up information were collected for further analysis.ResultsThe present study showed that 91 patients with RCC (91/796, 11.4%) were TFE3 positive expression but only 31 (31/91, 34.1%) of the patients were diagnosed with Xp11.2 translocation RCC. Further, it was found that the patients with TFE3-positive RCCs were more likely to develop lymph node and distant metastasis at diagnosis as well as presented a significantly higher WHO/ISUP nuclear grade and AJCC stage as compared with patients with TFE3-negative RCCs (p<0.01). Results of univariate and multivariate analyses showed that TFE3 positive expression was an independent prognostic factor associated with poor progression-free survival. Further, the findings of survival analysis showed that patients with positive TFE3 expression showed a shorter progression-free survival as compared with the patients with negative expression of TFE3 (p<0.001). In addition, results of the survival analysis found that there was no significant difference in progression-free survival between the Xp11.2 translocation RCC and TFE3-positive non-Xp11.2 translocation RCC groups (p=0.9607).ConclusionThis study found that nuclear TFE3 expression is not specific to the Xp11.2 translocation RCC. Moreover, the positive TFE3 expression is associated with tumor progression and poor prognosis in patients with RCC irrespective of the presence of TFE3 translocation. |
| first_indexed | 2024-04-12T10:14:11Z |
| format | Article |
| id | doaj.art-fc420b0823a0487d981bbf39b7aae988 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T10:14:11Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-fc420b0823a0487d981bbf39b7aae9882022-12-22T03:37:15ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-10-011210.3389/fonc.2022.10174251017425Clinicopathological features and prognosis of TFE3-positive renal cell carcinomaXiang Dong0Yuxin Chen1Jun Pan2Wenliang Ma3Peng Zhou4Ming Chen5Hongqian Guo6Weidong Gan7Department of Urology, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Urology, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Urology, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Urology, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Urology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, ChinaDepartment of Pathology, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Urology, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Urology, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, ChinaBackgroundThis study aimed to investigate the expression profile of TFE3 in renal cell carcinoma (RCC) and the clinicopathological features as well as prognosis of TFE3-positive RCC.MethodsTissue sections from 796 patients with RCC were collected for immunohistochemical staining of TFE3. Molecular TFE3 rearrangement tests were also carried out on the TFE3-positive RCCs using fluorescence in situ hybridization and RNA-sequencing assays. Both clinicopathological features and follow-up information were collected for further analysis.ResultsThe present study showed that 91 patients with RCC (91/796, 11.4%) were TFE3 positive expression but only 31 (31/91, 34.1%) of the patients were diagnosed with Xp11.2 translocation RCC. Further, it was found that the patients with TFE3-positive RCCs were more likely to develop lymph node and distant metastasis at diagnosis as well as presented a significantly higher WHO/ISUP nuclear grade and AJCC stage as compared with patients with TFE3-negative RCCs (p<0.01). Results of univariate and multivariate analyses showed that TFE3 positive expression was an independent prognostic factor associated with poor progression-free survival. Further, the findings of survival analysis showed that patients with positive TFE3 expression showed a shorter progression-free survival as compared with the patients with negative expression of TFE3 (p<0.001). In addition, results of the survival analysis found that there was no significant difference in progression-free survival between the Xp11.2 translocation RCC and TFE3-positive non-Xp11.2 translocation RCC groups (p=0.9607).ConclusionThis study found that nuclear TFE3 expression is not specific to the Xp11.2 translocation RCC. Moreover, the positive TFE3 expression is associated with tumor progression and poor prognosis in patients with RCC irrespective of the presence of TFE3 translocation.https://www.frontiersin.org/articles/10.3389/fonc.2022.1017425/fullTFE3Xp11.2 translocationRCC (Renal Cell Carcinoma)Clinico pathologic characteristicsprognosis |
| spellingShingle | Xiang Dong Yuxin Chen Jun Pan Wenliang Ma Peng Zhou Ming Chen Hongqian Guo Weidong Gan Clinicopathological features and prognosis of TFE3-positive renal cell carcinoma Frontiers in Oncology TFE3 Xp11.2 translocation RCC (Renal Cell Carcinoma) Clinico pathologic characteristics prognosis |
| title | Clinicopathological features and prognosis of TFE3-positive renal cell carcinoma |
| title_full | Clinicopathological features and prognosis of TFE3-positive renal cell carcinoma |
| title_fullStr | Clinicopathological features and prognosis of TFE3-positive renal cell carcinoma |
| title_full_unstemmed | Clinicopathological features and prognosis of TFE3-positive renal cell carcinoma |
| title_short | Clinicopathological features and prognosis of TFE3-positive renal cell carcinoma |
| title_sort | clinicopathological features and prognosis of tfe3 positive renal cell carcinoma |
| topic | TFE3 Xp11.2 translocation RCC (Renal Cell Carcinoma) Clinico pathologic characteristics prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1017425/full |
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