Association between serum NLRP3 and malignant brain edema in patients with acute ischemic stroke
Abstract Background We aimed to explore the association of serum level of the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) and its related inflammatory biomarkers (hypoxia inducible factor-1α, cathepsin B, caspase-1 and matrix metalloproteinase-9)...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-09-01
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| Series: | BMC Neurology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12883-021-02369-4 |
| _version_ | 1818361612133728256 |
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| author | Yanan Wang Hexiao Huang Weihong He Shihong Zhang Ming Liu Simiao Wu |
| author_facet | Yanan Wang Hexiao Huang Weihong He Shihong Zhang Ming Liu Simiao Wu |
| author_sort | Yanan Wang |
| collection | DOAJ |
| description | Abstract Background We aimed to explore the association of serum level of the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) and its related inflammatory biomarkers (hypoxia inducible factor-1α, cathepsin B, caspase-1 and matrix metalloproteinase-9) with malignant brain edema (MBE) in patients with acute ischemic stroke. Methods We prospectively enrolled patients with acute ischemic stroke admitted < 24 h from onset of symptoms. Brain CT was performed on admission and blood samples were collected. Repeated brain CT/MRI was performed < 7 days of admission to identify the presence of MBE, defined as neurological deterioration with imaging signs of midline shift or compressed basal cisterns. Logistic regression analysis was performed to assess the association between inflammatory biomarkers and MBE, adjusted for age and National Institutes of Health Stroke Scale (NIHSS). Results 200 patients (69.3 ± 14.3 years; male 55 %) were included for analysis, of whom 26 patients developed MBE (median time from stroke onset to MBE 32.5 h). Compared with patients without MBE, those with MBE had higher level of serum concentration of NLRP3 (median time from onset to blood collection 3 h, 1.85 ng/ml vs. 1.11 ng/ml, P = 0.026). NLRP3 level was positively correlated with NIHSS on admission (Spearman ρ = 0.18, P = 0.01) and the association between NLRP3 and MBE was attenuated (OR 1.47, 95 % CI 0.88–2.46, P = 0.138) after adjusting for age and NIHSS. There was no significant difference in other biomarkers between MBE and non-MBE groups. Conclusions There was a trend of association between a higher level of serum concentration of NLRP3 and an increased risk of MBE after ischemic stroke, possibly confounded by the severity of stroke, which is worth further validation in large cohort studies. |
| first_indexed | 2024-12-13T21:19:27Z |
| format | Article |
| id | doaj.art-fc42695a3e4a4cec97679108eb5ae158 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-12-13T21:19:27Z |
| publishDate | 2021-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-fc42695a3e4a4cec97679108eb5ae1582022-12-21T23:31:09ZengBMCBMC Neurology1471-23772021-09-012111710.1186/s12883-021-02369-4Association between serum NLRP3 and malignant brain edema in patients with acute ischemic strokeYanan Wang0Hexiao Huang1Weihong He2Shihong Zhang3Ming Liu4Simiao Wu5Department of Neurology, West China Hospital, Sichuan UniversityWest China School of Medicine, Sichuan UniversityDepartment of Physiology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan UniversityDepartment of Neurology, West China Hospital, Sichuan UniversityDepartment of Neurology, West China Hospital, Sichuan UniversityDepartment of Neurology, West China Hospital, Sichuan UniversityAbstract Background We aimed to explore the association of serum level of the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) and its related inflammatory biomarkers (hypoxia inducible factor-1α, cathepsin B, caspase-1 and matrix metalloproteinase-9) with malignant brain edema (MBE) in patients with acute ischemic stroke. Methods We prospectively enrolled patients with acute ischemic stroke admitted < 24 h from onset of symptoms. Brain CT was performed on admission and blood samples were collected. Repeated brain CT/MRI was performed < 7 days of admission to identify the presence of MBE, defined as neurological deterioration with imaging signs of midline shift or compressed basal cisterns. Logistic regression analysis was performed to assess the association between inflammatory biomarkers and MBE, adjusted for age and National Institutes of Health Stroke Scale (NIHSS). Results 200 patients (69.3 ± 14.3 years; male 55 %) were included for analysis, of whom 26 patients developed MBE (median time from stroke onset to MBE 32.5 h). Compared with patients without MBE, those with MBE had higher level of serum concentration of NLRP3 (median time from onset to blood collection 3 h, 1.85 ng/ml vs. 1.11 ng/ml, P = 0.026). NLRP3 level was positively correlated with NIHSS on admission (Spearman ρ = 0.18, P = 0.01) and the association between NLRP3 and MBE was attenuated (OR 1.47, 95 % CI 0.88–2.46, P = 0.138) after adjusting for age and NIHSS. There was no significant difference in other biomarkers between MBE and non-MBE groups. Conclusions There was a trend of association between a higher level of serum concentration of NLRP3 and an increased risk of MBE after ischemic stroke, possibly confounded by the severity of stroke, which is worth further validation in large cohort studies.https://doi.org/10.1186/s12883-021-02369-4NLRP3Malignant brain edemaAcute ischemic strokeBiomarkers |
| spellingShingle | Yanan Wang Hexiao Huang Weihong He Shihong Zhang Ming Liu Simiao Wu Association between serum NLRP3 and malignant brain edema in patients with acute ischemic stroke BMC Neurology NLRP3 Malignant brain edema Acute ischemic stroke Biomarkers |
| title | Association between serum NLRP3 and malignant brain edema in patients with acute ischemic stroke |
| title_full | Association between serum NLRP3 and malignant brain edema in patients with acute ischemic stroke |
| title_fullStr | Association between serum NLRP3 and malignant brain edema in patients with acute ischemic stroke |
| title_full_unstemmed | Association between serum NLRP3 and malignant brain edema in patients with acute ischemic stroke |
| title_short | Association between serum NLRP3 and malignant brain edema in patients with acute ischemic stroke |
| title_sort | association between serum nlrp3 and malignant brain edema in patients with acute ischemic stroke |
| topic | NLRP3 Malignant brain edema Acute ischemic stroke Biomarkers |
| url | https://doi.org/10.1186/s12883-021-02369-4 |
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