Liquid-Assisted Grinding to Prepare a Cocrystal of Adefovir Dipivoxil Thermodynamically Less Stable than Its Neat Phase

Liquid-Assisted Grinding to Prepare a Cocrystal of Adefovir Dipivoxil Thermodynamically Less Stable than Its Neat Phase

Liquid-assisted grinding was employed to generate a cocrystal of adefovir dipivoxil (AD) and glutaric acid (GLU), which had not been successfully obtained through solution crystallization. The cocrystal formation was confirmed with powder X-ray diffraction, and its thermal stability and release beh...

Full description

Bibliographic Details
Main Authors: Sungyup Jung, Insil Choi, Il Won Kim
Format: Article
Language:English
Published: MDPI AG 2015-11-01
Series:Crystals
Subjects:
cocrystal
grinding
adefovir dipivoxil
stability
release behavior
Online Access:http://www.mdpi.com/2073-4352/5/4/583

Similar Items

Similar Items