Taxonomy of psychopathology based on a neurochemical framework
Introduction Temperament and mental illness are considered to be variations along the same continuum of imbalance in the neurophysiological regulation of behaviour. Objectives This presentation presents the benefits of constructivism approach to psychiatric taxonomies. Methods The presentation revi...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2023-03-01
|
| Series: | European Psychiatry |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933823003632/type/journal_article |
| _version_ | 1827753823657000960 |
|---|---|
| author | I. Trofimova |
| author_facet | I. Trofimova |
| author_sort | I. Trofimova |
| collection | DOAJ |
| description |
Introduction
Temperament and mental illness are considered to be variations along the same continuum of imbalance in the neurophysiological regulation of behaviour.
Objectives
This presentation presents the benefits of constructivism approach to psychiatric taxonomies.
Methods
The presentation reviews findings in neurochemistry that link temperament traits in healthy individuals and symptoms of psychiatric disorders to complex relationships between neurotransmitter systems.
Results
Specialization between neurotransmitter systems underlying temperament traits is analyzed here from a functional ecology perspective that considers the structure of adult temperament corresponding to the functional structure of human activities. In contrast to a more popular search for neuroanatomic biomarkers of psychopathology and temperament traits in healthy individuals, this presentation focuses on neurochemistry-based biomarkers. The roles of monoamine neurotransmitters (serotonin, dopamine, noradrenalin), as well as the roles of acetylcholine, neuropeptides and opioid receptor systems in the regulation of specific dynamical properties of behaviour are summarized within the neurochemical Functional Ensemble of Temperament (FET) model (Table 1) (Trofimova & Robbins, Neurosci Biobehav Rev, 2016, 64, 382-402; Trofimova, Neuropsychobiology, 2021, 80(2), 101-133).
Image 2:
Conclusions
The FET framework allows having a neurochemistry-based structure of a taxonomy that can classify both, healthy bio-psychological traits and symptoms of psychopathology. The presentation will give examples of how the FET framework can be used in psychiatry and clinical psychology.
Disclosure of Interest
None Declared |
| first_indexed | 2024-03-11T07:41:46Z |
| format | Article |
| id | doaj.art-fc443b7adbe043329df4a61c186e1938 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:41:46Z |
| publishDate | 2023-03-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-fc443b7adbe043329df4a61c186e19382023-11-17T05:08:30ZengCambridge University PressEuropean Psychiatry0924-93381778-35852023-03-0166S146S14610.1192/j.eurpsy.2023.363Taxonomy of psychopathology based on a neurochemical frameworkI. Trofimova0Collective Intelligence Lab, Department of Psychiatry and Behavioural Neurosciences, MCMASTER UNIVERSITY, Hamilton, Canada Introduction Temperament and mental illness are considered to be variations along the same continuum of imbalance in the neurophysiological regulation of behaviour. Objectives This presentation presents the benefits of constructivism approach to psychiatric taxonomies. Methods The presentation reviews findings in neurochemistry that link temperament traits in healthy individuals and symptoms of psychiatric disorders to complex relationships between neurotransmitter systems. Results Specialization between neurotransmitter systems underlying temperament traits is analyzed here from a functional ecology perspective that considers the structure of adult temperament corresponding to the functional structure of human activities. In contrast to a more popular search for neuroanatomic biomarkers of psychopathology and temperament traits in healthy individuals, this presentation focuses on neurochemistry-based biomarkers. The roles of monoamine neurotransmitters (serotonin, dopamine, noradrenalin), as well as the roles of acetylcholine, neuropeptides and opioid receptor systems in the regulation of specific dynamical properties of behaviour are summarized within the neurochemical Functional Ensemble of Temperament (FET) model (Table 1) (Trofimova & Robbins, Neurosci Biobehav Rev, 2016, 64, 382-402; Trofimova, Neuropsychobiology, 2021, 80(2), 101-133). Image 2: Conclusions The FET framework allows having a neurochemistry-based structure of a taxonomy that can classify both, healthy bio-psychological traits and symptoms of psychopathology. The presentation will give examples of how the FET framework can be used in psychiatry and clinical psychology. Disclosure of Interest None Declaredhttps://www.cambridge.org/core/product/identifier/S0924933823003632/type/journal_article |
| spellingShingle | I. Trofimova Taxonomy of psychopathology based on a neurochemical framework European Psychiatry |
| title | Taxonomy of psychopathology based on a neurochemical framework |
| title_full | Taxonomy of psychopathology based on a neurochemical framework |
| title_fullStr | Taxonomy of psychopathology based on a neurochemical framework |
| title_full_unstemmed | Taxonomy of psychopathology based on a neurochemical framework |
| title_short | Taxonomy of psychopathology based on a neurochemical framework |
| title_sort | taxonomy of psychopathology based on a neurochemical framework |
| url | https://www.cambridge.org/core/product/identifier/S0924933823003632/type/journal_article |
| work_keys_str_mv | AT itrofimova taxonomyofpsychopathologybasedonaneurochemicalframework |