Pharmacogenomic Analyses Implicate B Cell Developmental Status and <i>MKL1</i> as Determinants of Sensitivity toward Anti-CD20 Monoclonal Antibody Therapy

Pharmacogenomic Analyses Implicate B Cell Developmental Status and <i>MKL1</i> as Determinants of Sensitivity toward Anti-CD20 Monoclonal Antibody Therapy

Monoclonal antibody (mAb) therapy directed against CD20 is an important tool in the treatment of B cell disorders. However, variable patient response and acquired resistance remain important clinical challenges. To identify genetic factors that may influence sensitivity to treatment, the cytotoxic a...

Full description

Bibliographic Details
Main Authors:	George W. Small, Farida S. Akhtari, Adrian J. Green, Tammy M. Havener, Michael Sikes, Julia Quintanhila, Ricardo D. Gonzalez, David M. Reif, Alison A. Motsinger-Reif, Howard L. McLeod, Tim Wiltshire
Format:	Article
Language:	English
Published:	MDPI AG 2023-06-01
Series:	Cells
Subjects:	rituximab (Rituxan<sup>®</sup>) ofatumumab (Arzerra<sup>®</sup>, Kesimpta<sup>®</sup>) obinutuzumab (Gazyva<sup>®</sup>) CD20 (<i>MS4A1</i>) <i>MKL1</i> (<i>MRTFA</i>) <i>TGFB1</i>
Online Access:	https://www.mdpi.com/2073-4409/12/12/1574

Similar Items

Advancing Forensic Chemical Analysis to Classify Wild and Captive Turtles
by: John B. Hopkins, et al.
Published: (2023-09-01)

Evaluation of Radioiodinated Fluoronicotinamide/Fluoropicolinamide-Benzamide Derivatives as Theranostic Agents for Melanoma
by: Chao-Cheng Chen, et al.
Published: (2020-09-01)

Heterotridentate Organomonophosphines in Pt(κ<sup>3</sup>–X<sup>1</sup>P<sup>1</sup>X<sup>2</sup>)(Y) (X<sup>1,2</sup> = N<sup>1,2</sup> or S<sup>1,2</sup>), Pt(κ<sup>3</sup>–P<sup>1</sup>N<sup>1</sup>X<sup>1</sup>)(Y) (X<sup>1</sup> = O, C, S or Se) Pt(κ<sup>3</sup>–P<sup>1</sup>S<sup>1</sup>Cl<sup>1</sup>)(Cl) and Pt(κ<sup>3</sup>–P<sup>1</sup>Si<sup>1</sup>N<sup>1</sup>)(OL)—Structural Aspects
by: Milan Melník, et al.
Published: (2022-12-01)

Combination of Synergic Enzymes and Ultrasounds as an Effective Pretreatment Process to Break Microalgal Cell Wall and Enhance Algal Oil Extraction
by: Cristina Blanco-Llamero, et al.
Published: (2021-08-01)

Short-Term Probiotic Administration Increases Fecal-Anti <i>Candida</i> Activity in Healthy Subjects
by: Massimiliano De Angelis, et al.
Published: (2019-06-01)

Characterization of Bottled Waters by Multielemental Analysis, Stable and Radiogenic Isotopes
by: Tea Zuliani, et al.
Published: (2020-08-01)

Efficacy of Biopesticides in the Management of the Cotton Bollworm, <i>Helicoverpa armigera</i> (Noctuidae), under Field Conditions
by: Lawrence N. Malinga, et al.
Published: (2022-07-01)

Mycorrhizal Benefits of Salt-Stressed <i>Cinnamomum camphora</i> (L.) Presl. May Be Related to P and Mn<sup>2+</sup> Contents in Shoots, Biomass Allocation, and K<sup>+</sup>/Na<sup>+</sup> in Roots and Shoots
by: Yanhong Wang, et al.
Published: (2022-11-01)

Isotopic Niche Analysis of Long-Finned Pilot Whales (<i>Globicephala melas edwardii</i>) in Aotearoa New Zealand Waters
by: Bethany Hinton, et al.
Published: (2022-09-01)

m<sup>1</sup>A RNA Modification in Gene Expression Regulation
by: Hao Jin, et al.
Published: (2022-05-01)

<i>PvARL1</i> Increases Biomass Yield and Enhances Alkaline Tolerance in Switchgrass (<i>Panicum virgatum</i> L.)
by: Xue Li, et al.
Published: (2024-02-01)

Protection and Safety Evaluation of Live Constructions Derived from the Pgm<sup>−</sup> and pPCP1<sup>−</sup> <i>Yersinia pestis</i> Strain
by: Xiuran Wang, et al.
Published: (2020-02-01)

Improved Quantification of <sup>18</sup>F-FDG PET during <sup>131</sup>I-Rituximab Therapy on Mouse Lymphoma Models after <sup>131</sup>I Prompt Emission Correction
by: Young Sub Lee, et al.
Published: (2019-10-01)

A Versatile Broadband Attached Proton Test Experiment for Routine <sup>13</sup>C Nuclear Magnetic Resonance Spectroscopy
by: Peter Bigler, et al.
Published: (2024-02-01)

Measurement of Aβ Amyloid Plaques and Tau Protein in Postmortem Human Alzheimer’s Disease Brain by Autoradiography Using [<sup>18</sup>F]Flotaza, [<sup>125</sup>I]IBETA, [<sup>124/125</sup>I]IPPI and Immunohistochemistry Analysis Using QuPath
by: Rommani Mondal, et al.
Published: (2023-03-01)

Identification of <i>Candida</i> Species from Clinical Samples in a Honduran Tertiary Hospital
by: Kathy Montes, et al.
Published: (2019-11-01)

Fixed Point Results in <i>C</i><sup>🟉</sup>-Algebra-Valued Partial <i>b</i>-Metric Spaces with Related Application
by: Gunaseelan Mani, et al.
Published: (2023-02-01)

Estimation of lymphocyte radiation doses after the ingestion of radionuclides of different tropicity
by: E. I. Tolstykh, et al.
Published: (2021-10-01)

Influence of <i>Clear<sup>T</sup></i> and <i>Clear<sup>T2</sup></i> Agitation Conditions in the Fluorescence Imaging of 3D Spheroids
by: Daniel N. Silva, et al.
Published: (2020-12-01)

A Functional K<sup>+</sup> Channel from Tetraselmis Virus 1, a Member of the <i>Mimiviridae</i>
by: Kerri Kukovetz, et al.
Published: (2020-09-01)

The Different Metabolic Responses of Resistant and Susceptible Wheats to <i>Fusarium graminearum</i> Inoculation
by: Caixiang Liu, et al.
Published: (2022-08-01)

Efficacy of Pyrethroid–Pyriproxyfen and Pyrethroid–Chlorfenapyr Long-Lasting Insecticidal Nets (LLINs) for the Control of Non-<i>Anopheles</i> Mosquitoes: Secondary Analysis from a Cluster Randomised Controlled Trial (cRCT)
by: Constantin J. Adoha, et al.
Published: (2023-04-01)

Immobilization of Cellulolytic Enzymes in Accurel<sup>®</sup> MP1000
by: Julia R. S. Baruque, et al.
Published: (2023-06-01)

<em>H</em>-Umbilical Lagrangian Submanifolds of the Nearly Kähler \( {\mathbb{S}^3\times\mathbb{S}^3} \)
by: Miroslava Antić, et al.
Published: (2020-08-01)

Cloning and Characterization of Two Putative P-Type ATPases from the Marine Microalga <i>Dunaliella maritima</i> Similar to Plant H<sup>+</sup>-ATPases and Their Gene Expression Analysis under Conditions of Hyperosmotic Salt Shock
by: Dmitrii A. Matalin, et al.
Published: (2021-12-01)

Antioxidant Extracts of Nettle (<i>Urtica dioica</i>) Leaves: Evaluation of Extraction Techniques and Solvents
by: María Flórez, et al.
Published: (2022-09-01)

The Effect of Decreased Ca<sup>++</sup>/Mg<sup>++</sup> ATPase Activity on <i>Lactobacillus delbrueckii</i> subsp. <i>bulgaricus</i> sp1.1 Survival during Spray Drying
by: Jialei Sun, et al.
Published: (2023-02-01)

Processing of Fluorescent Proteins May Prevent Detection of Prion Particles in [<i>PSI</i><sup>+</sup>] Cells
by: Andrew G. Matveenko, et al.
Published: (2022-11-01)

Antimicrobial Activity of Commercial Photocatalytic SaniTise™ Window Glass
by: Vambola Kisand, et al.
Published: (2022-02-01)

Extracellular Vesicles-Encapsulated Yeast Prions and What They Can Tell Us about the Physical Nature of Propagons
by: Mehdi Kabani
Published: (2020-12-01)

Embracing [XY<sub>3</sub>]<i><sup>m–</sup></i> and [XY<sub>4</sub>]<i><sup>m–</sup></i> Anions in Salts of [M(bpy)<sub>3</sub>]<i><sup>q</sup></i><sup>+</sup>
by: Edwin C. Constable, et al.
Published: (2023-01-01)

A Thermal Sublimation Generator of <sup>131m</sup>Xe
by: Karolina Kulesz, et al.
Published: (2022-11-01)

Dirichlet Problem with <i>L</i><sup>1</sup>(<i>S</i>) Boundary Values
by: Alexander G. Ramm
Published: (2022-07-01)

Ontogenetic Development of Gill and Na<sup>+</sup>/K<sup>+</sup> ATPase in the Air-Breathing Loach
by: Yaqiu Liu, et al.
Published: (2022-12-01)

Effects of Different β-Lactam Antibiotics on Indirect Tomato (<i>Solanum lycopersicum</i> L.) Shoot Organogenesis and <i>Agrobacterium tumefaciens</i> Growth Inhibition In Vitro
by: Nataliya V. Varlamova, et al.
Published: (2021-06-01)

Assessment of Morpho-Physiological, Biochemical and Antioxidant Responses of Tomato Landraces to Salinity Stress
by: Reem H. Alzahib, et al.
Published: (2021-04-01)

Genome-Wide Identification, Primary Functional Characterization of the <i>NHX</i> Gene Family in <i>Canavalia rosea,</i> and Their Possible Roles for Adaptation to Tropical Coral Reefs
by: Lin Pu, et al.
Published: (2021-12-01)

Algebraic Structures on Smooth Vector Fields
by: Amnah A. Alkinani, et al.
Published: (2023-12-01)

Forensic Application of Stable Isotopes to Distinguish between Wild and Captive Turtles
by: John B. Hopkins, et al.
Published: (2022-11-01)

Associated Charmonium-Bottomonium Production in a Single Boson <i>e</i><sup>+</sup><i>e</i><sup>−</sup> Annihilation
by: Ilia Belov, et al.
Published: (2021-07-01)