No causal effect of tea consumption on cardiovascular diseases: A two-sample Mendelian randomization study
BackgroundNumerous studies have been conducted to investigate the relationship between tea consumption and the risk of cardiovascular diseases (CVD); however, no conclusive results have been achieved. We conducted a Mendelian randomization (MR) study to elucidate the causal associations between tea...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.870972/full |
| _version_ | 1798037151524323328 |
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| author | Lu Chen Xingang Sun Liangrong Zheng |
| author_facet | Lu Chen Xingang Sun Liangrong Zheng |
| author_sort | Lu Chen |
| collection | DOAJ |
| description | BackgroundNumerous studies have been conducted to investigate the relationship between tea consumption and the risk of cardiovascular diseases (CVD); however, no conclusive results have been achieved. We conducted a Mendelian randomization (MR) study to elucidate the causal associations between tea consumption and several CVD outcomes, including coronary artery disease (CAD), myocardial infarction (MI), atrial fibrillation (AF), and heart failure (HF).MethodsIndependent single-nucleotide polymorphisms (SNPs) genome-wide significantly associated with tea consumption were used as instrumental variables (IVs). Summary statistics for CVD outcomes were obtained from the corresponding genetic consortia and the FinnGen consortium. The inverse-variance weighted (IVW) method was the primary analytical method, and MR estimates from different data sources were combined using fixed-effects meta-analysis. Supplementary MR analyses, including the weighted median, MR-Egger, and the MR pleiotropy residual sum and outlier methods, were conducted to evaluate the robustness of the results. Further MR analyses were repeated by including more genetic variants at a higher P-value threshold.ResultsWe found that genetically predicted tea consumption was not causally associated with any CVD outcomes in the IVW method using data from large genetic consortia [CAD: odds ratio (OR) = 1.00, 95% confidence interval (CI), 0.91, 1.10, P = 0.997; MI: OR = 0.98, 95% CI, 0.90, 1.08, P = 0.751; AF: OR = 0.97, 95% CI, 0.92, 1.03, P = 0.350; HF: OR = 0.96, 95% CI, 0.88, 1.05, P = 0.401] or the FinnGen consortium (CAD: OR = 1.06, 95% CI, 0.96, 1.17, P = 0.225; MI: OR = 1.01, 95% CI, 0.89, 1.15, P = 0.882; AF: OR = 1.00, 95% CI, 0.88, 1.14, P = 0.994; HF: OR = 0.96, 95% CI, 0.88, 1.04, P = 0.362). The results were robust and consistent across meta-analysis, supplementary MR analyses, and analyses with more IVs included.ConclusionThis MR study revealed no causal association between tea consumption and four CVD outcomes, suggesting that tea consumption may not be beneficial for the primary prevention of CVD. |
| first_indexed | 2024-04-11T21:22:41Z |
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| id | doaj.art-fc4615c28798476a99dedfa8adec3569 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-11T21:22:41Z |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-fc4615c28798476a99dedfa8adec35692022-12-22T04:02:34ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-09-01910.3389/fcvm.2022.870972870972No causal effect of tea consumption on cardiovascular diseases: A two-sample Mendelian randomization studyLu ChenXingang SunLiangrong ZhengBackgroundNumerous studies have been conducted to investigate the relationship between tea consumption and the risk of cardiovascular diseases (CVD); however, no conclusive results have been achieved. We conducted a Mendelian randomization (MR) study to elucidate the causal associations between tea consumption and several CVD outcomes, including coronary artery disease (CAD), myocardial infarction (MI), atrial fibrillation (AF), and heart failure (HF).MethodsIndependent single-nucleotide polymorphisms (SNPs) genome-wide significantly associated with tea consumption were used as instrumental variables (IVs). Summary statistics for CVD outcomes were obtained from the corresponding genetic consortia and the FinnGen consortium. The inverse-variance weighted (IVW) method was the primary analytical method, and MR estimates from different data sources were combined using fixed-effects meta-analysis. Supplementary MR analyses, including the weighted median, MR-Egger, and the MR pleiotropy residual sum and outlier methods, were conducted to evaluate the robustness of the results. Further MR analyses were repeated by including more genetic variants at a higher P-value threshold.ResultsWe found that genetically predicted tea consumption was not causally associated with any CVD outcomes in the IVW method using data from large genetic consortia [CAD: odds ratio (OR) = 1.00, 95% confidence interval (CI), 0.91, 1.10, P = 0.997; MI: OR = 0.98, 95% CI, 0.90, 1.08, P = 0.751; AF: OR = 0.97, 95% CI, 0.92, 1.03, P = 0.350; HF: OR = 0.96, 95% CI, 0.88, 1.05, P = 0.401] or the FinnGen consortium (CAD: OR = 1.06, 95% CI, 0.96, 1.17, P = 0.225; MI: OR = 1.01, 95% CI, 0.89, 1.15, P = 0.882; AF: OR = 1.00, 95% CI, 0.88, 1.14, P = 0.994; HF: OR = 0.96, 95% CI, 0.88, 1.04, P = 0.362). The results were robust and consistent across meta-analysis, supplementary MR analyses, and analyses with more IVs included.ConclusionThis MR study revealed no causal association between tea consumption and four CVD outcomes, suggesting that tea consumption may not be beneficial for the primary prevention of CVD.https://www.frontiersin.org/articles/10.3389/fcvm.2022.870972/fulltea consumptioncoronary artery diseasemyocardial infarctionatrial fibrillationheart failureMendelian randomization |
| spellingShingle | Lu Chen Xingang Sun Liangrong Zheng No causal effect of tea consumption on cardiovascular diseases: A two-sample Mendelian randomization study Frontiers in Cardiovascular Medicine tea consumption coronary artery disease myocardial infarction atrial fibrillation heart failure Mendelian randomization |
| title | No causal effect of tea consumption on cardiovascular diseases: A two-sample Mendelian randomization study |
| title_full | No causal effect of tea consumption on cardiovascular diseases: A two-sample Mendelian randomization study |
| title_fullStr | No causal effect of tea consumption on cardiovascular diseases: A two-sample Mendelian randomization study |
| title_full_unstemmed | No causal effect of tea consumption on cardiovascular diseases: A two-sample Mendelian randomization study |
| title_short | No causal effect of tea consumption on cardiovascular diseases: A two-sample Mendelian randomization study |
| title_sort | no causal effect of tea consumption on cardiovascular diseases a two sample mendelian randomization study |
| topic | tea consumption coronary artery disease myocardial infarction atrial fibrillation heart failure Mendelian randomization |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.870972/full |
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