Does Anti-Müllerian hormone vary during a menstrual cycle? A systematic review and meta-analysis
Abstract Objective Numerous studies have indicated that the level of the Anti-Müllerian hormone (AMH), one of the main markers for the ovarian reserve, does not fluctuate throughout a menstrual cycle, while some studies have rejected this finding. The purpose of this systematic and meta-analysis stu...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-07-01
|
| Series: | Journal of Ovarian Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13048-022-01006-z |
| _version_ | 1828079927911514112 |
|---|---|
| author | Rasa Khodavirdilou Marjaneh Pournaghi Yeganeh Rastgar Rezaei Khadijeh Hajizadeh Lida Khodavirdilou Farzin Javid Kobra Hamdi Mahnaz Shahnazi Mohammad Nouri Amir Fattahi Matthias W. Beckmann Ralf Dittrich |
| author_facet | Rasa Khodavirdilou Marjaneh Pournaghi Yeganeh Rastgar Rezaei Khadijeh Hajizadeh Lida Khodavirdilou Farzin Javid Kobra Hamdi Mahnaz Shahnazi Mohammad Nouri Amir Fattahi Matthias W. Beckmann Ralf Dittrich |
| author_sort | Rasa Khodavirdilou |
| collection | DOAJ |
| description | Abstract Objective Numerous studies have indicated that the level of the Anti-Müllerian hormone (AMH), one of the main markers for the ovarian reserve, does not fluctuate throughout a menstrual cycle, while some studies have rejected this finding. The purpose of this systematic and meta-analysis study is to consensus on all contradictory studies that have measured AMH levels throughout the menstrual cycle and to investigate the exact extent of AMH variation in a cycle. Methods The protocol for this meta-analysis was registered at PROSPERO before data extraction. Relevant studies were identified by systematic search in PubMed, ScienceDirect, Embase, Cochrane Library, and Google Scholar with no limitation on publication date. Longitudinal studies which have evaluated AMH levels in the follicular and luteal phases of an unstimulated (natural) menstrual cycle in healthy women without endocrinology or ovarian disorders were included. We used the JBI Critical Appraisal Checklist for assessing the quality of studies found eligible for meta-analysis. Results A total of 11 studies involving 733 women with regular menstrual cycles were included. The results showed that the AMH level in the follicular phase was significantly higher than in the luteal phase (95% Cl = 0.11 [0.01 to 0.21]; p < 0.05) and it varies about 11.5% from the luteal phase. The analysis of studies which had also examined the ovulatory phase (n = 380) showed that the serum levels of AMH in the ovulatory phase (about 2.02 ng/ml) did not significantly vary compared to follicular (95% Cl = 0.11 [-0.10 to 0.33]; p = 0.30) and luteal (95% Cl = 0.06 [-0.08 to 0.20]; p = 0.43) phases. Conclusions According to the results of this study, AMH levels differ between follicular and luteal phases which might be due to ovarian response to the gonadotropins. It seems the phase of AMH measurement needs to be considered for interpretation of the serum AMH test. |
| first_indexed | 2024-04-11T03:10:06Z |
| format | Article |
| id | doaj.art-fc462c8cb5c14f66abc92ff1d2b1bfae |
| institution | Directory Open Access Journal |
| issn | 1757-2215 |
| language | English |
| last_indexed | 2024-04-11T03:10:06Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Ovarian Research |
| spelling | doaj.art-fc462c8cb5c14f66abc92ff1d2b1bfae2023-01-02T12:01:55ZengBMCJournal of Ovarian Research1757-22152022-07-0115111210.1186/s13048-022-01006-zDoes Anti-Müllerian hormone vary during a menstrual cycle? A systematic review and meta-analysisRasa Khodavirdilou0Marjaneh Pournaghi1Yeganeh Rastgar Rezaei2Khadijeh Hajizadeh3Lida Khodavirdilou4Farzin Javid5Kobra Hamdi6Mahnaz Shahnazi7Mohammad Nouri8Amir Fattahi9Matthias W. Beckmann10Ralf Dittrich11Womenʼs Reproductive Health Research Center, Tabriz University of Medical SciencesWomenʼs Reproductive Health Research Center, Tabriz University of Medical SciencesDepartment of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical SciencesDepartment of Midwifery, Faculty of Nursing and Midwifery, Tabriz University of Medical SciencesFaculty of Pharmacy, Tabriz University of Medical SciencesWomenʼs Reproductive Health Research Center, Tabriz University of Medical SciencesWomenʼs Reproductive Health Research Center, Tabriz University of Medical SciencesDepartment of Midwifery, Faculty of Nursing and Midwifery, Tabriz University of Medical SciencesDepartment of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical SciencesWomenʼs Reproductive Health Research Center, Tabriz University of Medical SciencesDepartment of Obstetrics and Gynecology, Erlangen University Hospital, Friedrich-Alexander University of Erlangen–NürnbergDepartment of Obstetrics and Gynecology, Erlangen University Hospital, Friedrich-Alexander University of Erlangen–NürnbergAbstract Objective Numerous studies have indicated that the level of the Anti-Müllerian hormone (AMH), one of the main markers for the ovarian reserve, does not fluctuate throughout a menstrual cycle, while some studies have rejected this finding. The purpose of this systematic and meta-analysis study is to consensus on all contradictory studies that have measured AMH levels throughout the menstrual cycle and to investigate the exact extent of AMH variation in a cycle. Methods The protocol for this meta-analysis was registered at PROSPERO before data extraction. Relevant studies were identified by systematic search in PubMed, ScienceDirect, Embase, Cochrane Library, and Google Scholar with no limitation on publication date. Longitudinal studies which have evaluated AMH levels in the follicular and luteal phases of an unstimulated (natural) menstrual cycle in healthy women without endocrinology or ovarian disorders were included. We used the JBI Critical Appraisal Checklist for assessing the quality of studies found eligible for meta-analysis. Results A total of 11 studies involving 733 women with regular menstrual cycles were included. The results showed that the AMH level in the follicular phase was significantly higher than in the luteal phase (95% Cl = 0.11 [0.01 to 0.21]; p < 0.05) and it varies about 11.5% from the luteal phase. The analysis of studies which had also examined the ovulatory phase (n = 380) showed that the serum levels of AMH in the ovulatory phase (about 2.02 ng/ml) did not significantly vary compared to follicular (95% Cl = 0.11 [-0.10 to 0.33]; p = 0.30) and luteal (95% Cl = 0.06 [-0.08 to 0.20]; p = 0.43) phases. Conclusions According to the results of this study, AMH levels differ between follicular and luteal phases which might be due to ovarian response to the gonadotropins. It seems the phase of AMH measurement needs to be considered for interpretation of the serum AMH test.https://doi.org/10.1186/s13048-022-01006-zAnti mullerian hormoneMenstrual cycleFullicular phaseLuteal phaseOvulationSystematic review |
| spellingShingle | Rasa Khodavirdilou Marjaneh Pournaghi Yeganeh Rastgar Rezaei Khadijeh Hajizadeh Lida Khodavirdilou Farzin Javid Kobra Hamdi Mahnaz Shahnazi Mohammad Nouri Amir Fattahi Matthias W. Beckmann Ralf Dittrich Does Anti-Müllerian hormone vary during a menstrual cycle? A systematic review and meta-analysis Journal of Ovarian Research Anti mullerian hormone Menstrual cycle Fullicular phase Luteal phase Ovulation Systematic review |
| title | Does Anti-Müllerian hormone vary during a menstrual cycle? A systematic review and meta-analysis |
| title_full | Does Anti-Müllerian hormone vary during a menstrual cycle? A systematic review and meta-analysis |
| title_fullStr | Does Anti-Müllerian hormone vary during a menstrual cycle? A systematic review and meta-analysis |
| title_full_unstemmed | Does Anti-Müllerian hormone vary during a menstrual cycle? A systematic review and meta-analysis |
| title_short | Does Anti-Müllerian hormone vary during a menstrual cycle? A systematic review and meta-analysis |
| title_sort | does anti mullerian hormone vary during a menstrual cycle a systematic review and meta analysis |
| topic | Anti mullerian hormone Menstrual cycle Fullicular phase Luteal phase Ovulation Systematic review |
| url | https://doi.org/10.1186/s13048-022-01006-z |
| work_keys_str_mv | AT rasakhodavirdilou doesantimullerianhormonevaryduringamenstrualcycleasystematicreviewandmetaanalysis AT marjanehpournaghi doesantimullerianhormonevaryduringamenstrualcycleasystematicreviewandmetaanalysis AT yeganehrastgarrezaei doesantimullerianhormonevaryduringamenstrualcycleasystematicreviewandmetaanalysis AT khadijehhajizadeh doesantimullerianhormonevaryduringamenstrualcycleasystematicreviewandmetaanalysis AT lidakhodavirdilou doesantimullerianhormonevaryduringamenstrualcycleasystematicreviewandmetaanalysis AT farzinjavid doesantimullerianhormonevaryduringamenstrualcycleasystematicreviewandmetaanalysis AT kobrahamdi doesantimullerianhormonevaryduringamenstrualcycleasystematicreviewandmetaanalysis AT mahnazshahnazi doesantimullerianhormonevaryduringamenstrualcycleasystematicreviewandmetaanalysis AT mohammadnouri doesantimullerianhormonevaryduringamenstrualcycleasystematicreviewandmetaanalysis AT amirfattahi doesantimullerianhormonevaryduringamenstrualcycleasystematicreviewandmetaanalysis AT matthiaswbeckmann doesantimullerianhormonevaryduringamenstrualcycleasystematicreviewandmetaanalysis AT ralfdittrich doesantimullerianhormonevaryduringamenstrualcycleasystematicreviewandmetaanalysis |