Demographic and clinical characteristics of patients with chronic HCV infection in a third-level IMSS Hospital in Mexico City
Introduction and Objectives: : Hepatitis C virus (HCV) infection is a major cause of chronic liver disease, there are approximately 71 million infected individuals worldwide, up to 40% of them will have spontaneous resolution and60% will develop chronic infection with risk of developing cirrhosis an...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Annals of Hepatology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S166526812400228X |
| _version_ | 1827325534834524160 |
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| author | Areli Torres-Castro Christopher J. Toranzo-González Javier I. Carrillo-Rojas Sarahi Ontiveros-López Iván A. Borunda-Sáenz Carlos M. Del Real-Calzada Mauricio Castillo-Barradas María T. Rizo-Robles |
| author_facet | Areli Torres-Castro Christopher J. Toranzo-González Javier I. Carrillo-Rojas Sarahi Ontiveros-López Iván A. Borunda-Sáenz Carlos M. Del Real-Calzada Mauricio Castillo-Barradas María T. Rizo-Robles |
| author_sort | Areli Torres-Castro |
| collection | DOAJ |
| description | Introduction and Objectives: : Hepatitis C virus (HCV) infection is a major cause of chronic liver disease, there are approximately 71 million infected individuals worldwide, up to 40% of them will have spontaneous resolution and60% will develop chronic infection with risk of developing cirrhosis and hepatocellular carcinoma.In Mexico it is the fourth cause of death and one of the main causes of disability. Current HCV treatment with direct-acting antivirals (ADDs) has a high rate of sustained viral response that ensures the cure of the infection, decreases the progression of liver fibrosis and decompensation rates in patients with cirrhosis. This study aimed to describe the demographic and clinical characteristics of patients with chronic HCV infection, treated at a third-level care hospital in Mexico City. Materials and Patients: A retrospective cohort study in a part of the patients from the HCV clinic of an IMSS third-levelhospital, which included cases with confirmed HCV infection, who received treatment with direct-acting antivirals +/- ribavirin, in the period of 2017-2022. Results: Data from 222 treated patients was collected; a mean age of 53 years was reported, with a male-female ratio of 1:1. Among candidates for treatment with direct-acting antivirals 50.5% had advanced chronic liver disease at the time of diagnosis. Of these patients 76.1% were classified as a compensated chronic liver disease with a stage of Child Pugh A and 86.7% had a MELD-Na score of less than 14 points. The sustained virologic response rate in this population was 99%. Conclusions: It was observed that the collected treated population was on average in the sixth decade of life, with no gender predilection. Half of this population had advanced chronic liver disease at the time of diagnosis and initiation of treatment with direct antivirals. The majority of patients were in a compensated stage by Child Pugh, and showed a low MELD-Na score which was favorable for follow-up and subsequent management. |
| first_indexed | 2024-03-07T14:30:37Z |
| format | Article |
| id | doaj.art-fc48167cb6d24c1c9173c1fcd5f237f9 |
| institution | Directory Open Access Journal |
| issn | 1665-2681 |
| language | English |
| last_indexed | 2024-03-07T14:30:37Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj.art-fc48167cb6d24c1c9173c1fcd5f237f92024-03-06T05:26:08ZengElsevierAnnals of Hepatology1665-26812024-02-0129101434Demographic and clinical characteristics of patients with chronic HCV infection in a third-level IMSS Hospital in Mexico CityAreli Torres-Castro0Christopher J. Toranzo-González1Javier I. Carrillo-Rojas2Sarahi Ontiveros-López3Iván A. Borunda-Sáenz4Carlos M. Del Real-Calzada5Mauricio Castillo-Barradas6María T. Rizo-Robles7IMSS, UMAE Hospital of Specialties ''Dr. Antonio Fraga Mouret'', CMN ''La Raza''IMSS, UMAE Hospital of Specialties ''Dr. Antonio Fraga Mouret'', CMN ''La Raza''IMSS, UMAE Hospital of Specialties ''Dr. Antonio Fraga Mouret'', CMN ''La Raza''IMSS, UMAE Hospital of Specialties ''Dr. Antonio Fraga Mouret'', CMN ''La Raza''IMSS, UMAE Hospital of Specialties ''Dr. Antonio Fraga Mouret'', CMN ''La Raza''IMSS, UMAE Hospital of Specialties ''Dr. Antonio Fraga Mouret'', CMN ''La Raza''IMSS, UMAE Hospital of Specialties ''Dr. Antonio Fraga Mouret'', CMN ''La Raza''IMSS, UMAE Hospital of Specialties ''Dr. Antonio Fraga Mouret'', CMN ''La Raza''Introduction and Objectives: : Hepatitis C virus (HCV) infection is a major cause of chronic liver disease, there are approximately 71 million infected individuals worldwide, up to 40% of them will have spontaneous resolution and60% will develop chronic infection with risk of developing cirrhosis and hepatocellular carcinoma.In Mexico it is the fourth cause of death and one of the main causes of disability. Current HCV treatment with direct-acting antivirals (ADDs) has a high rate of sustained viral response that ensures the cure of the infection, decreases the progression of liver fibrosis and decompensation rates in patients with cirrhosis. This study aimed to describe the demographic and clinical characteristics of patients with chronic HCV infection, treated at a third-level care hospital in Mexico City. Materials and Patients: A retrospective cohort study in a part of the patients from the HCV clinic of an IMSS third-levelhospital, which included cases with confirmed HCV infection, who received treatment with direct-acting antivirals +/- ribavirin, in the period of 2017-2022. Results: Data from 222 treated patients was collected; a mean age of 53 years was reported, with a male-female ratio of 1:1. Among candidates for treatment with direct-acting antivirals 50.5% had advanced chronic liver disease at the time of diagnosis. Of these patients 76.1% were classified as a compensated chronic liver disease with a stage of Child Pugh A and 86.7% had a MELD-Na score of less than 14 points. The sustained virologic response rate in this population was 99%. Conclusions: It was observed that the collected treated population was on average in the sixth decade of life, with no gender predilection. Half of this population had advanced chronic liver disease at the time of diagnosis and initiation of treatment with direct antivirals. The majority of patients were in a compensated stage by Child Pugh, and showed a low MELD-Na score which was favorable for follow-up and subsequent management.http://www.sciencedirect.com/science/article/pii/S166526812400228X |
| spellingShingle | Areli Torres-Castro Christopher J. Toranzo-González Javier I. Carrillo-Rojas Sarahi Ontiveros-López Iván A. Borunda-Sáenz Carlos M. Del Real-Calzada Mauricio Castillo-Barradas María T. Rizo-Robles Demographic and clinical characteristics of patients with chronic HCV infection in a third-level IMSS Hospital in Mexico City Annals of Hepatology |
| title | Demographic and clinical characteristics of patients with chronic HCV infection in a third-level IMSS Hospital in Mexico City |
| title_full | Demographic and clinical characteristics of patients with chronic HCV infection in a third-level IMSS Hospital in Mexico City |
| title_fullStr | Demographic and clinical characteristics of patients with chronic HCV infection in a third-level IMSS Hospital in Mexico City |
| title_full_unstemmed | Demographic and clinical characteristics of patients with chronic HCV infection in a third-level IMSS Hospital in Mexico City |
| title_short | Demographic and clinical characteristics of patients with chronic HCV infection in a third-level IMSS Hospital in Mexico City |
| title_sort | demographic and clinical characteristics of patients with chronic hcv infection in a third level imss hospital in mexico city |
| url | http://www.sciencedirect.com/science/article/pii/S166526812400228X |
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