EVIDENCE BASE OF ETHYLMETHYLHYDROXYPYRIDINE SUCCINATE USE IN PATIENTS WITH STROKE AND ITS CONSEQUENCES
Review of clinical studies on the use of ethylmethylhydroxypyridine succinate (EMHPS) medications in patients with stroke and its consequences is presented. EMHPS drugs are widely used in routine clinical practice in Russia, despite the absence of clear evidence of neuroprotection in stroke. Most cl...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2015-09-01
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| Series: | Рациональная фармакотерапия в кардиологии |
| Subjects: | |
| Online Access: | https://www.rpcardio.online/jour/article/view/194 |
| _version_ | 1826949927889010688 |
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| author | A. D. Ehrlikh N. A. Gratsianskii |
| author_facet | A. D. Ehrlikh N. A. Gratsianskii |
| author_sort | A. D. Ehrlikh |
| collection | DOAJ |
| description | Review of clinical studies on the use of ethylmethylhydroxypyridine succinate (EMHPS) medications in patients with stroke and its consequences is presented. EMHPS drugs are widely used in routine clinical practice in Russia, despite the absence of clear evidence of neuroprotection in stroke. Most clinical studies of EMHPS drugs were small, nonrandomized and had "soft" endpoints. The results in many papers are presented without appropriate statistical comparisons. In many studies of EMHPS drugs different administration regimens were used that are often not described in the drug instructions and the federal guidelines. Correlation between EMHPS use and decreasing mortality after stroke was not shown in any of the studies. Existing studies have not provided compelling evidence for widespread clinical use of EMHPS drugs in patients with stroke and its consequences. |
| first_indexed | 2024-03-08T14:06:39Z |
| format | Article |
| id | doaj.art-fc48244af760471981085f44c4136673 |
| institution | Directory Open Access Journal |
| issn | 1819-6446 2225-3653 |
| language | English |
| last_indexed | 2025-02-17T22:22:44Z |
| publishDate | 2015-09-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj.art-fc48244af760471981085f44c41366732024-12-04T11:48:00ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532015-09-0110444845610.20996/1819-6446-2014-10-4-448-456194EVIDENCE BASE OF ETHYLMETHYLHYDROXYPYRIDINE SUCCINATE USE IN PATIENTS WITH STROKE AND ITS CONSEQUENCESA. D. Ehrlikh0N. A. Gratsianskii1Scientific Research Institute of Physical-Chemical Medicine, Federal Medical and Biological AgencyScientific Research Institute of Physical-Chemical Medicine, Federal Medical and Biological AgencyReview of clinical studies on the use of ethylmethylhydroxypyridine succinate (EMHPS) medications in patients with stroke and its consequences is presented. EMHPS drugs are widely used in routine clinical practice in Russia, despite the absence of clear evidence of neuroprotection in stroke. Most clinical studies of EMHPS drugs were small, nonrandomized and had "soft" endpoints. The results in many papers are presented without appropriate statistical comparisons. In many studies of EMHPS drugs different administration regimens were used that are often not described in the drug instructions and the federal guidelines. Correlation between EMHPS use and decreasing mortality after stroke was not shown in any of the studies. Existing studies have not provided compelling evidence for widespread clinical use of EMHPS drugs in patients with stroke and its consequences.https://www.rpcardio.online/jour/article/view/194ethylmethylhydroxypyridine succinatestroketrials |
| spellingShingle | A. D. Ehrlikh N. A. Gratsianskii EVIDENCE BASE OF ETHYLMETHYLHYDROXYPYRIDINE SUCCINATE USE IN PATIENTS WITH STROKE AND ITS CONSEQUENCES Рациональная фармакотерапия в кардиологии ethylmethylhydroxypyridine succinate stroke trials |
| title | EVIDENCE BASE OF ETHYLMETHYLHYDROXYPYRIDINE SUCCINATE USE IN PATIENTS WITH STROKE AND ITS CONSEQUENCES |
| title_full | EVIDENCE BASE OF ETHYLMETHYLHYDROXYPYRIDINE SUCCINATE USE IN PATIENTS WITH STROKE AND ITS CONSEQUENCES |
| title_fullStr | EVIDENCE BASE OF ETHYLMETHYLHYDROXYPYRIDINE SUCCINATE USE IN PATIENTS WITH STROKE AND ITS CONSEQUENCES |
| title_full_unstemmed | EVIDENCE BASE OF ETHYLMETHYLHYDROXYPYRIDINE SUCCINATE USE IN PATIENTS WITH STROKE AND ITS CONSEQUENCES |
| title_short | EVIDENCE BASE OF ETHYLMETHYLHYDROXYPYRIDINE SUCCINATE USE IN PATIENTS WITH STROKE AND ITS CONSEQUENCES |
| title_sort | evidence base of ethylmethylhydroxypyridine succinate use in patients with stroke and its consequences |
| topic | ethylmethylhydroxypyridine succinate stroke trials |
| url | https://www.rpcardio.online/jour/article/view/194 |
| work_keys_str_mv | AT adehrlikh evidencebaseofethylmethylhydroxypyridinesuccinateuseinpatientswithstrokeanditsconsequences AT nagratsianskii evidencebaseofethylmethylhydroxypyridinesuccinateuseinpatientswithstrokeanditsconsequences |