Gestational Diabetes Mellitus and Hormonal Alteration
Gestational Diabetes Mellitus is known as carbohydrate intolerance first detected during pregnancy. Pregnancy is periods of intense hormonal changes. The aim of the present study was to investigate a possible relation between the changes in serum hormones such as Luteinizing hormone (LH) , follicle...
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| Format: | Article |
| Language: | English |
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College of Pharmacy University of Baghdad
2017-01-01
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| Series: | Iraqi Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/24 |
| _version_ | 1819227596123013120 |
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| author | bijps Sura A. Abdul Sattar Amer H. Abdulla Aufaira Sh. Nsaif |
| author_facet | bijps Sura A. Abdul Sattar Amer H. Abdulla Aufaira Sh. Nsaif |
| author_sort | bijps |
| collection | DOAJ |
| description | Gestational Diabetes Mellitus is known as carbohydrate intolerance first detected during pregnancy. Pregnancy is periods of intense hormonal changes. The aim of the present study was to investigate a possible relation between the changes in serum hormones such as Luteinizing hormone (LH) , follicle stimulating hormone(FSH), Progesterone, and Prolactin with gestational diabetes mellitus. Thirty patients with gestational diabetes mellitus aged (22 -40) year attending the national center for treatment and research of diabetes/ AL-Mustansiriya University in Baghdad and 29 controls aged (20-39) year were participated. Hormonal tests including, FSH, LH, Progesterone, and Prolactin were detected by using Enzyme Linked Fluorescent Assay (ELFA) kits. The demographic characteristics of gestational diabetes mellitus indicated that the most commonly affected age at (20-29) year (50%) ,60% of patients had Body Mass Index(BMI) at ≥ 30kg/m2+, 76.6% of patients at first trimester of pregnancy, 23.3% had previous abortion,60% at the first pregnancy ,and 46.6% of patients had urine protein with one plus. A highly significant increase (p≤0.001) in Fasting serum glucose(FSG), LH, FSH, progesterone, and prolactin were observed in sera of gestational diabetes mellitus patients in comparison to that of control pregnancy group. A non-significant correlation of FSG with age, BMI, LH, FSH, and progesterone were demonstrated. While a significant positive correlation of FBS with prolactin was found. It is conclude that higher prolactin level in pregnancy possibly played a role in gestational diabetes mellitus partly by impairing the functions of insulin, and result in hyperglycemia. |
| first_indexed | 2024-12-23T10:43:54Z |
| format | Article |
| id | doaj.art-fc483ea09afc45baac712eb166175298 |
| institution | Directory Open Access Journal |
| issn | 2521-3512 1683-3597 |
| language | English |
| last_indexed | 2024-12-23T10:43:54Z |
| publishDate | 2017-01-01 |
| publisher | College of Pharmacy University of Baghdad |
| record_format | Article |
| series | Iraqi Journal of Pharmaceutical Sciences |
| spelling | doaj.art-fc483ea09afc45baac712eb1661752982022-12-21T17:50:06ZengCollege of Pharmacy University of BaghdadIraqi Journal of Pharmaceutical Sciences2521-35121683-35972017-01-01251Gestational Diabetes Mellitus and Hormonal AlterationbijpsSura A. Abdul SattarAmer H. AbdullaAufaira Sh. NsaifGestational Diabetes Mellitus is known as carbohydrate intolerance first detected during pregnancy. Pregnancy is periods of intense hormonal changes. The aim of the present study was to investigate a possible relation between the changes in serum hormones such as Luteinizing hormone (LH) , follicle stimulating hormone(FSH), Progesterone, and Prolactin with gestational diabetes mellitus. Thirty patients with gestational diabetes mellitus aged (22 -40) year attending the national center for treatment and research of diabetes/ AL-Mustansiriya University in Baghdad and 29 controls aged (20-39) year were participated. Hormonal tests including, FSH, LH, Progesterone, and Prolactin were detected by using Enzyme Linked Fluorescent Assay (ELFA) kits. The demographic characteristics of gestational diabetes mellitus indicated that the most commonly affected age at (20-29) year (50%) ,60% of patients had Body Mass Index(BMI) at ≥ 30kg/m2+, 76.6% of patients at first trimester of pregnancy, 23.3% had previous abortion,60% at the first pregnancy ,and 46.6% of patients had urine protein with one plus. A highly significant increase (p≤0.001) in Fasting serum glucose(FSG), LH, FSH, progesterone, and prolactin were observed in sera of gestational diabetes mellitus patients in comparison to that of control pregnancy group. A non-significant correlation of FSG with age, BMI, LH, FSH, and progesterone were demonstrated. While a significant positive correlation of FBS with prolactin was found. It is conclude that higher prolactin level in pregnancy possibly played a role in gestational diabetes mellitus partly by impairing the functions of insulin, and result in hyperglycemia.https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/24Gestational diabetes, FSH, LH, Progesterone, Prolactin. |
| spellingShingle | bijps Sura A. Abdul Sattar Amer H. Abdulla Aufaira Sh. Nsaif Gestational Diabetes Mellitus and Hormonal Alteration Iraqi Journal of Pharmaceutical Sciences Gestational diabetes, FSH, LH, Progesterone, Prolactin. |
| title | Gestational Diabetes Mellitus and Hormonal Alteration |
| title_full | Gestational Diabetes Mellitus and Hormonal Alteration |
| title_fullStr | Gestational Diabetes Mellitus and Hormonal Alteration |
| title_full_unstemmed | Gestational Diabetes Mellitus and Hormonal Alteration |
| title_short | Gestational Diabetes Mellitus and Hormonal Alteration |
| title_sort | gestational diabetes mellitus and hormonal alteration |
| topic | Gestational diabetes, FSH, LH, Progesterone, Prolactin. |
| url | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/24 |
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