Mechanistic Modeling of Maternal Lymphoid and Fetal Plasma Antiretroviral Exposure During the Third Trimester

Mechanistic Modeling of Maternal Lymphoid and Fetal Plasma Antiretroviral Exposure During the Third Trimester

Pregnancy-induced changes in plasma pharmacokinetics of many antiretrovirals (ARV) are well-established. Current knowledge about the extent of ARV exposure in lymphoid tissues of pregnant women and within the fetal compartment is limited due to their inaccessibility. Subtherapeutic ARV concentration...

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Bibliographic Details
Main Authors: Babajide Shenkoya, Shakir Atoyebi, Ibrahim Eniayewu, Abdulafeez Akinloye, Adeniyi Olagunju
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Pediatrics
Subjects:
pregnancy
antiretroviral
lymph
pharmacokinetics
PBPK
fetus
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2021.734122/full

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