Deregulated Metabolic Pathways in Ovarian Cancer: Cause and Consequence
Ovarian cancers are tumors that originate from the different cells of the ovary and account for almost 4% of all the cancers in women globally. More than 30 types of tumors have been identified based on the cellular origins. Epithelial ovarian cancer (EOC) is the most common and lethal type of ovari...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
|
| Series: | Metabolites |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-1989/13/4/560 |
| _version_ | 1797604350919442432 |
|---|---|
| author | Roopak Murali Vaishnavi Balasubramaniam Satish Srinivas Sandhya Sundaram Ganesh Venkatraman Sudha Warrier Arun Dharmarajan Rajesh Kumar Gandhirajan |
| author_facet | Roopak Murali Vaishnavi Balasubramaniam Satish Srinivas Sandhya Sundaram Ganesh Venkatraman Sudha Warrier Arun Dharmarajan Rajesh Kumar Gandhirajan |
| author_sort | Roopak Murali |
| collection | DOAJ |
| description | Ovarian cancers are tumors that originate from the different cells of the ovary and account for almost 4% of all the cancers in women globally. More than 30 types of tumors have been identified based on the cellular origins. Epithelial ovarian cancer (EOC) is the most common and lethal type of ovarian cancer which can be further divided into high-grade serous, low-grade serous, endometrioid, clear cell, and mucinous carcinoma. Ovarian carcinogenesis has been long attributed to endometriosis which is a chronic inflammation of the reproductive tract leading to progressive accumulation of mutations. Due to the advent of multi-omics datasets, the consequences of somatic mutations and their role in altered tumor metabolism has been well elucidated. Several oncogenes and tumor suppressor genes have been implicated in the progression of ovarian cancer. In this review, we highlight the genetic alterations undergone by the key oncogenes and tumor suppressor genes responsible for the development of ovarian cancer. We also summarize the role of these oncogenes and tumor suppressor genes and their association with a deregulated network of fatty acid, glycolysis, tricarboxylic acid and amino acid metabolism in ovarian cancers. Identification of genomic and metabolic circuits will be useful in clinical stratification of patients with complex etiologies and in identifying drug targets for personalized therapies against cancer. |
| first_indexed | 2024-03-11T04:46:14Z |
| format | Article |
| id | doaj.art-fc4af6e332fd4b70ae83324d7f3f785a |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-11T04:46:14Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-fc4af6e332fd4b70ae83324d7f3f785a2023-11-17T20:25:13ZengMDPI AGMetabolites2218-19892023-04-0113456010.3390/metabo13040560Deregulated Metabolic Pathways in Ovarian Cancer: Cause and ConsequenceRoopak Murali0Vaishnavi Balasubramaniam1Satish Srinivas2Sandhya Sundaram3Ganesh Venkatraman4Sudha Warrier5Arun Dharmarajan6Rajesh Kumar Gandhirajan7Department of Human Genetics, Faculty of Biomedical Sciences Technology and Research, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Porur, Chennai 600116, IndiaDepartment of Human Genetics, Faculty of Biomedical Sciences Technology and Research, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Porur, Chennai 600116, IndiaDepartment of Radiation Oncology, Sri Ramachandra Medical College & Research Institute, Sri Ramachandra Institute of Higher Education & Research (Deemed to be University), Porur, Chennai 600116, IndiaDepartment of Pathology, Sri Ramachandra Medical College & Research Institute, Sri Ramachandra Institute of Higher Education & Research (Deemed to be University), Porur, Chennai 600116, IndiaDepartment of Human Genetics, Faculty of Biomedical Sciences Technology and Research, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Porur, Chennai 600116, IndiaDivision of Cancer Stem Cells and Cardiovascular Regeneration, School of Regenerative Medicine, Manipal Academy of Higher Education (MAHE), Bangalore 560065, IndiaDepartment of Biomedical Sciences, Faculty of Biomedical Sciences Technology and Research, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Porur, Chennai 600116, IndiaDepartment of Human Genetics, Faculty of Biomedical Sciences Technology and Research, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Porur, Chennai 600116, IndiaOvarian cancers are tumors that originate from the different cells of the ovary and account for almost 4% of all the cancers in women globally. More than 30 types of tumors have been identified based on the cellular origins. Epithelial ovarian cancer (EOC) is the most common and lethal type of ovarian cancer which can be further divided into high-grade serous, low-grade serous, endometrioid, clear cell, and mucinous carcinoma. Ovarian carcinogenesis has been long attributed to endometriosis which is a chronic inflammation of the reproductive tract leading to progressive accumulation of mutations. Due to the advent of multi-omics datasets, the consequences of somatic mutations and their role in altered tumor metabolism has been well elucidated. Several oncogenes and tumor suppressor genes have been implicated in the progression of ovarian cancer. In this review, we highlight the genetic alterations undergone by the key oncogenes and tumor suppressor genes responsible for the development of ovarian cancer. We also summarize the role of these oncogenes and tumor suppressor genes and their association with a deregulated network of fatty acid, glycolysis, tricarboxylic acid and amino acid metabolism in ovarian cancers. Identification of genomic and metabolic circuits will be useful in clinical stratification of patients with complex etiologies and in identifying drug targets for personalized therapies against cancer.https://www.mdpi.com/2218-1989/13/4/560ovarian cancertumor metabolismoncogenestumor suppressor genes |
| spellingShingle | Roopak Murali Vaishnavi Balasubramaniam Satish Srinivas Sandhya Sundaram Ganesh Venkatraman Sudha Warrier Arun Dharmarajan Rajesh Kumar Gandhirajan Deregulated Metabolic Pathways in Ovarian Cancer: Cause and Consequence Metabolites ovarian cancer tumor metabolism oncogenes tumor suppressor genes |
| title | Deregulated Metabolic Pathways in Ovarian Cancer: Cause and Consequence |
| title_full | Deregulated Metabolic Pathways in Ovarian Cancer: Cause and Consequence |
| title_fullStr | Deregulated Metabolic Pathways in Ovarian Cancer: Cause and Consequence |
| title_full_unstemmed | Deregulated Metabolic Pathways in Ovarian Cancer: Cause and Consequence |
| title_short | Deregulated Metabolic Pathways in Ovarian Cancer: Cause and Consequence |
| title_sort | deregulated metabolic pathways in ovarian cancer cause and consequence |
| topic | ovarian cancer tumor metabolism oncogenes tumor suppressor genes |
| url | https://www.mdpi.com/2218-1989/13/4/560 |
| work_keys_str_mv | AT roopakmurali deregulatedmetabolicpathwaysinovariancancercauseandconsequence AT vaishnavibalasubramaniam deregulatedmetabolicpathwaysinovariancancercauseandconsequence AT satishsrinivas deregulatedmetabolicpathwaysinovariancancercauseandconsequence AT sandhyasundaram deregulatedmetabolicpathwaysinovariancancercauseandconsequence AT ganeshvenkatraman deregulatedmetabolicpathwaysinovariancancercauseandconsequence AT sudhawarrier deregulatedmetabolicpathwaysinovariancancercauseandconsequence AT arundharmarajan deregulatedmetabolicpathwaysinovariancancercauseandconsequence AT rajeshkumargandhirajan deregulatedmetabolicpathwaysinovariancancercauseandconsequence |