Changes in plasma alpha‐1 acid glycoprotein following hemorrhagic trauma: Possible role in dose differences of ALM drug therapy in rat and pig resuscitation

Changes in plasma alpha‐1 acid glycoprotein following hemorrhagic trauma: Possible role in dose differences of ALM drug therapy in rat and pig resuscitation

Abstract Introduction The binding of drugs to plasma proteins is an important consideration in drug development. We have reported that the dose of adenosine, lidocaine, and magnesium (ALM) fluid therapy for resuscitation from hemorrhagic shock is nearly 3‐times higher for pigs than rats. Since lidoc...

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Bibliographic Details
Main Authors: Hayley L. Letson, Jodie L. Morris, Geoffrey P. Dobson
Format: Article
Language:English
Published: Wiley 2023-10-01
Series:Pharmacology Research & Perspectives
Subjects:
ALM
alpha‐1 acid glycoprotein
dosage
hemorrhage
serum proteins
trauma
Online Access:https://doi.org/10.1002/prp2.1133

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