Pulmonary dust foci as rat pneumoconiosis lesion induced by titanium dioxide nanoparticles in 13-week inhalation study

Pulmonary dust foci as rat pneumoconiosis lesion induced by titanium dioxide nanoparticles in 13-week inhalation study

Abstract Background Most toxicological studies on titanium dioxide (TiO2) particles to date have concentrated on carcinogenicity and acute toxicity, with few studies focusing of pneumoconiosis, which is a variety of airspace and interstitial lung diseases caused by particle-laden macrophages. The pr...

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Bibliographic Details
Main Authors: Shotaro Yamano, Yuko Goto, Tomoki Takeda, Shigeyuki Hirai, Yusuke Furukawa, Yoshinori Kikuchi, Tatsuya Kasai, Kyohei Misumi, Masaaki Suzuki, Kenji Takanobu, Hideki Senoh, Misae Saito, Hitomi Kondo, Yumi Umeda
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Particle and Fibre Toxicology
Subjects:
Titanium dioxide nanoparticles (TiO2 NPs)
Rat pneumoconiosis
Pulmonary dust foci (PDF)
F344 rat
Whole-body inhalation
Online Access:https://doi.org/10.1186/s12989-022-00498-3

Internet

https://doi.org/10.1186/s12989-022-00498-3

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