Effects of different n-6/n-3 polyunsaturated fatty acids ratios on lipid metabolism in patients with hyperlipidemia: a randomized controlled clinical trial
Background and aimsIntake of n-3 polyunsaturated fatty acids (PUFA) is helpful for cardiometabolic health. It improves lipid metabolism, and increasing n-3 PUFA is often considered beneficial. However, the role of n-6/n-3 in the regulation of lipid metabolism has been much debated. Therefore, this s...
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1166702/full |
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| author | Yiwei Yang Yiwei Yang Yiwei Yang Yanping Xia Yanping Xia Yanping Xia Baixi Zhang Dan Li Dan Li Dan Li Jiai Yan Jiai Yan Jiai Yan Ju Yang Ju Yang Ju Yang Jing Sun Jing Sun Jing Sun Hong Cao Hong Cao Hong Cao Yingyu Wang Yingyu Wang Yingyu Wang Feng Zhang Feng Zhang Feng Zhang Feng Zhang |
| author_facet | Yiwei Yang Yiwei Yang Yiwei Yang Yanping Xia Yanping Xia Yanping Xia Baixi Zhang Dan Li Dan Li Dan Li Jiai Yan Jiai Yan Jiai Yan Ju Yang Ju Yang Ju Yang Jing Sun Jing Sun Jing Sun Hong Cao Hong Cao Hong Cao Yingyu Wang Yingyu Wang Yingyu Wang Feng Zhang Feng Zhang Feng Zhang Feng Zhang |
| author_sort | Yiwei Yang |
| collection | DOAJ |
| description | Background and aimsIntake of n-3 polyunsaturated fatty acids (PUFA) is helpful for cardiometabolic health. It improves lipid metabolism, and increasing n-3 PUFA is often considered beneficial. However, the role of n-6/n-3 in the regulation of lipid metabolism has been much debated. Therefore, this study was performed on the effect of different proportions of n-6/n-3 diet on lipid metabolism, and quality of life in patients with hyperlipidemia, aiming to explore appropriate proportions of n-6/n-3 to provide the theoretical basis for the development and application of nutritional blended oil in the future.MethodsThese 75 participants were randomized and assigned into three groups, which received dietary oil with high n-6/n-3 PUFA ratios (HP group: n-6/n-3 = 7.5/1), dietary oil with middle n-6/n-3 PUFA ratios (MP group: n-6/n-3 = 2.5/1) or low n-6/n-3 PUFA ratios (LP group: n-6/n-3 = 1/2.5). All patients received dietary guidance and health education were monitored for hyperlipidemia. Anthropometric, lipid and blood glucose parameters and quality of life were assessed at baseline and 60 days after intervention.ResultAfter 60 days, high-density lipoprotein cholesterol (HDL-c) level was increased (p = 0.029) and Total cholesterol (TC) level was decreased (p = 0.003) in the MP group. In the LP group, TC level was decreased (p = 0.001), TG level was decreased (p = 0.001), but HDL-c level was not significantly increased. At the end of intervention, quality of life’ score was improved in both MP and LP groups (p = 0.037).ConclusionDecreasing the intake of edible oil n-6/n-3 ratio can improve blood lipids and quality of life. This is significant for the prevention of cardiovascular disease (CVD). It is also essential to note that an excessive reduction of the n-6/n-3 ratio does not further improve the blood lipid metabolism. In addition, the application of perilla oil in nutritional blended oil has particular significance.Clinical trial registrationhttps://www.chictr.org.cn/indexEN.html, identifier ChiCTR-2300068198. |
| first_indexed | 2024-03-13T08:05:49Z |
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| last_indexed | 2024-03-13T08:05:49Z |
| publishDate | 2023-06-01 |
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| spelling | doaj.art-fc4de667e0e44704ae6c051f28e6ce062023-06-01T05:26:50ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-06-011010.3389/fnut.2023.11667021166702Effects of different n-6/n-3 polyunsaturated fatty acids ratios on lipid metabolism in patients with hyperlipidemia: a randomized controlled clinical trialYiwei Yang0Yiwei Yang1Yiwei Yang2Yanping Xia3Yanping Xia4Yanping Xia5Baixi Zhang6Dan Li7Dan Li8Dan Li9Jiai Yan10Jiai Yan11Jiai Yan12Ju Yang13Ju Yang14Ju Yang15Jing Sun16Jing Sun17Jing Sun18Hong Cao19Hong Cao20Hong Cao21Yingyu Wang22Yingyu Wang23Yingyu Wang24Feng Zhang25Feng Zhang26Feng Zhang27Feng Zhang28Wuxi School of Medicine, Jiangnan University, Wuxi, ChinaDepartment of Nutrition, Affiliated Hospital of Jiangnan University, Wuxi, ChinaClinical Evaluation Center for Functional Food, Affiliated Hospital of Jiangnan University, Wuxi, ChinaDepartment of Nutrition, Affiliated Hospital of Jiangnan University, Wuxi, ChinaClinical Evaluation Center for Functional Food, Affiliated Hospital of Jiangnan University, Wuxi, ChinaYixing Institute of Food and Biotechnology Co., Ltd., Yixing, ChinaSchool of Food Science and Technology, Jiangnan University, Wuxi, ChinaDepartment of Nutrition, Affiliated Hospital of Jiangnan University, Wuxi, ChinaClinical Evaluation Center for Functional Food, Affiliated Hospital of Jiangnan University, Wuxi, ChinaYixing Institute of Food and Biotechnology Co., Ltd., Yixing, ChinaDepartment of Nutrition, Affiliated Hospital of Jiangnan University, Wuxi, ChinaClinical Evaluation Center for Functional Food, Affiliated Hospital of Jiangnan University, Wuxi, ChinaYixing Institute of Food and Biotechnology Co., Ltd., Yixing, ChinaDepartment of Nutrition, Affiliated Hospital of Jiangnan University, Wuxi, ChinaClinical Evaluation Center for Functional Food, Affiliated Hospital of Jiangnan University, Wuxi, ChinaYixing Institute of Food and Biotechnology Co., Ltd., Yixing, ChinaDepartment of Nutrition, Affiliated Hospital of Jiangnan University, Wuxi, ChinaClinical Evaluation Center for Functional Food, Affiliated Hospital of Jiangnan University, Wuxi, ChinaYixing Institute of Food and Biotechnology Co., Ltd., Yixing, ChinaDepartment of Nutrition, Affiliated Hospital of Jiangnan University, Wuxi, ChinaClinical Evaluation Center for Functional Food, Affiliated Hospital of Jiangnan University, Wuxi, ChinaYixing Institute of Food and Biotechnology Co., Ltd., Yixing, ChinaDepartment of Nutrition, Affiliated Hospital of Jiangnan University, Wuxi, ChinaClinical Evaluation Center for Functional Food, Affiliated Hospital of Jiangnan University, Wuxi, ChinaYixing Institute of Food and Biotechnology Co., Ltd., Yixing, ChinaWuxi School of Medicine, Jiangnan University, Wuxi, ChinaDepartment of Nutrition, Affiliated Hospital of Jiangnan University, Wuxi, ChinaClinical Evaluation Center for Functional Food, Affiliated Hospital of Jiangnan University, Wuxi, ChinaYixing Institute of Food and Biotechnology Co., Ltd., Yixing, ChinaBackground and aimsIntake of n-3 polyunsaturated fatty acids (PUFA) is helpful for cardiometabolic health. It improves lipid metabolism, and increasing n-3 PUFA is often considered beneficial. However, the role of n-6/n-3 in the regulation of lipid metabolism has been much debated. Therefore, this study was performed on the effect of different proportions of n-6/n-3 diet on lipid metabolism, and quality of life in patients with hyperlipidemia, aiming to explore appropriate proportions of n-6/n-3 to provide the theoretical basis for the development and application of nutritional blended oil in the future.MethodsThese 75 participants were randomized and assigned into three groups, which received dietary oil with high n-6/n-3 PUFA ratios (HP group: n-6/n-3 = 7.5/1), dietary oil with middle n-6/n-3 PUFA ratios (MP group: n-6/n-3 = 2.5/1) or low n-6/n-3 PUFA ratios (LP group: n-6/n-3 = 1/2.5). All patients received dietary guidance and health education were monitored for hyperlipidemia. Anthropometric, lipid and blood glucose parameters and quality of life were assessed at baseline and 60 days after intervention.ResultAfter 60 days, high-density lipoprotein cholesterol (HDL-c) level was increased (p = 0.029) and Total cholesterol (TC) level was decreased (p = 0.003) in the MP group. In the LP group, TC level was decreased (p = 0.001), TG level was decreased (p = 0.001), but HDL-c level was not significantly increased. At the end of intervention, quality of life’ score was improved in both MP and LP groups (p = 0.037).ConclusionDecreasing the intake of edible oil n-6/n-3 ratio can improve blood lipids and quality of life. This is significant for the prevention of cardiovascular disease (CVD). It is also essential to note that an excessive reduction of the n-6/n-3 ratio does not further improve the blood lipid metabolism. In addition, the application of perilla oil in nutritional blended oil has particular significance.Clinical trial registrationhttps://www.chictr.org.cn/indexEN.html, identifier ChiCTR-2300068198.https://www.frontiersin.org/articles/10.3389/fnut.2023.1166702/fulln-6/ n-3 polyunsaturated fatty acids ratiocardiometabolic healthhyperlipidemialipid metabolismperilla oil |
| spellingShingle | Yiwei Yang Yiwei Yang Yiwei Yang Yanping Xia Yanping Xia Yanping Xia Baixi Zhang Dan Li Dan Li Dan Li Jiai Yan Jiai Yan Jiai Yan Ju Yang Ju Yang Ju Yang Jing Sun Jing Sun Jing Sun Hong Cao Hong Cao Hong Cao Yingyu Wang Yingyu Wang Yingyu Wang Feng Zhang Feng Zhang Feng Zhang Feng Zhang Effects of different n-6/n-3 polyunsaturated fatty acids ratios on lipid metabolism in patients with hyperlipidemia: a randomized controlled clinical trial Frontiers in Nutrition n-6/ n-3 polyunsaturated fatty acids ratio cardiometabolic health hyperlipidemia lipid metabolism perilla oil |
| title | Effects of different n-6/n-3 polyunsaturated fatty acids ratios on lipid metabolism in patients with hyperlipidemia: a randomized controlled clinical trial |
| title_full | Effects of different n-6/n-3 polyunsaturated fatty acids ratios on lipid metabolism in patients with hyperlipidemia: a randomized controlled clinical trial |
| title_fullStr | Effects of different n-6/n-3 polyunsaturated fatty acids ratios on lipid metabolism in patients with hyperlipidemia: a randomized controlled clinical trial |
| title_full_unstemmed | Effects of different n-6/n-3 polyunsaturated fatty acids ratios on lipid metabolism in patients with hyperlipidemia: a randomized controlled clinical trial |
| title_short | Effects of different n-6/n-3 polyunsaturated fatty acids ratios on lipid metabolism in patients with hyperlipidemia: a randomized controlled clinical trial |
| title_sort | effects of different n 6 n 3 polyunsaturated fatty acids ratios on lipid metabolism in patients with hyperlipidemia a randomized controlled clinical trial |
| topic | n-6/ n-3 polyunsaturated fatty acids ratio cardiometabolic health hyperlipidemia lipid metabolism perilla oil |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1166702/full |
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