Intrahepatic cholangiocarcinoma: histological diversity and the role of the pathologist
Intrahepatic cholangiocarcinoma (iCCA) is one of the primary liver cancers and presents with tumor heterogeneity. About 50% of iCCAs comprise actionable mutations, which completely change patient management. In addition, the precise diagnosis of iCCA, including subtype, has become crucial, and patho...
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| Format: | Article |
| Language: | English |
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Korean Liver Cancer Association
2024-03-01
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| Series: | Journal of Liver Cancer |
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| Online Access: | http://www.e-jlc.org/upload/pdf/jlc-2023-12-11.pdf |
| _version_ | 1797224510138613760 |
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| author | Mina Komuta |
| author_facet | Mina Komuta |
| author_sort | Mina Komuta |
| collection | DOAJ |
| description | Intrahepatic cholangiocarcinoma (iCCA) is one of the primary liver cancers and presents with tumor heterogeneity. About 50% of iCCAs comprise actionable mutations, which completely change patient management. In addition, the precise diagnosis of iCCA, including subtype, has become crucial, and pathologists play an important role in this regard. This review focuses on iCCA heterogeneity; looking at different perspectives to guide diagnosis and optimal treatment choice. |
| first_indexed | 2024-04-24T13:54:16Z |
| format | Article |
| id | doaj.art-fc4e9b5b867a464ea33a84d3cea26793 |
| institution | Directory Open Access Journal |
| issn | 2288-8128 2383-5001 |
| language | English |
| last_indexed | 2024-04-24T13:54:16Z |
| publishDate | 2024-03-01 |
| publisher | Korean Liver Cancer Association |
| record_format | Article |
| series | Journal of Liver Cancer |
| spelling | doaj.art-fc4e9b5b867a464ea33a84d3cea267932024-04-04T00:04:50ZengKorean Liver Cancer AssociationJournal of Liver Cancer2288-81282383-50012024-03-01241172210.17998/jlc.2023.12.11549Intrahepatic cholangiocarcinoma: histological diversity and the role of the pathologistMina Komuta0 Department of Pathology, International University of Health and Welfare School of Medicine, IUHW Narita Hospital, Chiba, JapanIntrahepatic cholangiocarcinoma (iCCA) is one of the primary liver cancers and presents with tumor heterogeneity. About 50% of iCCAs comprise actionable mutations, which completely change patient management. In addition, the precise diagnosis of iCCA, including subtype, has become crucial, and pathologists play an important role in this regard. This review focuses on iCCA heterogeneity; looking at different perspectives to guide diagnosis and optimal treatment choice.http://www.e-jlc.org/upload/pdf/jlc-2023-12-11.pdfgenetic heterogeneityliver neoplasmsfibroblast growth factor receptors 2pathology, surgicaldiagnosis, differential |
| spellingShingle | Mina Komuta Intrahepatic cholangiocarcinoma: histological diversity and the role of the pathologist Journal of Liver Cancer genetic heterogeneity liver neoplasms fibroblast growth factor receptors 2 pathology, surgical diagnosis, differential |
| title | Intrahepatic cholangiocarcinoma: histological diversity and the role of the pathologist |
| title_full | Intrahepatic cholangiocarcinoma: histological diversity and the role of the pathologist |
| title_fullStr | Intrahepatic cholangiocarcinoma: histological diversity and the role of the pathologist |
| title_full_unstemmed | Intrahepatic cholangiocarcinoma: histological diversity and the role of the pathologist |
| title_short | Intrahepatic cholangiocarcinoma: histological diversity and the role of the pathologist |
| title_sort | intrahepatic cholangiocarcinoma histological diversity and the role of the pathologist |
| topic | genetic heterogeneity liver neoplasms fibroblast growth factor receptors 2 pathology, surgical diagnosis, differential |
| url | http://www.e-jlc.org/upload/pdf/jlc-2023-12-11.pdf |
| work_keys_str_mv | AT minakomuta intrahepaticcholangiocarcinomahistologicaldiversityandtheroleofthepathologist |